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Sanchi extract pellets and preparation method thereof

A technology of extract and Panax notoginseng, which is applied in the field of micropills made of Panax notoginseng extract and its preparation, can solve the problems of low bioavailability, irritation of gastric mucosa, long disintegration time, etc., and achieve bioavailability High, effective, reduce the effect of dosage and frequency of taking

Inactive Publication Date: 2010-05-12
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, products related to Panax notoginseng extract are very popular among consumers. These products are basically ordinary tablets and capsules. The mucous membrane has a certain degree of irritation, low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Prepare pellet formulations as follows:

[0034] (1) Take the Panax notoginseng extract of the above formula amount, add microcrystalline cellulose, pulverize to micronized level with a ball mill, and mix well;

[0035] (2) polyvinylpyrrolidone is dissolved in water;

[0036] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0039] Prepare pellet formulations as follows:

[0040] (1) Take the Panax notoginseng extract of the above-mentioned formula amount, add sucrose, pulverize it to a micronized level with a ball mill, and mix well;

[0041] (2) The binder hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0042] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0045] Prepare pellet formulations as follows:

[0046] (1) Take the Panax notoginseng extract of the above formula amount and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0047] (2) Polyvinylpyrrolidone is dissolved in an appropriate amount of water;

[0048] (3) The pellets are made by the centrifugal-fluidized pelletizing method.

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PUM

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Abstract

The invention provides sanchi extract pellets, which are prepared from a sanchi extract and medicinal accessories, and are characterized in that: the medicinal accessories comprise an excipient and a bonding agent; the sanchi extract accounts for 10 to 90 percent of the weight of the pellets; the excipient accounts for 4 to 89 percent of the weight of the pellets; and the bonding agent accounts for 1 to 6 percent of the weight of the pellets. The pellets can be made into a sustained-release or enteric-coated preparation. The sanchi extract pellets of the invention have high dissolution rate and high bioavailability. The method of the invention is simple, convenient and easy to operate.

Description

Technical field: [0001] The invention relates to a micropill of natural food extract and a preparation method thereof, in particular to a micropill made of Panax notoginseng extract and a preparation method thereof. Background technique: [0002] Panax notoginseng is the root of the Araliaceae plant Panax notoginseng (Burk.) F.H.Chen. Warm in nature, sweet in taste, slightly bitter. Functions and indications: dissipating blood stasis to stop bleeding, reducing swelling and relieving pain. Used for various internal and external bleeding, tingling pain in the chest and abdomen, swelling and pain from tumbling. "Compendium of Materia Medica New Edition" records: "Sanqi root is the magic medicine for hemostasis. Regardless of the blood in the upper, middle and lower blood, if there is a foreign body, it will be effective if it is used alone, and it will be even more effective if it is added to the qi and blood medicine. Covering this medicine can be nourishing without the tro...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/16A61P1/16A61P3/06A61P7/04A61P25/00A61P29/00A61P35/00A61P37/02A61P39/06
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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