51results about How to "Controlled release" patented technology

The invention relates to a preparation of oxidation resistant gelatin film containing tea polyphenol-chitosan nano granule, pertains to the field of applying chitosan controlled release and oxidation resistance in the gelatin film. The oxidation resistant gelatin film component comprises tea polyphenol-chitosan nano granules, gelatin and glycerin. The preparation includes dissolving gelatin and glycerin into deionized water in proportion to produce a gelatin solution, charging a predetermined amount of tea polyphenol-chitosan nano granule suspension, mixing uniformly, hypersonic de-gassing, removing dried film spreading on the organic glass board. The prepared nano tea polyphenol-chitosan gelatin film has oxidation resistance greatly improved comparing with the simple gelatin film phase, and oxidation resistance of the gelatin film is capable of lasting for longer time due to protection function of the chitosan to the tea polyphenol and slowly-releasing of the tea polyphenol. The oxidation resistant gelatin film can be biologically degraded, without environment pollution during application process; is capable of having functions of preventing loss of flavor substance in the food, preventing food oxidation, so as to reach the effect of anti-staling and prolonging storage period.

The invention discloses a plant antibacterial component based slow-releasing antibacterial fresh-keeping carton and a production method thereof and relates to the field of fresh keeping of agricultural products. The slow-releasing antibacterial fresh-keeping carton comprises a corrugated board and an antibacterial coating which coats the corrugated board, and the antibacterial coating is prepared from, by weight, 0.2-3% of clove extract, 0.4-4% of thymus serpyllum extract, 0.3-3% of lemon grass extract, 0.3-2% of prickly ash extract, 6-16% of moisture sensitive resin, 2-6% of beta-cyclodextrin, 0.02-2% of emulgator and 80-90% of distilled water. The production method includes: firstly, proportionally mixing all the components of the antibacterial coating with heating and stirring to produce a slow-releasing antibacterial coating solution; secondly, coating the corrugated board with the slow-releasing antibacterial coating solution to obtain the slow-releasing antibacterial corrugated board; finally, subjecting the antibacterial corrugated board to die cutting and creasing to produce the slow-releasing antibacterial fresh-keeping carton. The slow-releasing antibacterial fresh-keeping carton is applicable to fresh keeping of the agricultural products such as fruits and vegetables, and storage period of the fruits and vegetables can be prolonged by three to eight times.

The invention belongs to the technical field of preparation of biomedical high molecular polymer materials and discloses a cholesterol modified amphiphilic pH response pennicuius copolymer and a preparation method and a micelle system prepared based thereof. The copolymer has a structure shown in the formula I in the specification, wherein x is 10-36, y is 15-40 and z is 8-30. The copolymer is obtained by virtue of irregular copolymerization of a hydrophilic block hydroxyethyl methylacrylate, hydrophobic cholesterol and pH response block methacrylic acid N, N-diethyl aminoethyl combined with hydrophilic poly(ethylene glycol) methyl ether methacrylate. The copolymer is dissolved in a solvent to obtain a nanoscale micelle system, wherein the inner layer is a cholesterol modified hydrophobic chain segment, the middle layer is a pH response chain segment and the shell is a hydrophilic chain segment, so that the function of high entrapment performance, stable existence of a neutral condition and quick release in a weak acidic condition is achieved. By adjusting the proportions of the blocks in the polymer, the release rates of medicines can be regulated to satisfy the release requirements on different drugs.

The invention discloses a silver-containing nickel-based lubricating material with a surface micropore hard template, which uses nickel alloy as a substrate and contains a silver lubricating phase; and the surface of the material is provided with the micropore hard template capable of controlling the release of a lubricating agent and improving the hardness and abrasion resistance. A method for preparing the silver-containing nickel-based lubricating material with the surface micropore hard template comprises the following steps: firstly, mixing metal powder in a ball mill; secondly, compacting the mixed powder in a steel die, and then putting the compacted powder into a graphite die to carry out vacuum hot-pressing and molding; thirdly, finely grinding and polishing the hot-pressed material, and then putting the material into a metallic cementation furnace to carry out molybdenum cementation treatment; fourthly, putting the material subjected to the molybdenum cementation treatment into a nitriding furnace to carry out nitriding; and finally, etching micropores on the surface of the material subjected to the nitriding treatment by using pulse laser. The material limits sliver dispersing to the surface through the hard template, and uses micropores as a silver dispersing passage so as to control the release of the lubricating agent and improve the hardness and abrasion resistance; and the preparation method is simple and practical.

