Raw ginger micro-pill and preparation method thereof
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A technology of pellets and ginger, applied in the field of medicine and food, to achieve the effect of rapid onset and high bioavailability
Inactive Publication Date: 2016-03-30
JF PHARMALAND TECH DEV
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Problems solved by technology
[0002] At present, ginger products are widely recognized by consumers, and they are basically ordinary tablets and capsules, but the disintegration time of the above dosage forms is long; A certain part of the body disintegrates, which is irritating to the gastric mucosa; low bioavailability and other disadvantages
Method used
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Embodiment 1
[0028] Take the following ingredients for the recipe
[0029] Ginger Extract 10g
[0030] Microcrystalline cellulose 82g
[0031] Hydroxypropyl Methyl Cellulose 4g
[0032] Prepare pellet formulations as follows:
[0033] (1) Take the ginger in the above formula, add microcrystalline cellulose, pulverize it to a micronized level with a ball mill, and mix well;
[0034] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;
[0035] (3) Micro-pills are made by extrusion-spheronization into pellets.
Embodiment 2
[0037] Take the following ingredients for the recipe
[0038] Ginger Extract 15g
[0039] Starch 85g
[0040] Polyvinylpyrrolidone 5g
[0041] Prepare pellet formulations as follows:
[0042] (1) Take the ginger in the above formula, add starch, pulverize it to a micronized level with a ball mill, and mix well;
[0043] (2) Dissolve the adhesive polyvinylpyrrolidone in water;
[0044] (3) Micro-pills are made by pan-pill method.
Embodiment 3
[0046] Take the following ingredients for the recipe
[0047] Ginger Extract 8g
[0048] Sucrose 49g
[0049] Starch 34g
[0050] Polyvinylpyrrolidone 4g
[0051] Prepare pellet formulations as follows:
[0052] (1) Take the ginger in the above formula, add sucrose and starch, grind it to a micronized level with a ball mill, and mix well;
[0053] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;
[0054] (3) Using the centrifugal-fluidized pelleting method to make pellets.
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Abstract
The invention provides a raw ginger micro-pill preparation prepared from raw ginger and medicinal auxiliary materials, and is characterized in that the medicinal auxiliary materials comprise an excipient and an adhesive; in the micro-pill preparation, the weight percentage of the raw ginger is 5-30%, the weight percentage of the excipient is 75-90%, and the weight percentage of the adhesive is 1-5%. The micro-pill preparation has the advantages of high dissolution rate and high bioavailability; and a preparing method is simple, convenient, and easy to operate.
Description
[0001] Technical field: [0002] The invention relates to the technical field of medicine and food, in particular to ginger pellets and a preparation method thereof. [0003] Background technique: [0004] At present, ginger products are well received by consumers, and they are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; disintegrating at a certain point in the body has a certain effect on the gastric mucosa. Irritation; low bioavailability and other disadvantages. Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable release in the body and high bioavailability, so as to better meet the needs of the general public. consumer needs. [0005] Pharmaceutical excipients such as excipients, binders, porogens, disintegrants, and plasticizers are generally adde...
Claims
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Application Information
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