107 results about "Fat-Soluble Vitamin" patented technology

The invention provides a preparation method and application of a mineral oral liquid containing fat-soluble vitamins, the fat-soluble vitamins are dissolved in an oil phase, then the oil phase is mixed with a water phase containing an emulsifier, and high-shear and high-pressure homogenization treatment is performed to obtain emulsified fat-soluble vitamins; dispersing the sweetening agent, the suspending aid, the pH regulator and the insoluble mineral substances to obtain a mixed solution; adding the emulsified fat-soluble vitamins and the flavor regulator into the mixed solution, adding water to a constant volume, and uniformly stirring to obtain a material solution; and canning the feed liquid, sealing, and sterilizing at high temperature to obtain the oral liquid. The fat-soluble vitamins in the oral liquid provided by the invention are small in particle size after being subjected to high-shear and high-pressure homogenization treatment, can tolerate high-temperature sterilization, is small in loss rate, good in dispersity and high in stability within the shelf life, and can maintain the actual content of the fat-soluble vitamins in the oral liquid and ensure the nutritional effect of the fat-soluble vitamins.

The invention provides application of pediococcus pentosaceus in preparation of a product for improving pork quality and intestinal flora, and relates to the technical field of animal feeding. The pediococcus pentosaceus disclosed by the invention is pediococcus pentosaceus LL2018368, is separated from the digestive tract of a Diqing Tibetan pig and is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.18709. The pediococcus pentosaceus disclosed by the invention has the advantages that the pediococcus pentosaceus can be used for preparing the pediococcus pentosaceus; the pediococcus pentosaceus LL2018368 is added into drinking water of the Du-Si pigs, the influence of the pediococcus pentosaceus LL2018368 on archaea, meat quality, tissue fat-soluble vitamins and excrement metabolite composition in the excrement of the Du-Si pigs is studied, and the result shows that the pediococcus pentosaceus LL2018368 enables the species of the archaea in the excrement to tend to be consistent, so that the content of the archaea in the excrement of the Du-Si pigs in the excrement of the Du-Si pigs in the excrement of the Du-Si pigs is increased. The contents of vitamin A and all-trans-retinol in kidney tissues are increased, and the probiotic functions of amino acid and fat metabolism related bacteria and enzymes are improved.

The invention discloses a preservation reagent, a preservation method and a detection method for fat-soluble vitamins D2, D3, A and E in peripheral blood. The preservation reagent comprises the following components: 1-15% of a PBS (Phosphate Buffer Solution) (v / v), 80-95% of a sodium chloride solution (v / v), 0.5-2.5% of Tris-HCl (v / v) and 0.5-2.5% of a stabilizer (w / v). According to the preservation reagent and the preservation method, fat-soluble vitamins D2, D3, A and E in the human whole blood sample can be stably preserved for 28 days at the temperature of 2-8 DEG C under the dark condition, preservation and transportation of the human whole blood sample are facilitated, and detection of the fat-soluble vitamins is facilitated. The precision and accuracy of detection can be improved, and interference of triglyceride, bilirubin and the like on detection of fat-soluble vitamins can be avoided.

The invention relates to the technical field of functional food preparation, in particular to an instant sugar-free vitamin mineral composition and a preparation method thereof. The composition comprises vitamin microcapsule powder, vitamin mineral particles, maltodextrin and a food additive. The composition is prepared by a three-step method comprising the following steps: firstly, preparing fat-soluble vitamin, natural colloid, protein and the like into microcapsules; carrying out superfine grinding on water-soluble vitamins and mineral substances, granulating with maltodextrin and the like, and controlling the particle size of particles; and finally, mixing the components in proportion. Sugar-free wall materials such as natural vegetable gum, protein and fibers are adopted, traditional saccharides are not used, and the sugar-free wall materials have good instant solubility, dispersity and stability, can effectively cover bitter taste and metal taste of vitamins and mineral substances, are suitable for different people, especially people needing sugar control, and achieve comprehensive, stable and easy-to-absorb nutritional supplement.