The invention relates to a multi-application safety management system based on an intelligent POS (Point of Sale) terminal and a method thereof. The system comprises an intelligent POS application platform (100) which is provided with an application management module (101) and an application signature module (102), and an intelligent POS terminal (200) which is provided with a hardware safety module (201) and a safety authentication module (202), wherein the hardware safety module (201) is used for at least pre-saving a root certificate public key file and an operator certificate public key file; the safety authentication module (202) is used for performing safety authentication on a signed application by using the operator certificate public key file saved in the hardware safety module when the signed application is downloaded into the intelligent POS terminal; and the operator certificate public key file is signed by a root certificate private key file. The multi-application safety management method is safe, reliable and extendible.

The invention discloses a method of preparing a controlled-release antibacterial film and an implant material by using an antibacterial composition. The method comprises the following steps of: injecting the antibacterial composition into an injector and installing a stainless steel needle head; coating a to-be-coated implant material by adopting a high-voltage power supply with voltage of 10 KV-30 KV at liquor flow velocity of 1 mL/h-5 mL/h and receiving distance of 5 cm-25 cm; finally, drying the coated implant material in vacuum under the room temperature for 24 hours-48 hours to obtain the controlled-release antibacterial film coated on the implant material, wherein the antibacterial composition comprises: first-class macromolecules selected from polylactic acid, polycaprolactone, polylactic acid-hydroxyacetic acid copolymer and polycaprolactone-hydroxyacetic acid copolymer, second-class macromolecules selected from polylactic acid-polyethylene glycol segmented copolymer, polycaprolactone-polyethylene glycol segmented copolymer, polyethylene oxide, polyvinyl alcohol, gelatin and hyaluronic acid, and an antibacterial agent. The controlled-release antibacterial film prepared by the method disclosed by the invention can realize controlled release of the antibacterial agent.

The invention belongs to the field of pharmacy and medical technology and relates to a dentoidin sponginum and a preparation method thereof. The sponginum provided by the invention comprises 80-99wt% of dentoidin and 1-20wt% of collage sponge matrix, wherein the dentoidin is fixed on the collagen sponge through crosslinking in different weight ratios. The sponginum provided by the invention ensures that the dentoidin is filled into ill parts with bone defects, nonunion of bone, bone tissue atrophy, bone fracture, poor bone healing and the like, so that the dentoidin plays roles in inducing bone formation, promoting bone repair and promoting wound convergence.

The invention provides novel non-sintered biological stuffing rapid in biofilm formation and a preparation method thereof, relating to biological stuffing and preparation methods thereof and solving the technical problems that the existing biological stuffing has long biofilm formation time and poor effluent quality in water treatment processes and preparation processes are high in energy consumption and pollute the environment. The biological stuffing is prepared from sepiolite, medical stone, cement, polyvinyl alcohol, sodium alginate, hydrogen peroxide, ferric chloride, manganese sulfate, cobalt chloride and agar. The method comprises the following steps: I. heating and dissolving polyvinyl alcohol and sodium alginate, adding hydrogen peroxide after cooling, and mixing the components uniformly, thus obtaining a liquid mixture; II. mixing the liquid mixture with other solid components, granulating the mixture, putting the granules at normal temperature, drying and sieving the granules, curing the granules at high pressure and low temperature, steam-curing the granules at constant temperature, and cooling the granules at normal temperature, thus obtaining the biological stuffing. Compared with the common ceramsite, the biological stuffing has short biofilm formation time, good effluent quality and coarse surface and is beneficial for microorganism growth. The biological stuffing is applied to the fields of environmental applied materials and sewage treatment.

