202 results about "Montelukast Sodium" patented technology

The invention belongs to the field of medicine preparations, which particularly relates to a chewable tablet of montelukast sodium. Because the production process of the chewable tablet of the montelukast sodium needs the light shielding operation at present, the mass production is inconvenient, and the chewable tablet of the montelukast sodium has the defect of poorer stability. In the invention, zinc stearate and an opacifier of iron oxide red, iron oxide yellow and titanium dioxide are added into the auxiliary materials of a chewable tablet of montelukast, so that the content of relevant substances can be lowered, and the stability of the chewable tablet is enhanced.

The invention provides a montelukast sodium liposome solid preparation which is prepared from raw and auxiliary materials comprising the following components in parts by weight: 5 parts of montelukast sodium, 15-30 parts of hydrogenated soybean phosphatidylcholine (HSPC), 8-20 parts of cholesterol, 4-12 parts of Tween 80, 20-50 parts of mannitol and 1-3 parts of soyasterol. The montelukast sodiumliposome solid preparation has high stability, is stable in light and heat environments, is convenient to store, has the advantages of simple preparation method, high encapsulation rate and uniform particle size and can be preserved in a body for a long time, thereby improving the product quality of the preparation and reducing the toxic side effects.

The invention belongs to the technical field of medicines and particularly relates to a montelukast sodium chewable tablet and a preparation method thereof. The montelukast sodium chewable tablet provided by the invention is composed of montelukast sodium, a diluting agent, a lubricating agent, a binding agent, a disintegrating agent, a coloring agent, a sweetening agent and a corrigent. A preparation process of the montelukast sodium chewable tablet adopts absolute ethyl alcohol as a solvent to prepare the binding agent and then the binding agent is mixed with powder of other raw materials and auxiliary materials to carry out wet-method granulation. After being dried, wet grains are mixed with the corrigent and the lubricating agent and then a mixture is tabletted. According to the montelukast sodium chewable tablet prepared by using the process method provided by the invention, the color and the luster of the appearance of the tablet are uniform and bright, the stability is good, the disintegrating speed is high and the bioavailability is high.