198 results about "Vitamin a1" patented technology

The invention discloses a method for improving beef quality, an action mechanism and an experimental method, in a cattle body, vitamin A can activate the expression of EBF2 through an active metabolite RA of the vitamin A, and the EBF2 can inhibit the transcription process of CYP26B1 in a targeted manner to maintain the activity of a retinol signal channel, so that PPAR gamma and downstream lipid metabolism related genes thereof are activated, and the activity of the retinol signal channel is improved. Fatty acid transport and lipid accumulation in fat cells in the cattle muscle are promoted, fat deposition in the cattle muscle is promoted, and the beef quality is improved. By constructing the molecular network for regulating and controlling the formation of the fat in the cattle muscle, a complex regulation and control mechanism for controlling the fat deposition in the cattle muscle can be understood more deeply, a method for improving the beef quality based on regulating and controlling the vitamin A mediated key factor EBF2 is provided, and a new way is provided for improving the beef quality in a targeted manner.

The invention relates to the technical field of exosomes, in particular to an exosome compound preparation with a hair growing effect and a preparation method of the exosome compound preparation. Comprising 12 to 22 parts of ginsenoside Rb1, 15 to 12 parts of biotin tripeptide-15, 8 to 15 parts of diammonium glycyrrhizinate, 50 to 70 parts of fish collagen peptide, 10 to 20 parts of soybean peptide, 0.5 to 4.5 parts of SHH protein, 0.5 to 2.5 parts of SMO inhibitor, 0.5 to 1.5 parts of HhSP protein, 5 to 10 parts of N-acetyl tyrosine, 0.1 to 2 parts of hyaluronic acid, 0.1 to 1 part of melatonin, 0.1 to 1 part of quercetin, 0.1 to 1 part of kaempferol, 0.1 to 1 part of tanshinone, 0.1 to 1 part of biotin and 0.1 to 1 part of vitamin A. The compound preparation is combined with exosomes from various sources, so that the hair papilla cell function is synergistically enhanced, and the damaged hair follicle structure is repaired.

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

The invention relates to application of 9-cis-retinoic acid in preparation of products for treating, preventing or improving obesity, and belongs to the technical field of biological medicine. Experimental evaluation of obese mice induced by high-fat diet proves that the 9-cis-retinoic acid can reduce blood fat and improve the glycometabolism function, and lipid accumulation of the liver is improved mainly by increasing expression of main regulatory protein PPAR-alpha oxidized by liver beta, so that the 9-cis-retinoic acid can be used for preparing medicines for treating obesity. The traditional Chinese medicine composition can be used for treating, preventing or improving metabolic symptoms caused by high fat diet, and a new strategy is provided for treating obesity and related metabolic syndromes. Besides, 9-cis-retinoic acid is a natural active metabolite of vitamin A, does not show obvious toxic reaction in animal experiments, and has better biocompatibility.

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

The present disclosure relates to the field of livestock farming, and specifically provides a feeding method for gilts in batch for promoting onset of puberty and alleviating estrus disorder of gilts, which is aiming at an industrial problem that a large number of gilts are culled due to delayed puberty onset or estrus disorder. The method includes: feeding, prior to onset of puberty for gilts with vitamin A combined with lactic acid; and performing, subsequent to the puberty onset of gilts, estrus synchronization treatment and insemination treatment on the gilts. By applying vitamin A combined with lactic acid, the present disclosure alleviates the delayed puberty onset or estrus disorder of the gilts, reduces the feeding duration and feeding cost of the gilts, facilitates synchronous estrus treatment of the gilts.

