The invention provides a multi-vitamin supplement tablet applicable to menopausal women. The multi-vitamin supplement tablet applicable to the menopausal women is characterized by comprising 0.5mg of beta-carotene, 0.3mg of vitamin A, 15-25mg of vitamin B, 15-25mg of riboflavin, 15-25mg of niacin, 15-25mg of pantothenic acid, 15-25mg of vitamin B6, 0.15-0.25mg of biotin, 0.5mg of folic acid, 0.1mg of vitamin B12, 0.2mg of vitamin C, 0.3mg of vitamin D, 5 micrograms of vitamin E, 8 micrograms of vitamin K, 400mg of vitamin calcium, 150mg of magnesium, 15mg of iron, 8mg of zinc, 1mg of copper, 0.5mg of manganese, 0.5mg of molybdenum, 0.5mg of selenium, black Chinese wolfberry fruit extract, pomegranate extract, rhodiola rosea extract, ganoderma lucidum powder, concentrated royal jelly, minor ingredients and the like. The multi-vitamin supplement tablet applicable to the menopausal women is capable of meeting requirements of the menopausal women on vitamins and trace elements and has a certain treatment effect on the menopausal syndrome.