The invention discloses a method for detecting the content of fat-soluble vitamins A, D and E in blood. The method comprises the following steps: adding 250 mu L of BHT (butylated hydroxytoluene) internal standard solution into every 50 mu L of a blood sample; adding 20 [mu] L of a zinc sulfate heptahydrate solution into the blood sample added with the BHT internal standard solution, and sequentially carrying out primary uniform mixing and centrifugal treatment; taking 100 microliters of centrifuged supernate, and concentrating and drying; adding 50 [mu] L of a PTAD (4-phenyl-1, 2, 4-triazoline-3, 5-diketone) acetonitrile solution into the concentrated and dried supernatant at normal temperature, carrying out a derivatization reaction, and then adding a quenching agent to terminate the derivatization reaction so as to obtain a derivative sample; and adding 100 microliters of centrifuged supernate into the derivative sample, uniformly mixing again, and detecting. Through screening of the quenching agent, the response of the vitamins can be obviously enhanced, and the detection of the contents of the fat-soluble vitamins A, D and E can be rapidly and accurately completed.

The invention relates to the technical field of analytical chemistry, in particular to a method for simultaneously determining seven fat-soluble vitamin compounds. The method comprises the following steps: in 0-4.5 minutes, transferring a sample solution into an on-line solid-phase extraction column by a sample loading pump, and communicating an analysis pump with a liquid chromatographic analysis column through a switching valve for balancing; in 4.5-6.5 min, adjusting the state of a switching valve, respectively communicating two ends of the online solid-phase extraction column with an analysis column and an analysis pump of the liquid chromatography, and backflushing the analyte from the online solid-phase extraction column and transferring the analyte into the analysis column of the liquid chromatography by a mobile phase of the analysis pump; and 6.5-42 min, adjusting the state of the switching valve, flushing and balancing the on-line solid phase extraction column by the sample loading pump, and completing separation and analysis of the analyte by matching the analysis pump with the analysis column of the liquid chromatography. According to the method disclosed by the invention, saponification liquid can be directly analyzed on a machine, and seven target compounds can be separated and detected within 42 minutes.

The invention discloses double-embedded microcapsule powder as well as a formula, a preparation method and application thereof, and belongs to the technical field of foods. According to the invention, phase condensation is carried out on core materials with different polarities, so that microcapsule powder capable of pairwise embedding the core materials with different polarities, lipophilic core materials such as vegetable oil (conjugated linoleic acid glyceride, medium chain triglyceride, DHA algal oil, linseed oil, sunflower seed oil and the like), animal oil, haematococcus pluvialis oil or fat-soluble vitamins and the like are obtained; the hydrophilic core materials comprise water-soluble vitamins, high-solubility amino acids and the like, the amphiphilic core materials comprise diglyceride oil, phospholipid oil, sugar fat oil and the like, and the amphoteric insoluble core materials comprise polyphenol substances or low-solubility amino acid substances and the like. According to the microcapsule powder and the preparation method thereof, diversification and compatibility of properties of the core material are realized, the corresponding microcapsule powder effectively isolates negative effects of external environmental factors such as oxygen, moisture, illumination and temperature change on the core material, and the microcapsule powder can be widely applied to industries such as medicine, food and cosmetics.

The invention discloses a fat-soluble vitamin embedding material which comprises a medicine core and a zwitterionic membrane coating the medicine core, the medicine core is an oil-phase substance in which fat-soluble vitamins are dissolved; the zwitterionic membrane is obtained by crosslinking chitosan and sodium alginate. The invention also discloses a preparation method of the fat-soluble vitamin embedding material. The preparation method comprises the following steps: dissolving the fat-soluble vitamin in an oil phase substance to obtain an oil phase; and taking the oil phase, a sodium alginate aqueous solution and an acetic acid aqueous solution of chitosan to form W / O / W multiple emulsion, so that sodium alginate and chitosan are crosslinked, and then performing spray drying to obtain the fat-soluble vitamin embedding material. The invention also discloses an application of the fat-soluble vitamin embedding material in preparation of a calcium carbonate preparation. The invention also discloses a composite calcium carbonate / vitamin D3 preparation which comprises the following raw materials: calcium carbonate and the fat-soluble vitamin embedding material, and the fat-soluble vitamin is vitamin D3. The embedded substance is stable in quality and can be uniformly mixed with calcium carbonate.