The invention discloses a qualitative and quantitative detection method for vitamin A and vitamin E in food. The qualitative and quantitative detection method comprises the following steps: step 1, pre-treating a sample and accurately adding an isotope internal standard: adding d6-alpha-tocopheryl acetate and d8-retinol acetate into the sample before saponification and preparing a blank matrix; 2, pre-treatment parameter QbD-DOE collaborative optimization, wherein a response surface method is adopted for conducting center composite design on the saponification temperature, time and BHT concentration, and the interaction effect of all the factors is analyzed to determine an optimal operation window; step 3, intelligently optimizing chromatography-mass spectrometry conditions and tuning parameters; step 4, constructing a matrix matching calibration curve and performing WLS quantitative analysis: performing gradient dilution on a standard substance by utilizing a blank matrix extracting solution, adding an isotope internal standard to prepare a 5-7-point matrix matching calibration curve, fitting the curve by adopting a weighted least square method, and verifying the correlation and intercept change of the calibration curve every day; and 5, multi-dimensional qualitative confirmation and intelligent diagnosis system operation.

The invention discloses ointment for preventing infantile hand-foot-and-mouth disease and a preparation method thereof. The ointment is prepared from coptis chinensis, sweet wormwood, honeysuckle, radix sophorae flavescentis, lithospermum, sanguisorba officinalis, radix isatidis, menthol, clove oil, vitamin A oil, vitamin E oil, roxburgh rose seed oil, olive oil, chamomile extract, honey and microcrystalline wax. On the basis of combination of traditional Chinese medicines and western medicines, traditional Chinese medicine components such as coptis chinensis, artemisia apiacea and honeysuckle and western medicine components such as vitamin A and vitamin E are combined, and the ointment for preventing the infantile hand-foot-and-mouth disease is prepared. The components have the effects of clearing away heat and toxic materials, resisting viruses, bacteria and inflammation and the like, and are beneficial to enhancing the immunity of the organism, inhibiting virus diffusion and relieving disease symptoms, so that the occurrence of the infantile hand-foot-and-mouth disease is effectively prevented.

The invention relates to the technical field of preparation of health-care products, in particular to a fat-soluble component nano-emulsion and a preparation method thereof. The preparation method comprises the following steps: stirring and dissolving the antioxidant and the caprylic / capric triglyceride, adding the vitamin D3 and the retinyl palmitate, and stirring and dissolving to obtain an oil phase; stirring the starch sodium octenylsuccinate in purified water until the starch sodium octenylsuccinate is dissolved, adding glycerol, and uniformly stirring and mixing to obtain a water phase; adding a small amount of water phase into the oil phase, and stirring at high speed to obtain primary emulsion; adding the primary emulsion into the residual water phase, stirring at a high speed, shearing and homogenizing to obtain a nano embedding emulsion; adding citric acid, cane sugar and sodium ascorbate into purified water, adding the nano embedding emulsion, and uniformly stirring to obtain a concentrated solution; and diluting the concentrated solution and adjusting the pH value to obtain the fat-soluble component nano-emulsion. The fat-soluble component nano-emulsion provided by the invention has good safety; the product can be easily absorbed and utilized by a human body, and is convenient for people to quickly supplement vitamin A and vitamin D3 required by the body.

The invention relates to the field of detection, in particular to a method for simultaneously detecting multiple fat-soluble vitamins, which comprises the following steps: (S.1) carrying out protein precipitation and liquid-liquid extraction on a sample to be detected to obtain an extract containing fat-soluble vitamins; (S.2) carrying out derivatization reaction on the extract by using a PTAD derivatization reagent; and (S.3) analyzing the derivatized product by adopting a liquid chromatography-tandem mass spectrometry method, wherein the detected target fat-soluble vitamins comprise vitamin A, vitamin E, 25-hydroxy vitamin D2, 25-hydroxy vitamin D3, vitamin K1, vitamin K2 and vitamin K2. According to the application, PTAD is creatively adopted as a unified derivatization reagent, simultaneous and efficient derivatization of seven fat-soluble vitamins is successfully realized, the detection sensitivity of low-content targets, especially vitamin D, K2 and the like, is greatly improved, and the core problems of weak signal response and difficulty in accurate quantification are solved.

