381 results about "Fat-Soluble Vitamin" patented technology

This invention pertains to therapeutic antibacterial / antifungal-wound healing compositions comprise a therapeutically effective amount of antibacterial agents and / or antifungal agents and / or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide and (b) fat-soluble vitamins. The therapeutic antibacterial / antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the antibacterial / antifungal-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.

This invention pertains to therapeutic antibacterial / antifungal-wound healing compositions comprise a therapeutically effective amount of antibacterial agents and / or antifungal agents and / or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide and (b) fat-soluble vitamins. The therapeutic antibacterial / antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the antibacterial / antifungal-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.

Aqueous liquid or gel formulations of fat soluble vitamins, essential nutrients and other pharmaceutical agents have enhanced concentration of the active components relative to known compositions and therefore have enhanced bioavailability. The aqueous solutions or gels form a free flowing powder when they are absorbed on a suitable pharmaceutically acceptable solid carrier, such as silicon dioxide, maltodextrin, magnesium oxide, aluminum hydroxide, magnesium trisilicate, starch or sugars, or encapsulated by polymers such as gelatin, pectin, chitosan and the like.

The invention mainly discloses vitamin powder and a preparation method of the vitamin powder. The vitamin comprises the following components in mass percentage: 5-60% of fat soluble vitamin, 30-70% of wall material, 5-30% of assistant wall material, 0.5-2% of emulsifier, 0.1-2% of antioxidant and 0.1-3% of cross linking agent. The invention further relates to a preparation method of the vitamin powder. By using a microencapsulation technique, the fat soluble vitamin oil (e.g. vitamin A, vitamin D3, vitamin E and vitamin K) is embedded to a micro-capsule, the wall material used in the embeeding process is starch sodium octenylsuccinate, the vitamin oil is embeeded in the wall and then the micro-capsule is subjected to cross linkage, mist spraying and drying are carried out to form the vitamin powder, and the embedding rate of the vitamin is more than 95.3%. According to the invention, the process is simple, the cost is low, the obtained vitamin powder is not soluble in water, high in oil loading amount and good in flowability, and can be used in the fields such as foods, daily-used industrial chemicals and medicines.

The invention discloses a preparation method and the production process of a complex injection of 13 vitamins. The injection adopts dual-injection type, the invention overcomes the problem of solubility of the fat-soluble vitamins in water, so the invention can be prepared into the water injection; the stability of the product is good, and various vitamins can not be affected mutually. The injection includes water-soluble vitamins, fat-soluble vitamins, surfactant, antioxidant, complexing agent and solvent, the injection water is added till the dissolution, the activated carbon is added for absorption, the pH value of the solution is regulated, and then the nitrogen filling and sterilization are carried out. The production process of the invention prepares the injection into dual-injection type, the vitamin B12, folic acid and biotin have an independent package, the process overcomes the problem of solubility of fat-soluble vitamins in water, the invention can be prepared into water injection, the stability of the product is good, and various vitamins can not be affected mutually, the vitamins can be added in a large infusion for usage, so as to avoid the trouble of redissolution and reuse of the freeze-dried powder injection.

This invention pertains to therapeutic antibacterial / antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and / or antifungal agents and / or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide; (b) calcium channel blocker, and (c) fat-soluble vitamins admixed with antibacterial and antifungal agents. The therapeutic antibacterial / antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products and administered orally or topically.

A freeze-dried liposoluble vitamin with high water solubility and stability and its preparing process is also disclosed.

The invention discloses an emulsion gel in which fat-soluble vitamins are embedded and a production method based on a pulse electric field. The production method includes the following steps: dissolving octenyl succinic acid modified starch in water, heating in a water bath, stirring until the material is completely gelatinized and dissolved, and cooling to room temperature; adding edible oil in which fat-soluble vitamins are dissolved to obtain a mixed solution; using a high-speed shearing machine and a high-pressure homogenizer to shear and homogenize the obtained mixed solution so as to a coarse emulsion; adding starch into the coarse emulsion, and uniformly stirring to obtain an emulsion; adding a methylcellulose solution to the emulsion, uniformly mixing and performing pulse electricfield treatment, heating in a water bath, degassing, and cooling to obtain an emulsion gel. The pulsed electric field of the invention promotes the interaction between methylcellulose and starch molecules, has a higher elastic modulus, and is easier to form a network structure that is more favorable for embedding fat-soluble vitamins. Thereby, fat-soluble vitamins are effectively embedded, and thepurpose of slowly releasing fat-soluble vitamins is achieved.

