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Sea buckthorn extract pellet and preparation method thereof

A technology of extract and sea buckthorn, applied in the field of medicine and food, can solve the problems of long disintegration time, low bioavailability, irritation of gastric mucosa, etc., and achieve the effect of good effectiveness, high bioavailability and reduction of total dose

Inactive Publication Date: 2009-06-03
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are not many seabuckthorn extract products on the market, but they are all ordinary tablets and capsules. The above-mentioned dosage forms have a long disintegration time and disintegrate at a certain point in the body, which is irritating to the gastric mucosa and biological Disadvantages such as low utilization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take the following ingredients for the recipe

[0034] Sea Buckthorn Extract 8g microcrystalline cellulose 89g Hydroxypropylmethylcellulose 3g

[0035] Prepare pellet formulations as follows:

[0036] (1) Add the seabuckthorn extract of the above formula amount to microcrystalline cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0037] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0038] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0040] Take the following ingredients for the recipe

[0041] Sea Buckthorn Extract 40g sucrose 56g Polyvinylpyrrolidone 4g

[0042] Prepare pellet formulations as follows:

[0043] (1) Take the seabuckthorn extract of the above-mentioned formula amount and add sucrose, pulverize it to a micronized level with a ball mill, and mix well;

[0044] (2) polyvinylpyrrolidone is dissolved in water;

[0045] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0047] Take the following ingredients for the recipe

[0048] Sea Buckthorn Extract 60g sucrose 25g starch 11g Polyvinylpyrrolidone 4g

[0049] Prepare pellet formulations as follows:

[0050] (1) Take the seabuckthorn extract of the above-mentioned formula amount, add sucrose and starch, pulverize it to a micronized level with a ball mill, and mix well;

[0051] (2) polyvinylpyrrolidone is dissolved in water;

[0052] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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PUM

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Abstract

The invention provides a sea buckthorn extract pellet preparation composed of sea buckthorn and medical supplementary materials. The sea buckthorn extract pellet preparation is characterized in that the medical supplementary materials are excipients and binders; and in the pellet preparation, the content of sea buckthorn extract 2-75 percent by weight, the content of excipients is 20-97 percent by weight, and the content of binders is 1-5 percent by weight. The pellet preparation has high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy for operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of seabuckthorn extract and a preparation method thereof. Background technique: [0002] Seabuckthorn is the fruit of Hippophae fhamnoides L. Seabuckthorn is a traditional medicine of Tibetan medicine and Mongolian medicine in my country. It is a collection of "Pharmacopoeia of the People's Republic of China". It is one of the oldest plants on the earth and is recognized as the most precious edible and medicinal plant in the world. Modern research shows that seabuckthorn is rich in vitamins C, E, A, P, carotene, catechin, coumarin, phytosterols, flavonoids, fatty acids (unsaturated), organic acids and essential amino acids for humans and nearly 20 kinds of trace elements. Seabuckthorn fruit contains more than 200 kinds of biochemical components necessary for human body, multivitamins, carotenoids, phospholipids, flavonoids, phenolic compounds, unsaturat...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/16A61P1/16A61P3/06A61P9/10A61P9/12A61P37/02A61K131/00
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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