The invention discloses a 96-hole preassembled plate fat-soluble vitamin pretreatment kit, and belongs to the technical field of in-vitro diagnostic reagents. Comprising magnetic bead suspension liquid, equilibrium liquid, leacheate 1, leacheate 2 and eluent which are carried on a preassembled plate, and the magnetic bead suspension liquid comprises absolute ethyl alcohol and magnetic beads; the preparation process of the magnetic beads comprises the following steps: activating carboxyl of the carboxyl magnetic beads through EDC and NHS; then nitrochlorobenzene and triethylamine are added for a coupling reaction; mixing the coupling reaction product with pyrrolidone, ammonium persulfate and a pore-foaming agent to obtain target magnetic beads; the magnetic beads can be specifically combined with fat-soluble vitamins in human serum or plasma, efficient separation and release of an object to be detected are achieved through a magnetic separation technology, and the magnetic beads are suitable for follow-up mass spectrum quantitative analysis. The kit disclosed by the invention has the characteristics of simplicity and convenience in operation, high extraction efficiency and good stability, the pretreatment time can be remarkably shortened, the detection accuracy is improved, and an efficient solution is provided for clinical detection of fat-soluble vitamins.

The invention relates to the field of detection, in particular to a method for simultaneously detecting multiple fat-soluble vitamins, which comprises the following steps: (S.1) carrying out protein precipitation and liquid-liquid extraction on a sample to be detected to obtain an extract containing fat-soluble vitamins; (S.2) carrying out derivatization reaction on the extract by using a PTAD derivatization reagent; and (S.3) analyzing the derivatized product by adopting a liquid chromatography-tandem mass spectrometry method, wherein the detected target fat-soluble vitamins comprise vitamin A, vitamin E, 25-hydroxy vitamin D2, 25-hydroxy vitamin D3, vitamin K1, vitamin K2 and vitamin K2. According to the application, PTAD is creatively adopted as a unified derivatization reagent, simultaneous and efficient derivatization of seven fat-soluble vitamins is successfully realized, the detection sensitivity of low-content targets, especially vitamin D, K2 and the like, is greatly improved, and the core problems of weak signal response and difficulty in accurate quantification are solved.

The present invention provides a vitamin premix and a preparation process thereof, and belongs to the technical field of food additives, the preparation process is as follows: fat-soluble vitamin mixed particles, mixed water-soluble vitamins and mixed minerals are added into a mixer for mixing, then vitamin C, magnesium taurate, amino acids and tricalcium phosphate are added for continuous mixing, and sieving is performed to obtain the vitamin premix. Wherein the fat-soluble vitamin mixed particles comprise the following raw materials: vitamin A, vitamin E acetate, vitamin D3, vitamin K2, Arabic gum, modified protein and beta-cyclodextrin; the mixed water-soluble vitamins comprise the following raw materials: vitamin B1, vitamin B2, vitamin B5, vitamin B12, folic acid and nicotinamide; the mixed mineral substance comprises the following raw materials: ferrous glycinate, calcium citrate, magnesium citrate and zinc glycinate. The vitamin premix prepared by the invention can be used as a nutritional supplement in various foods, is convenient to use, and has good stability and mixing uniformity.

To provide a composition in which a fat-soluble vitamin or its derivative, broadly used in pharmaceuticals, quasi-drugs, or cosmetics, is solubilized.SOLUTION: Provided is a composition comprising a fat-soluble vitamin or its derivative and a temperature-responsive ionic liquid.SELECTED DRAWING: None

To provide a food and drink composition capable of improving a condition of spots appearing on the skin.SOLUTION: A food and drink composition includes: a fat soluble vitamin C derivative; a Pterocarpus marsupium extract containing resveratrol; and at least one type selected from a group consisting of a red wine extract containing resveratrol, a Polygonum root extract containing resveratrol and a grape skin extract containing resveratrol.SELECTED DRAWING: None

The present invention discloses a method for simultaneously detecting a plurality of fat-soluble vitamins and steroid hormones, comprising the following steps: adding an internal standard to a serum sample, mixing, and then adding methyl tert-butyl ether for extraction; extracting the components to be tested into an organic solvent, centrifuging, drying the extract with nitrogen, re-dissolving, and then injecting and analyzing the extract on a liquid chromatography-mass spectrometry system. The detection method of the present invention can simultaneously detect the contents of five fat-soluble vitamins and seventeen steroid hormones in serum (plasma), and simultaneously test a total of 22 substances to be tested, which is accurate and can be quantitatively detected. The present invention adopts a scheme that changes the conventional prior art of using the isotope of the substance to be tested as the internal standard substance, and adopts trenbolone cyclohexylmethyl carbonate as the internal standard, which can simultaneously quantify 22 substances to be tested, greatly reducing the workload.

A composition of matter which promotes vitamin D absorption through a cosmetically acceptable composition formulated using fat soluble vitamin D3 (cholecalciferol) added to a cosmetically acceptable composition that comprises RBD coconut oil.