The invention discloses a resource utilization method of low-quality C15 phosphonium salt. The preparation method comprises the following steps: (1) performing thermal decomposition reaction and isomerization reaction on the low-quality phosphonium salt to generate the C15 phosphonium salt; (2) adding a solvent into the reaction liquid obtained in the step (1) for extraction and phase separation, and collecting a product phase containing a C15 phosphine salt isomer; and (3) adding pentacaraldehyde and carbonate into the product phase containing the phosphonium salt, and carrying out condensation reaction to prepare the vitamin A acetate. According to the method, the low-quality phosphonium salt generated in the C15 phosphonium salt production process can be recycled, the produced low-grade vitamin A acetate is sold, the product mark is enriched, and the industrial competitiveness of the product is improved. The process is simple to operate, mild in reaction condition, green and environment-friendly, free of waste liquid and suitable for industrial production, and the industrial chain cost of the vitamin A acetate is greatly reduced.

The present application relates to the technical field of cosmetic raw materials, and provides tocopheryl retinoate and application thereof in cosmetics and / or skin care products. The tocopheryl retinoate introduces a tocopherol group with antioxidant activity into the molecular structure of retinoic acid, significantly improves the light stability and thermal stability of the compound while maintaining the biological activity of vitamin A ingredients, and effectively reduces the irritation to the skin. The tocopheryl retinoate is suitable for the cosmetic and / or skin care product system used in the daytime, can improve the skin condition, repair the skin barrier and protect the skin, and has good safety and wide application prospect.

The invention relates to the technical field of vitamin A micro-capsule production, in particular to a vitamin A micro-capsule and a preparation method thereof. Research finds that the roundness of the vitamin A micro-capsule prepared by the emulsion through a spray drying process can be controlled by controlling the size of a relational expression 0.88 * ln (Q) + 0.12 * e (-0.002 mu) * (N / 1000) 0.18-0.05 * Te-120 + 0.1 * (epsilon / 2.4) 0.5, the relational expression obtained through parameter calculation of the spray drying process is controlled to be 50% or above, the vitamin A micro-capsule with the roundness being 50% or above can be obtained, and the vitamin A micro-capsule with the roundness being 50% or above can be used for preparing the vitamin A micro-capsule with the roundness being 50% or above. The roundness of the vitamin A micro-capsule is remarkably improved, so that the situation that the micro-capsule is released too early in gastric juice is improved, the intestinal targeting property is improved, meanwhile, the situation that the micro-capsule is degraded in the storage period is improved, and the stability of the micro-capsule is improved.

The application discloses a method for promoting transport and improving retinal synthesis, which is obtained by introducing an exogenous ABC transport protein Pdr5 into a host fungus and adding a copy of beta-carotene-15, 15'-monooxygenase BLH; wherein the host fungus is a genetically modified Pichia pastoris strain PP-BCCIV. The application further verifies the retinal production performance of the recombinant strain by screening different surfactants, and further improves the ability of Pichia pastoris to produce retinal. At the same time, all the retinal is extracted into the extracellular, and all the carotenes are left in the intracellular, so as to achieve the co-production of carotenes and retinal. The recombinant Pichia pastoris of the application has a simple construction method, can better promote the synthesis of retinal and other vitamin A, and can make the engineering strain utilize glucose and methanol to efficiently synthesize retinal through a 5 L fermentation tank, which is beneficial to industrial production.

The invention provides a preparation method of a cholestatic liver injury animal model, which comprises the following steps: on the basis that a mouse is fed with a feed containing 500IU / kg vitamin A for 8 weeks to cause deficiency of vitamin A in the mouse body, performing intragastric administration of alpha-naphthyl isothiocyanate (ANIT) at 50mg / kg for 4 weeks once a week, so as to obtain the cholestatic liver injury mouse model. The blood biochemical index ALT, the liver index, the pathological structure change of the liver tissue and the bile acid deposition of the liver tissue are more obvious. The cholestatic liver injury model prepared by the preparation method can avoid the influence of inconsistent dosage and unstable model in a conventional method, and can be applied to the research fields of molecular mechanism research of occurrence and development of cholestatic liver injury, finding of cholestatic liver injury treatment medicines and methods and the like.

