Sea buckthorn extract pellet and preparation method thereof

A technology of extract and sea buckthorn, applied in the field of medicine and food, can solve the problems of long disintegration time, low bioavailability, irritation of gastric mucosa, etc., and achieve the effect of good effectiveness, high bioavailability and reduction of total dose

Inactive Publication Date: 2009-06-03
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are not many seabuckthorn extract products on the market, but they are all ordinary tablets and capsules. The above-mentioned dosage forms have a

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0032] Example 1

[0033] Take the ingredients of the following formula for use

[0034] Sea buckthorn extract 8g Microcrystalline cellulose 89g Hydroxypropylmethylcellulose 3g

[0035] Prepare the pellet preparation according to the following method:

[0036] (1) Take the seabuckthorn extract of the above formula and add it to microcrystalline cellulose, pulverize it to the micronization level with a ball mill, and mix;

[0037] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;

[0038] (3) Pellets are made by extrusion-spheronization method.

Example Embodiment

[0039] Example 2

[0040] Take the ingredients of the following formula for use

[0041] Sea buckthorn extract 40g sucrose 56g Polyvinylpyrrolidone 4g

[0042] Prepare the pellet preparation according to the following method:

[0043] (1) Take the sea buckthorn extract of the above formula and add sucrose, pulverize it to the micronization level with a ball mill, and mix;

[0044] (2) Dissolve polyvinylpyrrolidone in water;

[0045] (3) Pellets are made by the pan-pill method.

Example Embodiment

[0046] Example 3

[0047] Take the ingredients of the following formula for use

[0048] Sea buckthorn extract 60g sucrose 25g starch 11g Polyvinylpyrrolidone 4g

[0049] Prepare the pellet preparation according to the following method:

[0050] (1) Take the sea buckthorn extract of the above formula and add sucrose and starch, pulverize it to the micronized level with a ball mill, and mix;

[0051] (2) Dissolve polyvinylpyrrolidone in water;

[0052] (3) Using centrifugal-fluidized pelletizing method to make pellets.

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PUM

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Abstract

The invention provides a sea buckthorn extract pellet preparation composed of sea buckthorn and medical supplementary materials. The sea buckthorn extract pellet preparation is characterized in that the medical supplementary materials are excipients and binders; and in the pellet preparation, the content of sea buckthorn extract 2-75 percent by weight, the content of excipients is 20-97 percent by weight, and the content of binders is 1-5 percent by weight. The pellet preparation has high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy for operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of seabuckthorn extract and a preparation method thereof. Background technique: [0002] Seabuckthorn is the fruit of Hippophae fhamnoides L. Seabuckthorn is a traditional medicine of Tibetan medicine and Mongolian medicine in my country. It is a collection of "Pharmacopoeia of the People's Republic of China". It is one of the oldest plants on the earth and is recognized as the most precious edible and medicinal plant in the world. Modern research shows that seabuckthorn is rich in vitamins C, E, A, P, carotene, catechin, coumarin, phytosterols, flavonoids, fatty acids (unsaturated), organic acids and essential amino acids for humans and nearly 20 kinds of trace elements. Seabuckthorn fruit contains more than 200 kinds of biochemical components necessary for human body, multivitamins, carotenoids, phospholipids, flavonoids, phenolic compounds, unsaturat...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/16A61P1/16A61P3/06A61P9/10A61P9/12A61P37/02A61K131/00
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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