The invention discloses a degradable bioactive screw and a manufacturing method thereof. The screw is composed of three parts including a tail part, a middle part and a head part, and the three partsare located on the same central axis; the tail part comprises a column body and a groove located in the end face of the column body; the middle part comprises a cylinder body connected with the columnbody, storage cavities located in the cylinder body, and a medicine distributed in the storage cavity, each storage cavity comprises a release layer and a channel connected with the release layer, threads are arranged on the surface of the cylinder body; and the head part comprises a circular truncated cone connected with the cylinder body and a hemisphere located on the end face of the circulartruncated cone. The method for manufacturing the degradable bioactive screw is convenient to operate and low in manufacturing cost, the screw in any shape and size can be manufactured according to needs, and meanwhile the screw has good biocompatibility and osteoinductivity.

The invention relates to an anti-explosion powder supplying device and pertains to the field of flow field testing. The anti-explosion powder supplying device has a cylinder body, the upper port of which is provided with an inner convex edge; an anti-explosion opening is arranged below the inner convex edge; the cylinder body between the inner convex edge and a gas-collecting skirt is provided with at least two ribs; the gas-collecting skirt is fixedly connected with one end of a feed pipe; the feed pipe is provided with a discharge pipe and the other end of the feed pipe is provided with an end cap; the lower port of the cylinder body is provided with an outer convex edge connected with a base; the bottom of the cylinder body is provided with an intake pipe; the intake pipe arranged in the cylinder body is provided with a fluidized pipe; and the top of the intake pipe is provided with a pipe plug. The device can provide required trace particles for a tested flow field evenly in time or put powder particles in a known space evenly, meet air-carrying particles with rather high pressure, ensure the safe running of the air-carrying particles, prevent the blocking of particles caused by cementation and solve the problem that the quality of powder supply is affected by the flowing out of particles in strands, thus improving the precision of the powder supply, being capable of controlling the flow speed and flow quantity of the particles evenly and effectively and ensuring the safe generation of powder supply.

The invention relates to the technical field of preparation of plant fresh-keeping agents, and provides a preparation method and application of inclusions of 1-methylcyclopropene and derivatives thereof. The inclusion agent for preparing the inclusion compound of the present invention is a cucurbituril mixture or any single component thereof. The 1-methylcyclopropene and its derivatives can exist stably after forming an inclusion complex with cucurbituril, thereby providing a convenient method for storing and transporting these compounds that can inhibit ethylene reaction of plants. At the same time, the preparation process of the inclusion complex is simple, the cost is low, and it is convenient to use. When in use, only need to put the inclusion complex directly into water or an aqueous solution containing acid or alkali to re-release 1-methylcyclopropene and its derivatives. thing.

The invention provides a cigarette functional filter stick with a perfuming carrier and a preparation method and application thereof, and belongs to the technical field of cigarette filter sticks, the cigarette functional filter stick with the perfuming carrier comprises tows and the perfuming carrier, the perfuming carrier adopts marine natural polysaccharide porous microspheres as a carrier for containing and adsorbing perfuming substances, and the perfuming carrier is a carrier for containing and adsorbing the perfuming substances. The perfuming carrier is uniformly sprayed on the tows, the perfuming carrier has a good slow-release effect and can meet the perfuming requirement, and the marine natural polysaccharide porous microspheres are high in release rate and good in release performance after perfuming and have the effects of being graceful in fragrance, stable in release and lasting in fragrance.

The invention relates to a saw horse carbonyl ruthenium compound which is a carboxylic acid group and an axial 2 electronic ligand through connecting a bridging on a double-ruthenium tetracarbonyl saw horse skeleton structure, the bridged carboxylic acid group is coordinated with metal ruthenium through O, the bond strength of Ru-Co is improved by utilizing center metal Ru (I) with low price, the saw horse carbonyl ruthenium compound has good stability under physiological conditions and is beneficial to target release, CO release is controllable, and the water solubility of molecular and the CO release speed can be improved by changing bridging carboxylic acid group R1CO2 and the axial 2 electronic ligand, so that the saw horse carbonyl ruthenium compound can be functionalized efficiently and is easy to derive. The synthetic process is simpler and easy to obtain, and an efficient functionalization method for saw horse carbonyl ruthenium is provided.