The invention provides a preparation method of high all-trans vitamin A. The reaction liquid continuously passes through a fixed bed-kettle series reactor loaded with a catalyst to carry out isomerization reaction, so that a vitamin A 11-cis-isomer and a vitamin A 9-cis-isomer can be efficiently converted into all-trans vitamin A, the isomerization selectivity is improved, and the yield of the all-trans vitamin A is improved. And the problem of excessive VA conversion in actual production is effectively solved.

The application discloses a method for vitamin A isomerization, and particularly relates to a method for generating all-trans vitamin A by performing isomerization reaction on VA crude oil in a solvent in the presence of a palladium catalyst, an alcohol amine type auxiliary agent and a diphenyl phosphine type auxiliary agent under an inert atmosphere. The method can efficiently isomerize 13-cis vitamin A into all-trans vitamin A while inhibiting the conversion of all-trans vitamin A into 9-cis vitamin A. After the reaction is completed, the conversion rate of 13-cis vitamin A is greater than or equal to 95%, the selectivity of all-trans vitamin A is greater than or equal to 99%, and no 9-cis vitamin A is generated.

The invention relates to the technical field of prebiotic liquid for livestock and poultry, in particular to prebiotic liquid for livestock and poultry and a preparation method and application of the prebiotic liquid for livestock and poultry. The prebiotic liquid is prepared from radix astragali, herba leonuri, radix acanthopanacis senticosi, vitamin E, vitamin A, vitamin D, vitamin C and water according to a specific proportion. Wherein 1500g of the prebiotic liquid contains 350g-550g of astragalus membranaceus, 250g-450g of leonurus, 250g-450g of acanthopanax, 0.15 g-0. 3g of vitamin E, 2500-4500IU of vitamin A, 250-450IU of vitamin D, 50g-100g of vitamin C and the balance of water. The preparation method comprises the following steps: pretreating raw materials, extracting effective components of traditional Chinese medicinal materials, dissolving and adding vitamins, fixing the volume, uniformly mixing, sterilizing, sub-packaging and storing. Through scientific proportioning of the traditional Chinese medicinal materials and the vitamins, the intestinal health and organism immunity of livestock and poultry are improved, and meanwhile, the extraction rate of effective components of the traditional Chinese medicinal materials is increased, the stability of the vitamins is ensured, and the shelf life of the product is prolonged by optimizing an extraction process, controlling vitamin adding conditions, adopting pasteurization, sealing storage in a dark place and the like.

The invention relates to a livestock breeding technology, and discloses a preparation method of a premix for enhancing laying hen production treatment, in the construction of a basic nutrition framework, the construction of a vitamin system is a core project, vitamin A is supplemented by adopting a palmitate form, the stability of the vitamin A in feed processing is ensured, the level of 8000-12000IU should be maintained in each kilogram of feed, and the content of the vitamin A in the feed processing is reduced. According to the fallopian tube mucous membrane composition, the addition amount of the vitamin D3 in the metabolic activity form of 25-hydroxyD3 needs to reach 2000-3000 IU / kg, the vitamin D3 and parathyroid hormone have a synergistic effect, the calcium and phosphorus deposition efficiency can be remarkably improved, particularly, the synergistic effect of B vitamins is worthy of attention, and thiamine (B1) and riboflavin (B2) are compatible according to the proportion of 1: 2. According to the preparation method of the premix for enhancing laying hen production treatment, the growth speed and the laying efficiency of chicken flocks are effectively improved, the eggshell quality is ensured, nutritional diseases such as chondropathy and egg reduction diseases are reduced, and the economic benefits of laying hen breeding are greatly improved.

The present invention concerns a diagnostic device and method for detecting thiamine and Vitamin A deficiencies using salivary biomarkers. The device utilizes a lateral flow assay to detect secretory Immunoglobulin A (sIgA) and amylase in saliva, providing a non-invasive, easy-to-use, and reliable method for assessing nutritional deficiencies. This invention is particularly useful for monitoring health status in populations with limited access to medical facilities.