The invention discloses a method for determining multiple fat-soluble vitamins based on mass spectrometry, which comprises the following steps: S1, pretreating a sample, and centrifuging to take supernate; s2, carrying out solid-phase extraction on the supernate, collecting an eluent, and redissolving; s3, injecting the redissolved solution treated in S2 into a high performance liquid chromatography system for gradient elution; s4, components flowing out of the high performance liquid chromatography system are guided into a tandem mass spectrometer for detection; and S5, acquiring detection data in the step S4, and performing qualitative judgment and quantitative calculation to obtain the content of each fat-soluble vitamin in the sample. Compared with the prior art, the method for determining the multiple fat-soluble vitamins based on the mass spectrometry has the advantages that the efficient and accurate determination of the multiple fat-soluble vitamins in a sample is completed by optimizing sample pretreatment, chromatographic separation and mass spectrometry detection.

The invention provides an extraction solvent composition for simultaneously extracting fat-soluble vitamins and water-soluble vitamins and application of the extraction solvent composition, and belongs to the technical field of vitamin extraction and detection. The extraction solvent composition comprises an acid and a polar aprotic solvent; the acid comprises medium-strong acid or strong acid. The extraction solvent composition comprises the acid and the polar aprotic solvent, so that the extraction solvent composition can extract fat-soluble vitamins and water-soluble vitamins at the same time, the pretreatment process of extraction and detection of vitamins in compound / composite vitamin products is simplified, the time is saved, the method is simple, and the efficiency is high.

The invention relates to a method for preparing a micelle of vitamin or hydrogel. The method comprises a method for preparing lipid-soluble vitamin into the micelle or a method for preparing evening primrose oil into the micelle. The method for preparing the lipid-soluble vitamin into the micelle comprises the following steps: preparing a NaOH solution; weighing purified water in a reaction kettle, adding a sodium hydroxide solution, and stirring until the sodium hydroxide solution is completely dissolved; putting the reaction kettle into a digital display constant-temperature oil bath pan for heat preservation, opening a nitrogen valve, charging nitrogen under the liquid, adding glycocholic acid into the reaction kettle, starting stirring, continuously adding purified water, and stirring; continuously adding a NaOH solution, and continuously stirring; adjusting the pH value; weighing soybean phospholipid, and continuously carrying out heat preservation and stirring; and successively adding vitamin A, vitamin D3 and vitamin E, and continuously carrying out heat preservation and stirring. The vitamin A, the vitamin D and the vitamin E are prepared into micelles and then are uniformly dispersed with other water-soluble vitamins for injection use, so that the vitamin A, the vitamin D and the vitamin E are better supplemented to a human body.

The invention relates to the technical field of detection kits, in particular to a joint detection kit for fat-soluble vitamins A, D, E and K. The joint detection kit comprises a pushing rod, an injector and a detection supporting structure, the upper end of the injector is telescopically connected with the pushing rod, the lower end of the injector is in butt joint communication with the detection supporting structure, and the detection supporting structure is placed at a fixed position. Then the detection liquid is adsorbed through a material pushing rod and an injector, after adsorption is completed, the injector is in butt joint with a detection supporting structure, and then the material pushing rod is pressed, so that the detection liquid reaches the detection supporting structure through the injector; the detection supporting structure is used for detecting fat-soluble vitamins A, D, E and K, the butt-joint detection component rotates through the supporting adjusting component and accelerates drainage work in a centrifugal mode, the butt-joint mechanism is used for limiting an injector, and the first butt-joint disc block, the second butt-joint disc block and the detection mechanism are assembled. Through the arrangement of the structure, the reagent detection work is convenient to carry out.

The invention discloses a special liquid multi-vitamin compound nutrient for livestock and poultry as well as a preparation method and application of the special liquid multi-vitamin compound nutrient. The method comprises the following steps: (1) preparing an oil phase containing fat-soluble vitamins, an emulsifier and fish oil; (2) preparing a water phase containing water-soluble vitamins, amino acids and a traditional Chinese medicine preparation, wherein the traditional Chinese medicine preparation is traditional Chinese medicine preparation modified Sijunzi decoction; (3) adding the water phase into the oil phase for emulsification reaction in batches, wherein the mass ratio of the oil phase to the water phase is 1: (4-6); (4) performing high-pressure homogenization treatment on the emulsion to obtain a nanoscale emulsion, wherein the particle size of the emulsion is less than 30nm; and (5) filtering, sterilizing and packaging. The nano-emulsion is prepared by optimizing the oil-water phase ratio and a fractional emulsification process and combining a high-pressure homogenization technology, the stability and bioavailability of fat-soluble vitamins are remarkably improved, meanwhile, the added traditional Chinese medicine preparation, namely the modified Sijunzi decoction, effectively enhances the immune regulation function of livestock, and the product is good in stabilizing effect and free of toxic and side effects. The method can be widely applied to the livestock breeding field.