The invention discloses a preparing method for modified starch with a function of efficiently adsorbing and controllably releasing ethylene. The preparing method includes the steps that starch is blended into starch paste liquid with an ethyl alcohol aqueous solution, a NaOH solution is dropwise added, and the mixture reacts for 10 min to 120 min under the condition of 25 DEG C to 50 DEG C; centrifuging is conducted, neutralization is conducted with a hydrochloric-acid ethyl alcohol solution, and washing and drying are conducted; the dried starch is put into a 45-100% ethyl alcohol aqueous solution and put into a water bath of 30 DEG C to 70 DEG C for heating, washing and drying are conducted, and then the modified starch is obtained. Through testing, the content of ethylene in an ethylenecompound prepared with the modified starch is 49.6%(w/w), and the ethylene can be continuously released for 200 hours at the temperature of 4 DEG C, and can be continuously released for 100 hours atthe temperature of 25 DEG C. According to the preparing method, the starch modification and ethylene adsorption technology is simple, efficient and low in cost, and the product has broad application prospects in the field of air conditioning and fresh keeping of fruits and vegetables.

The invention relates to a cysteine/ferroferric oxide/copper sulfide/BSA (bovine serum albumin) nano-composite particle as well as preparation and application thereof. The nano-composite particle is degraded by utilizing ultrasonic waves with comparatively high power on a water/oil mixed solution interface to form microemulsion; Fe3O4 modified by cysteine is combined with BSA by a disulfide bond to form a shell; CuS is adsorbed on the BSA by electrostatic interaction; a comparatively large internal space is used for loading hydrophobic drug PTX (paclitaxel, dissolved in polyoxyethylated castor oil) insoluble in water. Compared with the prior art, the nano-composite particle has wide application prospect in the aspects of nuclear magnetic imaging, targeted drug delivery, photothermal therapy, therapy combined with chemotherapy and the like, an anti-cancer drug and a photothermal reagent can be transmitted to cancer positions, the toxic and side effects on normal tissues and cells are reduced, meanwhile, cancer cells are effectively killed, so that the treatment effect is further improved; a preparation method is simpler (a one-step microemulsion method is adopted) and has the advantage of large-scale production.

The invention relates to a nanometer probe for detecting activity of intracellular telomerase in situ and a preparation method thereof. The prepared nanometer probe employs multihole silicon nanoparticle (MSN) as a carrier, the pore channel of the nanoparticle is covalently fixedly provided with a fluorescence quencher BHQ and is filled with fluorescein, and the surface of the nanoparticle is wrapped with DNA chain O1 of telomerase substrate fragment (TP) through electrostatic adsorption, so that fluorescein is plugged in the pore channel. BHQ quenches fluorescence of fluorescein, and the fluorescence state of the nanometer probe is off. Under the effect of telomerase, the 3' end of O1 on the surface of the probe is extended, and a plurality of TTAGGG fragments complementing 5' end are generated, so that the two ends hybridize and a cyclic structure is formed and breaks away from the probe surface, and thus the pore channel is opened and fluorescein in the probe is released, and the fluorescence state is transferred into open. The probe and cells are incubated, the probe enters cytoplasm, the probe pore channel is opened under the effect of telomerase in cytoplasm, and fluorescence generated by released fluorescein is utilized to realize in-situ detection on activity of intracellular telomerase.

The invention relates to a nano-silver anti-infection hernia repair patch. The nano-silver anti-infection hernia repair patch comprises a hernia repair patch base material, wherein nano-silver stabilized by a high-molecular polymer is immobilized on the surface of the hernia repair patch base material. The hernia repair patch disclosed by the invention is excellent in antibacterial performance and spectrum antibacterial performance, and free from medicine resistance. By using the hernia repair patch disclosed by the invention for treating hernia, antibiotics do not need to be used for the whole body of the patient to prevent infection.