The invention relates to a special clinical nutrient formula for diabetes and a preparation method thereof. The special clinical nutrient formula comprises the following raw materials of 20 to 40 parts of protein, 10 to 20 parts of fat, 25 to 45 parts of carbohydrate, 4 to 10 parts of dietary fiber, 0.6 to 1.2 parts of macroelement, 0.01 to 0.03 part of trace elements, 0.002 to 0.02 part of fat-soluble vitamin, 0.005 to 0.02 part of water-soluble vitamin, 0.1 to 0.6 part of dietary essence, 0.5 to 6 parts of medicinal and edible component, 0.1 to 1 part of natural plant compound and 0.005 to 0.2 part of new resource food, wherein the medicinal and edible compound is selected from at least one of rhizoma polygonati, fermented soybean, folium mori, Chinese yam, hawthorn fruit, liquorice root, platycodon grandiflorum, and folium nelumbinis; the components are prepared into powder in advance, and the fat is treated by a micro-capsule embedding technique, so as to prepare oil powder. The special clinical nutrient formula has the advantages that by screening and proportioning the components, the required energy, key nutrients and necessary trace elements are provided for a diaberic; by adding the component with blood sugar decreasing effect, the blood sugar value of the diaberic is reduced, and the risk of diabetes is decreased.

The invention discloses cereal-free and low-sensitization pet puffed food containing rich probiotics and a preparation method of the puffed food. The puffed food is prepared from raw materials in parts by weight as follows: 50-85 parts of fresh low-sensitization meat or meat meal, 1-40 parts of non-cereal starch, 5-20 parts of fresh fruits and vegetables, 1-20 parts of chicken fat or duck fat, 1-20 parts of linseed oil, 1-10 parts of Jerusalem artichoke powder, 1-10 parts of beer yeast, 1-10 parts of compound water-soluble vitamins and minerals, 1-10 parts of compound fat-soluble vitamins and 1-10 parts of compound probiotics. The prepared pet food has balanced and comprehensive nutrients and good palatability and contains no sensitization cereal materials such as corn and wheat. Meanwhile, the compound probiotics are added in a spraying manner, after pets eat the food, the effects of the probiotics are played, beneficial flora is regulated in digestive tracts of the pets, absorption of nutrients is promoted, metabolism and immunity are enhanced, and allergy of the pets is relieved.

The invention relates to a stable compound containing a plurality of vitamins and the method for preparing same. The compound comprises at least four kinds of fat-soluble vitamin, cholate, phosphatide and carriers or findings acceptable by pharmacy. The compound also comprises water soluble vitamins. The compound is a clear and transparent solution. The preparing method comprises: (1) dissolving the fat-soluble vitamin with liquid containing ethanol; (2) removing ethanol. The compound is used as nutriment for patients.

The invention belongs to the field of feed additives, and mainly relates to a multivitamin aqueous solution preparation, in particular to a stable aqueous solution preparation containing fat-soluble vitamins and water-soluble vitamins.

The invention relates to a special clinical nutrient composition for gestational diabetes and a preparation method of the nutrient composition. The composition comprises 20-35 parts of protein, 8-15 parts of fat, 25-40 parts of carbohydrate, 3-8 parts of dietary fiber, 0.6-1.2 parts of macroelements, 0.01-0.03 parts of microelements, 0.005-0.015 parts of fat-soluble vitamins, 0.08-0.2 parts of water-soluble vitamins, 0.05-0.6 parts of dietary essence, 0.5-4 parts of medicinal and edible components, 0.1-1 part of natural plant compounds and 0.1-0.4 parts of new resource food, wherein the medicinal and edible components are selected from at least one of Chinese yams, black sesame, radix puerariae, rhizoma polygonate, folium mori, fructus lycii, radix platycodonis and lilies; powder is prepared from the components in advance, and grease powder is prepared from fat with a microencapsulating technology. Through sieving and proportioning of the components, the nutrient composition can provide comprehensive nutrition for patients suffering from gestational diabetes, and digestion and absorption are facilitated; besides, the components with the blood glucose reducing function are added to assist in reducing the blood glucose level of the gestational diabetes and the disease risk, and growth demands and normal development of fetuses are guaranteed.