This invention discloses a method for preparing fat-soluble vitamin E powder. The specific operation process is as follows: after preparing a powdered drug cocrystal product using ball milling, a more efficient, green, and sustainable mechanochemical method is employed to improve the preparation process, resulting in better uniform dispersion of the drug and carrier. Solubility is used as the evaluation target to screen vitamin E inclusion materials and excipients, and the optimal formulation is selected for preparing the vitamin E cocrystal inclusion complex. Results show that the method of this invention effectively improves the solubility and other physicochemical properties of fat-soluble vitamin E. Its low energy consumption and minimal use of toxic and harmful reagents give it multiple advantages for large-scale production. Therefore, it has broad application potential and is of great significance for the formulation of vitamin drugs.

The invention provides a joint activating and collateral dredging application and a preparation method and application thereof.The joint activating and collateral dredging application is formed by compounding multiple traditional Chinese medicines such as frankincense, myrrh, ligusticum wallichii, radix angelicae pubescentis, lycopodium clavatum and garden balsam stem with a matrix material, nano borneol, microencapsulated menthol and a fat-soluble vitamin E derivative are added as synergistic components; the preparation method comprises the following steps: supercritical CO2 extraction of volatile oil, microwave-assisted water extraction of active components, and high-pressure homogenization and micro-fluidic chip molding technologies are combined to prepare the porous flexible patch. According to the application, medicine absorption is promoted through a nano transdermal technology, a TNF-alpha / IL-1beta inflammation pathway is remarkably inhibited, clinical data shows that the cure rate of the application reaches 35%, the effective rate of the application reaches 75%, and the application can effectively relieve arthralgia and activity limitation caused by rheumatic arthritis, osteoarthritis and the like. The transdermal patch has the characteristics of high transdermal efficiency, lasting effect and convenience in use.

The invention relates to the technical field of enzymatic preparation of grease, in particular to a method for enzymatic preparation of special grease for infant formula milk powder, which comprises the following steps: constructing a pH response type interface biocatalysis system, and synthesizing and enriching functional ester; the preparation method comprises the following steps: preparing an sn-2 palmitic acid diglyceride intermediate based on alcoholysis reaction, and reacting the sn-2 palmitic acid diglyceride intermediate with mixed fatty acid to synthesize the composite structure lipid; and preparing the target mixed grease from the functional ester, the composite structure grease and the fat-soluble vitamin by adopting a low-temperature high-speed shearing and homogenizing technology. According to the method for preparing the grease special for the infant formula milk powder through the enzyme method, pH response type magnetic nano immobilized lipase is prepared, the enzyme activity is controllable, and the grease is recycled and reused through the dual mechanisms of magnetic separation and pH induced aggregation; a fat-soluble vitamin-structural fat-essential fatty acid composite synergistic system is constructed, the functions of energy supply, mineral absorption and micronutrient supplementation are achieved, and a target grease product is purified by adopting a multi-stage molecular distillation step.

The present invention relates to a new delivery system for fat-soluble vitamins.

This invention relates to a pediatric multivitamin injection and its preparation method, specifically to a stable aqueous solution containing fat-soluble and water-soluble vitamins and its preparation process. The main components of this injection consist of two sterile vials. The first vial contains 10 main components. The preparation method for the first vial employs drug inclusion technology, using surfactants to encapsulate the fat-soluble vitamins and disperse them into the water-soluble vitamin solution, followed by pH adjustment, filtration, and filling. The second vial contains 3 main components. The preparation method for the second vial includes: dissolving the main components with excipients and adding them to the system in a fixed order, filtration, and filling. The pediatric multivitamin injection prepared according to the formulation and preparation process of this invention not only significantly improves storage stability and compatibility stability but also reduces the use of stabilizers and excipients, reducing adverse clinical reactions, increasing medication safety, and improving clinical compliance.