The invention discloses a method for preparing a zinc oxide-doped titanium dioxide nanotube on a pure titanium surface, and belongs to the technical field of material surface modification. The method comprises the following steps: a pretreated pure titanium sample is put on a sample table of magnetron sputtering equipment, and a titanium zinc alloy target is placed opposite to the sample; after the vacuumizing is performed, argon is fed in a vacuum chamber, certain voltage is applied to the alloy target and the sample, and titanium and zinc elements are deposited on the pure titanium surface to form a titanium zinc composite film layer under the effect of plasma bombardment; and then, the anodic oxidation treatment is performed for the composite film layer to prepare the zinc oxide-doped titanium dioxide nanotube. The nanotube, prepared by the method, has excellent infection resistance and osseointegration capacity.

The invention discloses an ethylene gas embedding material with slow release performance and an embedding method. The embedding method comprises the steps: putting cucurbituril into a high-pressure reaction kettle, wherein the adding amount of the cucurbituril is 10% to 40% of the volume of the reaction kettle; vacuumizing the reaction kettle; introducing ethylene gas, wherein pressure intensity is controlled as 0.1 to 2.0Mpa; reacting for 8 to 48h under 15 to 35 DEG C; opening an air outlet valve of the reaction kettle after reaction finishes and absorbing unabsorbed ethylene to obtain an ethylene embedding product with the slow release performance. Tests show that the content of ethylene in the obtained product can reach 9.3% (w/w) or more, and the ethylene can be continuously released for 720h under 25 DEG C. To an ethylene adsorption technology, the method has the advantages of simpleness, high efficiency and low cost; composite can exist stably; the product has a wide applicationprospect in the field of controlled-atmosphere refreshment of fruits and vegetables.

The invention discloses a delivery and release device of an aortic stent; the delivery and release device comprises a sheath core assembly, an outer sheath tube and a control handle for controlling the axial movement of the sheath core assembly and the outer sheath tube; the control handle comprises a support main body, a fixed handle and a sliding handle movably sleeving the support main body, and the outer sheath tube is connected with the sliding handle; the sheath core assembly is connected with the support main body; the sliding handle slides axially and performs circumferential rotary cooperation relative to the support main body; according to the axial position of the sliding handle, the sliding handle and the fixed handle are in axial attachment and separation states; the sliding handle and the fixed handle are in rotary cooperation in a liner contact mode in an attachment state. The liner contact mode is adopted between the fixed handle and the sliding handle, so the resistance is reduced, the smoothness and the hand feeling of the operation are improved, and the risk of part disintegration is avoided.

The invention relates to a grape fresh powder and a preparation method thereof, wherein the grape fresh powder comprises insecticides and heat-seal package papers, the insecticides are quantificationally heat-sealed in a medicine package which is made from package papers, and comprise pyrosulfite, controlled-release agents and filling agents, the heat-seal package papers are perforated through a laser perforating machine, holes are similar elliptical holes, the areas of the holes are 2-12*10-3mm2, and the density of the holes is 2-5/cm2. The grape fresh powder and the preparation method thereof are simple in process, high in production efficiency, steady and controlled in quality, and the slow release period of sulfur dioxide is 3-5 months.

The invention relates to an ultrasonic controlled release prostate dilatation drug-delivery balloon system. The system comprises a balloon catheter, a dilatation balloon and an ultrasound probe. The dilatation balloon catheter has a four-chamber structure, and three chambers are used for balloon filling and the other chamber for drainage of urine. The compliant balloons at both ends are located atthe lower end of the bladder and urethra to secure the dilatation balloon system and reduce damage from displacement and friction. The drug-loaded balloon is used for dilatation of the narrow urethra, and the surface is designed with a spiral shape, a zigzag shape, a wave shape, and the like, and a specific surface area is increased to increase the drug loading. Drug loading can be realized through the microcapsules with different particle sizes, microcapsules can be stimulated by ultrasound with a certain intensity and frequency to release into the urethra mucosa and prostate to treat urethral stricture caused by prostatic hyperplasia. The small ultrasound probe can be used in vitro or in the rectum. The real-time contrast during the catheterization process accurately identifies the urethral stricture, so that the dilatation process is more intuitive and accurate. The ultrasonic probe can also control the intensity, frequency and time of the ultrasonic wave in real time, so that thedrug-loaded microcapsules on the surface of the dilatation drug-delivery balloon can be released at the target position, and the drug utilization rate and therapeutic effect are obtained.

