Levorotation carnitine pellet and method for preparing the same

A technology of L-carnitine and pellets, which is applied in the field of medicine and food, can solve the problems of low bioavailability, long disintegration time, irritation of gastric mucosa, etc., achieve high bioavailability, good effectiveness, and reduce the number of times of taking Effect

Inactive Publication Date: 2008-07-16
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The products currently developed are basically ordinary tablets and capsules, but the above-mentioned dosage forms have disadvantages such as long disintegration time; disintegration at a certain point in the body, which is irritating to the gastric mucosa; low bioavailability, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take the following ingredients for the recipe

[0032] L-carnitine

30g

starch

67g

Hydroxypropylmethylcellulose

3g

[0033] Prepare pellet formulations as follows:

[0034] (1) Add the L-carnitine of the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0035] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0036] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0038] Take the following ingredients for the recipe

[0039] L-carnitine

50g

starch

46g

Polyvinylpyrrolidone

4g

[0040] Prepare pellet formulations as follows:

[0041] (1) Add the L-carnitine of the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0042](2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0043] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0045] Take the following ingredients for the recipe

[0046] L-carnitine

75g

Crystalline Cellulose

23g

Hydroxypropylmethylcellulose

2g

[0047] Prepare pellet formulations as follows:

[0048] (1) Take the L-carnitine of the above-mentioned formula amount and add the crystal cellulose, pulverize it to a micronization level with a ball mill, and mix well;

[0049] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;

[0050] (3) The pellets are made by the centrifugal-fluidized pelletizing method.

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Abstract

The invention provides a levocarnitine micro-pill which is prepared from levocarnitine and pharmaceutic adjuvant, characterized in that the pharmaceutic adjuvant is an excipient and a bonding agent; the content of the levocarnitine in the levocarnitine micro-pill is 10 to 90 weight percent; the excipient 20-80 weight percent and the bonding agent 1-5 weight percent. The levocarnitine micro-pill of the invention has the advantages of high dissolution rate, high bioavailability, easy preparation method and convenient and easy operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of L-carnitine and a preparation method thereof. Background technique: [0002] L-carnitine is an amino acid that promotes the conversion of fat into energy. No toxic side effects on the human body. Especially suitable for people to do aerobic exercise to reduce fat. The effect is more obvious. Different types of daily diets already contain 5-100 mg of L-carnitine. L-Carnitine is produced in the body's liver and kidneys and stored in the muscles, semen, brain and heart. L-Carnitine is indicated for a variety of problems related to heart health: preventing heart disease, improving heart function in people with congestive heart problems, minimizing its damage when following a heart attack, reducing angina pain, improving heart rhythm Uneven without affecting blood pressure, when increasing high-density cholesterol or good cholesterol, it reduces blood ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/205A61K9/20A61K47/38A61K47/32A61P1/14A61P3/04A61P3/06A61P3/10A61P7/08A61P9/10A61P15/08A61P25/08A61P25/24A61P25/28A61P31/18A61P37/06
Inventor 李红艳
Owner JF PHARMALAND TECH DEV
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