The invention discloses a complex vitamin molecule microemulsion and a preparation method thereof. In terms of the formula, the complex vitamin molecule microemulsion comprises the following components (in weight ratio): 2.0-10.0g of fat soluble vitamin, 37-100g of solubilizer, antioxidant, 7.5-20g of emulsion, 80-200g of assistant emulsifier, 10.0-100.0g of water soluble vitamin, 10-50g of multiple amino acids and 550-750ml of purified water. The complex vitamin molecule microemulsion disclosed by the invention has the advantages of high stability, high solution, high absorption, high nutrition and good promotional value.

The invention discloses a method for measuring 9 fat-soluble vitamins in blood serum by UPLC (Ultra Performance Liquid Chromatography). The 9 fat-soluble vitamins respectively are vitamin A, alpha-tocopherol, gamma-tocopherol, delta-tocopherol, alpha-carotene, beta-carotene, a coenzyme Q10, lycopene and lutein. A UPLC instrument is adopted to detect the 9 fat-soluble vitamins in the preprocessed blood serum and by comparing a response value of a sample with a value of a standard substance, the content of the 9 fat-soluble vitamins is calculated. The method disclosed by the invention has the advantages that the sample is saved and 200 microliters of sample can implement analysis on the 9 fat-soluble vitamins; time is saved, nine target components with different optimal adsorption wavelengths are integrated into one scheme and separation analysis can be completed in 12.5 minutes; the cost is saved and consumption of a great amount of organic reagents and loss of an instrument are avoided.

The invention relates to a clinical nutrient formula special for tumor and a preparation method of the clinical nutrient formula. The clinical nutrient formula is prepared from the following raw materials: proteins, fat, a carbohydrate, dietary fibers, macroelements, trace elements, fat-soluble vitamins, water-soluble vitamins, a medicinal and edible component, a natural plant compound and new resource food, wherein the medicinal and edible component is selected from at least one of hawthorns, sea-buckthorn, poria cocos, sealwort, chrysanthemum, dandelion, lilies and fermented soybean; all the components are prepared into powder; the fat is prepared into powdered oil by adopting a micro capsule embedding technology. Due to screening and proportioning of the components, the nutrient formula disclosed by the invention can supply comprehensive nutrition support to a tumor patient and substantially increase the biological value of the proteins; moreover, due to the adding of the components capable of enhancing the immunity and resisting the tumor, the physique of the tumor patient can be enhanced, and malnutrition which possibly occurs or exists can be prevented or corrected; the nutrition supporting effect is enhanced, so that the patient can bear a complete chemotherapy process.

The present invention relates to a suspension emulsion gel loaded with fat-soluble vitamins and a preparation method thereof, and belongs to the technical field of food processing. The suspension emulsion gel comprises the following components in parts by weight: 1-10 parts of fat-soluble vitamins, 1-10 parts of vegetable proteins, 0.5-3 parts of polysaccharides and 30-60 parts of vegetable oil rich in unsaturated fatty acids. The preparation raw materials are cheap in source, safe, good in biocompatibility, fast in biodegradation and easy for modification. The prepared suspension emulsion gelhas good stability, is simple in technology, low in cots, safe, environmentally protective, good in product stability and high in bioavailability, can be used in various foods to enhance sensory value, edible value and nutritional value, and can also be used for preparing healthy functional foods or healthy accessory ingredients.

The present invention provides colloidally stable dispersions of nanoparticles comprising beta-lactoglobulin and a polysaccharide which are transparent when diluted in aqueous media. In particular these colloidally stable dispersions of nanoparticles are useful as delivery vehicles of hydrophobic nutraceuticals and fat-soluble vitamins, for enrichment of food products, especially of transparent beverages and other non-fat or low fat foods and drinks. The present invention further provides methods for the preparation of said colloidally stable dispersions.