The invention provides a pramipexole dihydrochloride sustained-release tablet composition and a preparation method thereof. The composition comprises the following components by weight: 0.1%-1% of pramipexole dihydrochloride, 10%-40% of hydroxypropyl methyl cellulose, 25%-50% of polyacrylic acid resin, 20-60% of pregelatinized starch, 0.3%-1.5% of colloidal silicon dioxide and 0.5%-1% of magnesium stearate.

The invention discloses a composite drug intravascular stent which comprises a bare metal stent (prepared from a nickel-titanium memory alloy material), recombinant human collagen and folic acid are loaded on a stent body, HMGB1 fragment peptide and a VEGFR-2 antibody are crosslinked on the surface of the bare metal stent. Specifically, a dynamic liquid electrospinning technology is utilized to load a composite spinning solution of recombinant human collagen, folic acid, HMGBI fragment peptide and the VEGFR-2 antibody onto a nickel-titanium memory alloy bare metal stent to form an intravascular stent loaded with the recombinant human collagen and folic acid and cross-linked with the HMGBI fragment peptide and the VEGFR-2 antibody, so that EPCs capture, homing, proliferation and differentiation are promoted, and rapid endothelialization of the blood vessel is realized. The stent not only can be used for coronary stents, but also can be used for cerebrovascular stents, renal artery stents, main artery stents and the like.

The invention relates to the technical field of high polymer materials, in particular to a nano container and a sol-gel coating based on a ZIF-8 structure and a preparation method of the nano container and the sol-gel coating. According to the invention, ZIF-8 nano-particles are used as a self-sacrifice template of HMSN, a pH response type'gate valve 'and an interface compatibility auxiliary agent, and a novel pH response type HMSN-BTA-ZIF-8 nano-container is designed. The HMSN-BTA-coated ZIF-8 is used as a substrate to prepare a sol-gel coating, and then the sol-gel coating is applied, so that metal corrosion can be effectively delayed. The obtained sol-gel coating (intelligent anticorrosive coating) has a potential self-healing effect, and compared with a traditional metal anticorrosive agent, the sol-gel coating is low in toxicity, small in pollution in the production process and environmentally friendly.

The invention discloses a real-time hypertension diagnosis and treatment integrated system capable of realizing controllable medicine release, and particularly relates to the technical field of medicine. The system comprises a wearable blood pressure monitoring device and a microneedle type controllable administration device, wherein the wearable blood pressure monitoring device comprises a bracelet worn at a wrist part, and the microneedle type controllable administration device comprises an arm band worn at an arm part. The system detects weak pressure produced pulse by use of high sensitivity of a graphene sensor to monitor blood pressure in real time, controllable release of antihypertensive medicine molecules is realized by photosensitive lipidosome nanoparticles, the blood pressure monitoring device and the microneedle medicine release device are organically combined together to form a diagnosis and treatment system by a wireless transmission technology, and the system immediately calculates required dosages and accurately releases corresponding dosages by controlling illumination time and intensity to realize real-time and accurate regulation of blood pressure when detectingabnormality of blood pressure.

The invention provides a fucoxanthin composite nanofiber and a preparation method thereof. The preparation method comprises the following steps that S1, fucoxanthin and cyclodextrin are correspondingly dissolved in an edible polar organic solvent to prepare a fucoxanthin mixed dispersion system; step 2, polyvinylpyrrolidone is added into the fucoxanthin mixed dispersion system to obtain a spinning solution, and defoaming is carried out; and step 3, wet electrospinning is carried out by using an electrostatic spinning process, and the fucoxanthin composite nanofiber is collected. The fucoxanthin composite nanofiber changes the limitation that fucoxanthin is insoluble in water while retaining the activity of fucoxanthin, and the thermal stability of fucoxanthin is improved; according to the preparation method, edible solvents are adopted in fiber preparation, any other harmful solvents and diluents are not used, and the method is easy to collect and use and environmentally friendly; and the whole preparation process is simple in technology, low in device requirement, low in energy consumption in the process and low in cost, and can be widely applied to rapid dissolution of fucoxanthin or large-scale application in food industry.