The invention belongs to the technical field of nutrient solutions, and particularly relates to a concentrated nutrient solution helpful for improving special nutritional ingredients of animals and having health-care efficacy, the concentrated nutrient solution is prepared from the following components: composite small molecule peptides, composite vitamins, composite minerals, composite amino acids and fructo-oligosaccharide; wherein the composite small molecule peptide is formed by mixing fish skin oligopeptide, sea cucumber peptide and corn oligopeptide; the compound vitamin is formed by mixing vitamin A, vitamin B12, vitamin C and vitamin D3; the composite mineral substance is formed by mixing calcium lactate, calcium hydrophosphate, ferrous sulfate and zinc sulfate; the compound amino acid is formed by mixing lysine, methionine, threonine and tryptophan. The fish skin oligopeptide, the sea cucumber oligopeptide and the corn oligopeptide in the composite small molecule peptide can achieve a synergistic effect, can promote growth of young broilers, can promote nutrient absorption and can reduce feed consumption; in addition, the immunity of the chick broiler chicken can be improved, so that the survival rate is increased.

The present invention provides pharmaceutical compositions comprising a therapeutically effective dose of vitamin A palmitate; processes for their preparation, and uses and methods of treatment comprising them. The compositions provided by the present invention may be used in the treatment and / or prophylaxis of conditions and diseases caused by vitamin A deficiency.

The invention belongs to the technical field of experimental animal nutriology and sterile animal culture, and particularly relates to a vitamin compound for prolonging the survival time of sterile zebra fish and a preparation method of the vitamin compound. The vitamin compound is prepared from the following components in parts by mass: 600 to 1000 parts of vitamin A, 4000 to 6000 parts of vitamin C, 10 to 30 parts of vitamin D3, 1500 to 2200 parts of vitamin E, 80 to 120 parts of vitamin K3, 15000 to 25000 parts of compound B vitamins and sterile culture water. The preparation method comprises the following steps: dissolving the vitamin raw materials in sterile culture water, performing ultrasonic assisted dissolution, and then filtering and sterilizing to obtain the vitamin supplement. When the vitamin supplement is used for feeding the sterile zebra fish, the survival time of the sterile zebra fish can be obviously prolonged, and the expression level of growth hormone genes and insulin-like growth factor genes can be up-regulated. The application value of the sterile zebrafish in scientific research is further expanded.

The application relates to the embedding technical field, and particularly discloses a double emulsion gel bead embedding beta-carotene and probiotics and a preparation method thereof. The double emulsion gel bead comprises a composite layer, an oil phase and an inner water phase from outside to inside. The composite layer comprises an outer water phase and calcium alginate which are fused with each other. The outer water phase comprises a product after carrageenan and sodium caseinate are subjected to a Maillard reaction. The oil phase comprises beta-carotene, vegetable oil and a food emulsifier. The inner water phase comprises probiotics. In the gel bead, the beta-carotene and the probiotics are simultaneously embedded in the double emulsion gel bead, the calcium alginate hydrogel shell starts to decompose when entering the intestinal tract, then the double-layer emulsion is slowly decomposed after being subjected to chemical digestion of pancreatic juice, bile and small intestinal juice and mechanical digestion of the small intestine in the small intestine, and the beta-carotene and the probiotics are gradually released, the beta-carotene is converted into vitamin A in the intestinal tract and is absorbed, and the probiotics are delivered to the colon to play a probiotic effect.

The invention discloses a compound immunopotentiator and application thereof in prevention and control of aquatic diseases, and belongs to the technical field of aquaculture. The compound immunopotentiator is prepared by scientifically compounding eucommia ulmoides, astragalus membranaceus, curcumin, vitamin A, vitamin D3, vitamin E and vitamin K3. According to the compound immunopotentiator, through the synergistic effect of the Chinese herbal medicine extract and the compound vitamins, the autoimmunity of aquaculture animal bodies can be remarkably improved, the resistance of the aquaculture animal bodies to pathogenic microorganisms and bad environments is enhanced, the compound immunopotentiator further has a good pathogen removing effect, and damage of pathogens to the aquaculture animals can be effectively reduced. The compound immunopotentiator provided by the invention is used as a combination of a plant-derived drug and multivitamins, has no problems of environmental pollution and drug resistance, and is good in safety and effectiveness.