The invention provides a clinical nutrient formulation special for sarcopenia, comprising, by weight, 18-30 parts of proteins, 9-13 parts of fat, 40-52 parts of carbohydrates, 4-8 parts of dietary fibers, 0.6-1.2 parts of macro elements, 0.01-0.03 part of trace elements, 0.005-0.02 part of fat-soluble vitamins, 0.005-0.20 part of water-soluble vitamins, 0.2-1 part of dietary essences, 0.07-4 partsof medicinal and edible ingredients, 0.1-1 part of natural plant compounds, and 0.03-0.6 part of new resource foods. The invention also provides a preparation method of the clinical nutrient formulation special for sarcopenia. The clinical nutrient formulation special for sarcopenia herein can meet the demand of a patient with sarcopenia for comprehensive balanced nutrition, can also improve bodyquality of the patient with sarcopenia and promote myodynamia recovery and muscle regeneration.

The invention relates to a silk fibroin nano-fiber film loaded with vitamins A and E and a preparation method thereof. The nano-fiber film comprises silk fibroin nano-fiber, as well as the fat-soluble vitamin A and the water-soluble vitamin E, which are loaded in the silk fibroin nano-fiber. The preparation method comprises the following steps of: (1) heating the vitamins A and E till melting, uniformly stirring, then adding deionized water at the temperature of 80-100 DEG C, and stirring for 10-20min till transparent liquid, namely an emulsion of the vitamins A and E, is formed; (2) adding silk fibroin and the deionized water into the emulsion of the vitamins A and E till the final concentration, and stirring till the complete solution of the silk fibroin so as to get a mixed solution of the three; and (3) transferring the solution into a syringe for performing electrostatic spinning to get the silk fibroin nano-fiber film. The silk fibroin nano-fiber film disclosed by the invention has the advantages of no pollution, low cost and simple operation, and the nano-fiber disclosed by the invention can be applied to artificial skin, medical dressings, hemostatic materials, skin care products and other various biomedical fields.

The invention relates to a medicinal compound of fat-soluble vitamin injection (II) and a water-soluble vitamin for injection, in particular to a combined application package. The medicinal compound comprises the fat-soluble vitamin injection (II) and the water-soluble vitamin for the injection. When in use, the medicinal compound is dissolved or thinned by using water for the injection or glucose injection liquid first, and then is respectively instilled in a venous way. By using the combined application package provided by the invention, the vitamins needed by a human body are comprehensively replenished; the defects caused by the usage of a single vitamin are avoided; and the treatment effect is improved greatly.

The invention relates to a special clinical nutrition formula for gestational hypertension and a preparation method thereof. The special clinical nutrition formula comprises the following components: 25-35 parts of protein, 8-15 parts of fat, 35-45 parts of carbohydrate, 3-8 parts of dietary fiber, 0.6-1.2 parts of macroelement, 0.01-0.03 part of trace element, 0.005-0.02 part of fat-soluble vitamin, 0.08-0.2 part of water-soluble vitamin, 0.5-5 parts of dietary essence, 0.5-5 parts of medicinal-edible component, 0.1-1 part of natural plant compound and 0.1-0.4 part of new resource food, wherein the medicinal-edible component is at least one of flos chrysanthemi, sophora japonica, lotus leaf, wolfberry, oyster, phyllanthus emblica and radix puerariae; the components are made into powder in advance; the fat is made into powdered oil by a micro-capsule embedding technology. Through the screening and proportioning of the components, the nutrition formula provided by the invention can meet the comprehensive needs of a gestational hypertension patient; and meanwhile, by adding the component with a blood pressure reducing function, the blood pressure value of gestational hypertension is lowered, the risk of gestational hypertension is reduced, and the growth needs and normal development of a fetus are guaranteed.

The invention relates to a special clinical nutritional formula for male sterility. The special clinical nutritional formula is prepared from 15-40 parts of protein, 2-8 parts of fat, 40-55 parts of carbohydrates, 5.8-8 parts of dietary fibers, 0.6-1.2 parts of major elements, 0.01-0.04 part of minor elements, 0.005-0.02 part of fat-soluble vitamins, 0.008-0.2 part of water-soluble vitamins, 0.05-1 part of dietary essence, 0.1-2 parts of medicine-food homologous ingredient, 0.1-3 parts of natural plant compound and 0.005-5 parts of new resource food, wherein the medicine-food homologous ingredient is at least one selected from poria cocos, red raspberries, lycium barbarum, dioscorea opposita, wild jujube seeds, oysters and radix glycyrrhizae; all the ingredients are prepared into powder in advance, and the fat and the vitamins are prepared into powder by adopting a microcapsule coating technology. Through screening and proportioning the ingredients, the nutritional formula provided by the invention provides a more reasonable and more comprehensive nutritional support for male sterility sufferers so as to improve potential and occurred malnutrition state; meanwhile, kidney tonifying, spleen invigorating and liver soothing ingredients are added, so that the body condition of the male sterility sufferers is improved, the sperm production capability is promoted, and the sperm viability is improved.