The invention belongs to the technical field of food, and particularly relates to recombined soup-stock and a preparation method thereof. The recombined soup-stock is prepared from the following raw materials in parts by weight: 0-1 part of an amino acid mixed preparation, 0-0.5 part of a vitamin preparation, 10-20 parts of animal fat, 0-2 parts of a food additive and the balance of water, wherein the total weight is 100 parts; wherein the amino acid mixed preparation is formed by mixing a water-soluble amino acid aqueous solution and a micro / low water-soluble amino acid grease dispersion liquid according to any proportion, and the vitamin preparation is formed by mixing a water-soluble vitamin aqueous solution and a fat-soluble vitamin grease solution according to any proportion. The food additive comprises an emulsifier, an antioxidant and edible essence. By utilizing the methods, the recombined soup-stock which is unique in flavor, good in taste, easy to industrially produce and very good in practical value is prepared.

The application provides a vitamin premix and a preparation process thereof, and belongs to the technical field of food additives, and the preparation process is as follows: adding mixed microparticles of fat-soluble vitamins, mixed water-soluble vitamins and mixed minerals into a mixer and mixing, then adding vitamin C, magnesium taurate, amino acids and tricalcium phosphate and continuing to mix, and sieving to obtain the vitamin premix. The raw materials of the mixed microparticles of fat-soluble vitamins include vitamin A, vitamin E acetate, vitamin D3, vitamin K2, acacia, modified protein and beta-cyclodextrin; the raw materials of the mixed water-soluble vitamins include vitamin B1, vitamin B2, vitamin B5, vitamin B12, folic acid and nicotinamide; and the raw materials of the mixed minerals include ferrous glycinate, calcium citrate, magnesium citrate and zinc glycinate. The vitamin premix prepared by the application can be used in various foods as a nutritional supplement, is convenient to use, and has good stability and mixing uniformity.

The invention discloses an antioxidant stable multivitamin injection and a preparation process thereof, and relates to the technical field of medicines. The injection comprises a fat-soluble vitamin component, a water-soluble vitamin component, a graded targeting anti-oxidation system, a compound stabilizer and water for injection, the graded targeting anti-oxidation system is matched with an exclusive antioxidant combination according to vitamin solubility difference, and the compound stabilizer synergistically exerts pH stabilization and metal ion chelation effects. The preparation technology comprises the steps of raw material pretreatment, grouped dissolution, mixing and constant volume, low-temperature pulse sterilization and encapsulation, targeted protection of all-component vitamins is achieved through measures of grouped dissolution, whole-process nitrogen protection, precise sterilization parameter control and the like, oxidative degradation and activity loss are reduced, and the quality of the product is improved. The normal-temperature storage stability of the product and the safety and effectiveness of clinical medication are improved.

The invention discloses a preparation method of fat-soluble vitamin E powder. The specific operation process is as follows: after a powdery pharmaceutical co-crystal product is prepared by using a ball milling method, the preparation process is improved by using a more efficient, green and sustainable mechanochemical method, so that the uniform dispersion of a drug and a carrier is better; the solubility is taken as an investigation target, screening of a vitamin E inclusion material and auxiliary materials is carried out, and the optimal formula is selected for preparation of the vitamin E eutectic inclusion compound. Results show that the method effectively improves the physicochemical properties such as solubility of the fat-soluble vitamin E, is low in energy consumption, uses less toxic and harmful reagents, and has multiple advantages in expanded production. Therefore, the method has wide application potential and is of great significance to preparation methods of vitamin drugs.

This invention discloses a parenteral nutrition solution preparation and delivery device, comprising a first mixing component, a second mixing component, a third mixing component, a secondary mixing chamber, a transfer chamber, a tertiary mixing chamber, and a frame. The first mixing component mixes phosphate-free electrolytes, water-soluble vitamins, and trace elements into a compound amino acid solution. The second mixing component mixes phosphates into a glucose solution. The third mixing component mixes fat-soluble vitamins into a fat emulsion. The secondary mixing chamber further mixes the mixed amino acid solution and the mixed glucose solution. The transfer chamber agitates the mixed solution to ensure thorough mixing. The tertiary mixing chamber adds the fat emulsion containing fat-soluble and water-soluble vitamins to the amino acid and glucose mixture. This device, through the coordinated operation of its components, enables the rapid and accurate preparation of large quantities of parenteral nutrition solution, and the preparation process is carried out within a sealed container, preventing contamination of the nutrient solution by the external environment.