The invention provides a composition. The composition is prepared from vitamin A, vitamin D, vitamin E, vitamin K and health-care food or food-acceptable auxiliary materials according to specific proportions and doses. The anti-osteoporosis health-care food has the advantages that the vitamin components have a synergistic effect in the aspect of anti-osteoporosis, and the anti-osteoporosis health-care food can increase bone mineral density and maintain bone mass. In addition, the composition disclosed by the invention can also be used for precise nutritional supplement of specific crowds.

The invention discloses a composite vitamin composition for improving pet hair quality and pet feed, and each kilogram of feed comprises the following components: 6000 IU to 12000 IU of vitamin A; 20 mg to 80 mg of vitamin E; 4 mg to 8 mg of vitamin B2; 10 mg to 30 mg of vitamin B5; 0.4 mg to 0.8 mg of vitamin B7; and the content of vitamin C is 100 to 200 mg. According to the technical scheme, all the components have a synergistic effect, so that pet hair is vigorous and glossy, and the problems of hair embrittlement, dryness and the like are solved.

The present application belongs to the technical field of fermentation engineering, and particularly relates to a sheep liver peptide composition and a preparation method thereof, which are helpful for tonifying qi and blood and relieving dysmenorrhea. The sheep liver peptide composition comprises the following components in mass fractions: sheep liver peptide powder 60-70 parts, red date powder 5-15 parts, ginger powder 3-8 parts, licorice powder 3-8 parts, rose powder 2-6 parts, inulin 5-10 parts, astragalus peptide 5-10 parts, polygonatum kingianum peptide 5-10 parts, pepper powder 1-3 parts, cassia powder 1-3 parts, turmeric powder 2-5 parts, vitamin C 0.5-2 parts, and vitamin E 0.5-2 parts. The sheep liver peptide powder prepared by the present application has high contents of protein, total amino acids, free amino acids and vitamin A. The sheep liver peptide composition prepared by compounding the sheep liver peptide powder with the other components has the effects of tonifying qi and blood and relieving dysmenorrhea.

The present application relates to the technical field of nutritional supplement food, more specifically, to a double-protein balanced type of old-age nutritional supplement food and a preparation method thereof. The food comprises calcium, magnesium, zinc, iron, vitamin C, vitamin B6, vitamin E, vitamin B2, sodium selenite, nicotinamide, vitamin D3, vitamin A, vitamin B12, folic acid, vitamin B1 and vitamin K2. The present application is targeted at physiological characteristics and metabolic rules of middle-aged and old people, and scientifically proportioned various vitamins, minerals, essential fatty acids and antioxidant substances required by human body, so as to fully meet daily nutritional requirements of the middle-aged and old people and make up for insufficient dietary intake caused by decreased digestive and absorptive functions.

The invention discloses a whitening and brightening composition and a cosmetic thereof. The whitening and brightening composition is prepared from ascorbyl tetraisopalmitate, tranexamic acid, Brigtenyl, LightSKN CN, a resveratrol fermentation product, fermented lotus essence and super vitamin A, brigtenyl is a mixture composed of a first solvent, glycerin and diglucosyl gallic acid; lightSKN CN is a mixture composed of a second solvent, 1, 3-propylene glycol, xanthophyll, lecithin, sodium ascorbate and vitamin E; the resveratrol fermentation product is a mixture composed of a third solvent, a pichia pastoris fermentation lysate filtrate and resveratrol; the fermented lotus seed essence is a mixture composed of a fourth solvent, butanediol and a lotus seed extract; the super vitamin A is a mixture of isosorbide dimethyl ether and hydroxyl pinacolone retinoate. The whitening and brightening composition not only can inhibit melanin generation, reduce melanin transfer and accelerate melanin metabolism, but also can remove excessive free radicals in skin, so that the effects of long-acting skin whitening and skin brightening are achieved.