The invention relates to a composite vitamin functional additive and a preparation method thereof, and belongs to the technical field of cultivation nutrition and prevention and treatment of diseases. The additive is prepared from ginseng polysugar, lentinan, various functional vitamins (including fat-soluble vitamin and water-soluble vitamin), amino acid and Chinese herb extract. The preparation method includes the steps that the extracted ginseng polysugar and the lentinan are added into a composite vitamin premix compound for beasts and birds to be mixed; the ginseng polysugar accounts for 8%-10% of the composite vitamin premix compound for beasts and birds, the lentinan accounts for 5% of the composite vitamin premix compound for beasts and birds, and the vitamin mixture accounts for 85%-87% of the composite vitamin premix compound for beasts and birds. By the adoption of the additive, the feed intake and the daily adding weight of beasts and birds can be effectively increased, the vital movement of beasts and birds is maintained, the immunity, disease resistance and anti-stress capacity are improved, nutritional deficiency diseases are prevented, feed consumption is reduced, toxic and side effects are avoided, no adverse effect on the environment is caused, and the utilization rate of the raw materials is greatly increased.

The present invention relates to a vitamin A liposome artificial tears eye drops for preventing and curing xerophthalmia and ophthalmokopia. Its composition includes fat-soluble vitamin A, liposome encapsulating material, vitamin E and artificial tears hydrated liquor, in which the fat-soluble vitamin A is vitamin A palmitate or vitamin A acetate, the liposome encapsulating material is soya bean lecithin and cholesterol, and the composition of artificial tears hydrated liquor includes sodium hydrogen carbonate, sodium chloride, glucose, potassium chloride, calcium chloride and water. Besides, according to requirements one or several kinds of auxiliary components of menthanol, PVP and HPMC, etc. also can be added.

Here described are compounds of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleyl group; wherein R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; wherein X is selected from a group consisting of -CH2-, -S-, and -O- or absent; wherein Y is selected from -(CH2)n, -S(CH2)n, -O(CH2)n-, thiophene, -SO2(CH2)n-, and ester, wherein n = 1 -4; wherein a = 1 -4; wherein b=l -4; wherein c=l-4; and wherein Z is a counterion; and compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including one or both of these compounds which are useful for the delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.

The invention discloses a method and a sample pretreatment method for detecting a content of fat-soluble vitamins in formula milk powder. The invention firstly discloses the sample pretreatment methodfor detecting the content of the fat-soluble vitamins in the formula milk powder, and the method comprises the following steps of weighing a to-be-detected formula milk powder sample, and adding ascorbic acid, absolute ethyl alcohol and a KOH solution for saponification; adding n-hexane into the solution after saponification, centrifuging after liquid-liquid extraction, and collecting supernatantliquid; and drying the supernatant liquid, re-dissolving and filtering to obtain a to-be-detected solution. The invention also further discloses the method for detecting the content of the fat-soluble vitamins after sample pretreatment through an ultra-high performance liquid chromatography-triple quadrupole mass spectrometry technology. The method disclosed by the invention is easy, rapid, sensitive and accurate, and can meet the detection requirements for the fat-soluble vitamins in the formula milk powder.

The present invention provides novel, simple and reliable methods for extraction of fat soluble vitamins (FSVs) from a sample matrix obtained from food products (e.g., vitamin-enriched foods and fortified food matrices) or biological samples. In certain aspects, the invention provides solid phase extraction (SPE) methods. In certain embodiments, the invention relates to two-step elution methods, which provide excellent recovery of all fat-soluble vitamins from complicated food matrices (such as, vitamin-enriched foods and fortified food products) or biological samples in a simultaneous manner. In certain embodiments, the invention uses OASIS® materials as sorbent beds for separating and / or extracting FSVs from the sample matrix.