The invention discloses a preparation method of microspheres capable of increasing entrapment efficiency of hydrophilic medicines. The preparation method comprises the following steps: step (a): preparing an inner water phase containing hydrophilic medicines, and an oil phase containing polymer carriers; step (b): mixing the inner water phase with the oil phase to obtain primary emulsion, and after formation of the primary emulsion, performing fast temperature reduction to increase stickiness of primary emulsion to 1000-2000cp; step (c): mixing and dispersing the primary emulsion after stickiness increase in the step (b) in a volume ratio being (1:100)-(1:200) in an outer water phase to obtain secondary emulsion, and immediately maintaining the formed secondary emulsion static for 5-10minso as to obtain primary products; and step (d): performing first-round drying on the primary products to obtain humid microspheres, wherein the residual quantity of organic solvents in the obtained humid microspheres is not higher than 0.5%, and then performing second-round drying to remove moisture and remaining solvents so as to obtain microsphere end products. Through the adoption of the preparation method, the polypeptide microspheres high in entrapment efficiency, high in medicine loading quantity and low in grain size can be obtained.

The invention discloses a preparation method of an emergency survival hemostatic based on natural zeolite in Jinyun of Zhejiang. The emergency survival hemostatic takes natural clinoptilolite and natural mordenite in Jinyun of Zhejiang Province as raw materials and comprises main components of monox, titanium oxide, alumina, ferric oxide, magnesia, calcium oxide, sodium oxide, potassium oxide and the like. The emergency survival hemostatic can be used for different medical occasions to stanch bleeding, can be used for preparing band aids, transfusion plasters, self-adhesion dressing, first-aid packets and the like by being mechanically combined with other medical materials and medical instruments. Meanwhile, bacteriophage, anodyne and the like can be adsorbed in the emergency survival hemostatic by using the ion exchange characteristic of the emergency survival hemostatic; the emergency survival hemostatic can be used as a medical transmission carrier; and other ions can be loaded by using the ion exchange characteristic of the emergency survival hemostatic, thereby better curative effect can be obtained. The emergency survival hemostatic based on natural zeolite in Jinyun of Zhejiang has the advantages of high stanching speed, low heat release, asepsis, apyrogeneity, non-cytotoxicity, no sensitivity response, harmlessness to skin, no reducing substances, no acid-base excitability and low cost, can extract content heavy metal with extremely-low content and is convenient for use.

The invention discloses a preparation method of a microbubble ultrasound contrast agent containing mitomycin C. The preparation method is characterized in that a phospholipid complex is prepared by use of the phospholipid and the mitomycin C so that the fat solubility of the mitomycin is greatly improved, and then the phospholipid complex is prepared into a lipidosome so that the encapsulation efficiency and the drug-loading capacity of the mitomycin C lipidosome are improved. The obtained lipidosome is freeze-dried by use of a freeze-drying protecting agent and filled with a gas to obtain the microbubble ultrasound contrast agent containing the mitomycin C. Before use, normal saline is added to the microbubble ultrasound contrast agent by a demand quantity, and then the microbubble ultrasound contrast agent can be used after being oscillated and hydrated. The obtained drug-loading ultrasonic microbubbles are capable of realizing real-time detection and diagnosis on the generation and development of tumors and curative effects by virtue of ultrasonic imaging; and besides, the purpose of controlled targeted drug release can be achieved by virtue of passive targeting of microbubbles and by releasing the drug by ultrasonically crushing the microbubbles. As a result, the microbubble ultrasound contrast agent has great significance for preventing, diagnosing and treating tumors.