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Beta-carotene pellet and method for preparing the same

A technology of β-carotene and carotene, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of gastric mucosal irritation, long disintegration time, and low bioavailability, and achieve effective Good sex, high bioavailability, and the effect of reducing the number of times of taking

Inactive Publication Date: 2008-07-16
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, products about β-carotene are favored by consumers. These products are basically ordinary tablets and capsules. The above-mentioned dosage forms have a long disintegration time; Gastric mucosa is irritating to a certain extent; low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take the following ingredients for the recipe

[0034] β-carotene

1.5g (based on pure product)

starch

94g

Hydroxypropylmethylcellulose

4.5g

[0035] Prepare pellet formulations as follows:

[0036] (1) Take the β-carotene of the above-mentioned formula amount and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0037] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0038] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0040] Take the following ingredients for the recipe

[0041] β-carotene

5g (based on pure product)

starch

90g

Polyvinylpyrrolidone

5g

[0042] Prepare pellet formulations as follows:

[0043] (1) Take the β-carotene of the above-mentioned formula amount and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0044] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0045] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0047] Take the following ingredients for the recipe

[0048] β-carotene

8g (based on pure product)

Crystalline Cellulose

88.5g

Hydroxypropylmethylcellulose

3.5g

[0049] Prepare pellet formulations as follows:

[0050] (1) Take the β-carotene of the above-mentioned formula amount and add the crystal cellulose, pulverize it to a micronization level with a ball mill, and mix well;

[0051] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;

[0052] (3) The pellets are made by the centrifugal-fluidized pelletizing method.

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Abstract

The invention provides a beta-carotene micro-pill prepared from beta-carotene and medicinal adjuvant, characterized in that the medicinal adjuvant comprises an excipient and a bonding agent; the content of the beta-carotene in the beta-carotene micro-pill is 1-10 weight percent, the excipient 70-95 weight percent and the bonding agent 1-5 weight percent. The beta-carotene micro-pill of the invention has the advantages of high dissolution rate, high bioavailability, easy preparation method and convenient and easy operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of beta-carotene and a preparation method thereof. Background technique: [0002] Beta-carotene, whose name comes from the Latin carrot, is a member of the family of natural chemicals such as carotene or carotenoids. It is found in abundance in plants, giving fruits and vegetables their rich yellow and orange hues. Like other carotenoids, beta-carotene is an antioxidant. Consuming foods rich in beta-carotene protects the body from damaging molecules called free radicals. Through a process of oxidation, free radicals damage cells. If things go on like this, it may cause the human body to suffer from various chronic diseases. Some studies suggest that getting enough beta-carotene in your diet may reduce your risk of two chronic diseases -- heart disease and cancer. In addition, β-carotene also has the functions of preventing dry and rough skin; helping...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/015A61K9/20A61K47/32A61K47/38A61P39/06
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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