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Preparation method of smellless coated enrofloxacin preparation

A technology of enrofloxacin and preparations, which is applied in the field of preparation of odorless coated enrofloxacin preparations, can solve problems such as easy moisture absorption and agglomeration, reduced drug efficacy, and troublesome production and processing, so as to avoid stomach cramps in feeding animals , reduce the loss of drug efficacy, and avoid the effect of photodecomposition

Active Publication Date: 2013-08-14
ZHEJIANG KING TECHINA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, enrofloxacin has a bitter taste. For pigs with a highly developed taste system, direct feeding can easily lead to food refusal and decreased feed intake. In addition, it has a strong chemical stimulation effect on the stomach, which can easily cause stomach cramps and lead to animal Vomiting and other phenomena occur. The above reasons make it difficult to directly administer enrofloxacin orally. Therefore, pigs are usually given intramuscular injection of enrofloxacin injection, but the workload of injection is heavy and the stress on pigs is also greater.
In addition, enrofloxacin is easy to decompose when exposed to light, and it is easy to absorb moisture and agglomerate, which leads to a decrease in its efficacy and also brings troubles to production and processing.
Although there is research on enrofloxacin microcapsules, its production and application cannot be mixed with wet materials, which greatly limits its wide application

Method used

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  • Preparation method of smellless coated enrofloxacin preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] (1) Weigh each raw material:

[0012] Enrofloxacin 8kg

[0013] Polyacrylic resin type II 0.05kg

[0014] Polyethylene glycol 1.95kg

[0015] Stearic acid 60kg

[0016] β-cyclodextrin 30kg

[0017] 55kg of water

[0018] Anhydrous ethanol 40kg

[0019] (2) Preparation method: In the first step, mix β-cyclodextrin and water, and stir into a uniform state, add enrofloxacin and polyethylene glycol, and stir the mixture in a ball mill for 12 hours to fully include , that is, to obtain enrofloxacin inclusion compound; the second step is to dry the completed inclusion compound at 65°C, crush it, and pass it through an 80-mesh analytical sieve; the third step is to put stearic acid into the reaction kettle , heated to a transparent liquid state, put in the crushed enrofloxacin inclusion compound, stir and mix, spray, and freeze-dry to obtain microcapsule particles of about 20 mesh; the fourth step is to dissolve the hydrophobic Material (polyacrylic acid resin type II),...

Embodiment 2

[0021] (1) Weigh each raw material:

[0022] Enrofloxacin 15kg

[0023] Polyacrylic resin type II 0.1kg

[0024] Polyethylene glycol 4.9kg

[0025] Stearic acid 50kg

[0026] β-cyclodextrin 30kg

[0027] 50kg of water

[0028] Anhydrous ethanol 40kg

[0029] (2) Preparation method: In the first step, mix β-cyclodextrin and water, and stir into a uniform state, add enrofloxacin and polyethylene glycol, and stir the mixture in a ball mill for 12 hours to fully include , that is, to obtain enrofloxacin inclusion compound; the second step is to dry the completed inclusion compound at 65°C, crush it, and pass it through an 80-mesh analytical sieve; the third step is to put stearic acid into the reaction kettle , heated to a transparent liquid state, put in the crushed enrofloxacin inclusion compound, stir and mix, spray, and freeze-dry to obtain microcapsule particles of about 20 mesh; the fourth step is to dissolve the hydrophobic Material (polyacrylic acid resin type II), ...

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Abstract

The invention relates to an antibacterial drug for livestock, particularly a preparation method of a smellless coated enrofloxacin preparation. The antibacterial drug for livestock is prepared from the following raw materials in percentage by weight: 5-15% of enrofloxacin, 0.01-0.1% of polyacrylic resin II, 1-10% of polyethyleneglycol, 50-70% of stearic acid, 25-45% of beta-cyclodextrin, 50-60% of water and 30-50% of anhydrous ethanol. The preparation method comprises the following steps: evenly stirring beta-cyclodextrin and water, adding enrofloxacin and polyethyleneglycol, stirring, drying the obtained inclusion compound, and pulverizing; heating stearic acid to a transparent liquid, adding the pulverized inclusion compound, and carrying out spray freeze-drying to obtain microcapsule particles; and finally, dissolving a hydrophobic material in anhydrous ethanol, and carrying out bottom-spray coating on the microcapsule particles to obtain the finished product. After the enrofloxacin is coated, the bitterness is covered up, so that the enrofloxacin does not stimulate the stomach, thereby preventing the ingesting animals from gastrospasm and nausea, and thus, the enrofloxacin can be orally dosed to pigs; the multilayer coating prevents the enrofloxacin from composition under the light, and can be mixed in a wet state; and the invention is convenient for production, and fully displays the powerful bactericidal action of enrofloxacin.

Description

1. Technical field [0001] The invention relates to a veterinary antibacterial drug, in particular to a preparation method of an odorless coated enrofloxacin preparation. 2. Background technology [0002] Enrofloxacin (Enrofloxacin) is a third-generation quinolone antibacterial drug, also known as ethyl ciprofloxacin, ethyl ciprofloxacin, enrofloxacin, etc. It was first developed by Bayer in Germany in the 1980s Successfully developed in my country in 1993, enrofloxacin is currently designated as a special drug for animals by the state. [0003] The molecular formula of enrofloxacin is C 19 h 22 FN 3 o 3 , molecular weight 359.40, its appearance is slightly yellow or light orange crystalline powder; odorless, bitter taste; the color gradually turns orange red when exposed to light. Soluble in chloroform, slightly soluble in water, easy to absorb moisture and agglomerate in the air. [0004] Enrofloxacin has a wide antibacterial spectrum and strong bactericidal activity. ...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K9/50A61P31/04
Inventor 李浙烽余荣陈强徐二华徐小芳王雯熙
Owner ZHEJIANG KING TECHINA TECH
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