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Mushroom extract sustained-release pellet and preparation method thereof

A technology of shiitake mushroom extract and slow-release pellets, which is applied in the directions of drug combination, digestive system, respiratory system diseases, etc., can solve the problems of low bioavailability point, irritation of gastric mucosa, long disintegration time, etc. Improved, less excipient dosage, good curative effect reproducibility

Inactive Publication Date: 2014-02-19
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The products of shiitake mushroom extract are well recognized by consumers. These products are basically ordinary tablets and capsules. However, the above-mentioned dosage forms have a long disintegration time and disintegrate at a certain point in the body, which has a certain effect on the gastric mucosa. Irritation, low bioavailability point and other shortcomings, based on the above problems, we will quickly introduce the pellet technology in the field of medicine to the field of food

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Lentinus edodes extract sustained-release pellets are prepared from lentinus edodes extract and pharmaceutical excipients, wrapped with a sustained-release film, which includes polymer materials, porogens and anti-adhesives, and the polymer material is B base cellulose; the porogen is polyvinyl alcohol; the anti-adhesive is silicon dioxide, the mushroom extract accounts for 22% of the weight percent of the pellet preparation, and the slow-release coating accounts for 2% of the weight percent of the pellet preparation. %, pharmaceutical excipients include starch and methyl cellulose, excipients account for 72% of the weight percentage of the pellet preparation, and adhesives account for 6% of the weight percentage of the pellet preparation.

[0017] The preparation method of mushroom extract sustained-release pellets comprises the following steps:

[0018] a. Take the extract of shiitake mushrooms, add medicinal excipients and mix evenly, prepare soft materials, and prep...

Embodiment 2

[0022] Lentinus edodes extract sustained-release pellets are prepared from lentinus edodes extract and pharmaceutical excipients, wrapped with a sustained-release film, which includes polymer materials, porogens and anti-adhesives, and the polymer material is B Base cellulose; Pore-forming agent is polyvinyl alcohol; Anti-adhesive is silicon dioxide, mushroom extract accounts for 28% of the weight percentage of pellet preparation, and slow-release coating accounts for 5% of the weight percentage of pellet preparation. %, pharmaceutical excipients include lactose and polyethylene glycol, excipients account for 63% of the weight percentage of the pellet preparation, and the weight percentage of the adhesive pellet preparation is 5%.

[0023] The preparation method of mushroom extract sustained-release pellets comprises the following steps:

[0024] a. Take the mushroom extract, add medicinal excipients and mix evenly, prepare soft materials, and prepare drug-containing pellets t...

Embodiment 3

[0028] Lentinus edodes extract sustained-release pellets, prepared from lentinus edodes extract and pharmaceutical excipients, coated with a sustained-release coating, the sustained-release coating includes polymer materials, porogens and anti-adhesives, the polymer material is ethyl Cellulose; Pore-forming agent is polyvinyl alcohol; Anti-adhesive is silicon dioxide, and mushroom extract accounts for 38% of the weight percentage of pellet preparation, and slow-release coating film accounts for 9% of the weight percentage of pellet preparation, Pharmaceutical excipients include dextrin and polyethylene glycol, excipients account for 55% by weight of the pellet preparation, and 3% by weight of the adhesive pellet preparation.

[0029] The preparation method of mushroom extract sustained-release pellets comprises the following steps:

[0030] a. Take shiitake mushroom extract, add medicinal excipients and mix evenly, prepare soft materials, and prepare drug-containing pellet cor...

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PUM

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Abstract

The invention discloses a mushroom extract sustained-release pellet. The mushroom extract sustained-release pellet is prepared from a mushroom extract and pharmaceutical adjuvant, and is coated with a sustained-release film; the sustained-release film comprises a polymer material, a pore forming agent and an adhesive resisting agent; the mushroom extract is 22-39% of the content of the pellet preparation in percentage by weight; the sustained-release film is 2-9% of the content of the pellet preparation in percentage by weight; the pharmaceutical adjuvant comprises an excipient and an adhesive; the excipient is 52-75% of the content of the pellet preparation in percentage by weight; the adhesive is 1-6% of the content of the pellet preparation in percentage by weight. The sustained-release pellet prepared by a preparation method of the mushroom extract sustained-release pellet can regulate immunity; the area of the sustained-release pellet on the surface of an absorption organ is increased, so that the bioavailability is improved, and the local irritation is little or removed.

Description

technical field [0001] The invention relates to a mushroom extract sustained-release pellet and a preparation method thereof. Background technique [0002] Shiitake mushrooms can increase energy, treat colds and remove intestinal parasites. The key ingredient of shiitake mushrooms is Xianggu polysaccharide. The products of shiitake mushroom extract are well recognized by consumers. These products are basically ordinary tablets and capsules. However, the above-mentioned dosage forms have a long disintegration time and disintegrate at a certain point in the body, which has a certain effect on the gastric mucosa. Irritation, low bioavailability point and other shortcomings, based on the above problems, we quickly introduced the pellet technology in the field of medicine to the field of food. Therefore, it is necessary to provide a new technical solution to solve the above problems. Contents of the invention [0003] The purpose of the present invention is to provide a susta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61K9/16A61K47/38A61P33/00A61P1/00A61P11/00A61P31/00
Inventor 不公告发明人
Owner QINGDAO AGRI UNIV
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