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Soybean isoflavone micropills and preparation thereof

A technology of isoflavone pellets and soybean isoflavones, applied in the field of medicine and food, can solve the problems of long disintegration time, low bioavailability, gastric mucosal irritation, etc., and achieves good effectiveness, high bioavailability, and reduced dosage. effect of times

Inactive Publication Date: 2008-07-09
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, soybean isoflavone products are favored by consumers. These products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; The mucous membrane is irritating to a certain extent; the disadvantages such as low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Take the ingredients for the following recipe:

[0036] Soy Isoflavones

2g (based on pure product)

Methylcellulose

84g

Polyvinylpyrrolidone

2g

[0037] Prepare pellet formulations as follows:

[0038] (1) Add the soybean isoflavones of the above-mentioned formula amount to methyl cellulose, pulverize to the micronization level with a ball mill, and mix well;

[0039] (2) polyvinylpyrrolidone is dissolved in 65% ethanol solution;

[0040] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0042] Take the following ingredients for the recipe

[0043] Soy Isoflavones

12g (based on pure product)

sucrose

62g

starch

46g

[0044] Prepare pellet formulations as follows:

[0045] (1) Add the soybean isoflavones in the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0046] (2) With part of the sucrose as the core, the remaining part of the sucrose is made into syrup to play a binding role;

[0047] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0049] Take the following ingredients for the recipe

[0050] Soy Isoflavones

20g (based on pure product)

starch

75g

Hydroxypropylmethylcellulose

5g

[0051] Prepare pellet formulations as follows:

[0052] (1) Add the soybean isoflavones in the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0053] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of water;

[0054] (3) The pellets are made by the centrifugal-fluidized pelletizing method.

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PUM

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Abstract

The present invention provides a soybean isoflavone pellet preparation which is made from the soybean isoflavone and medical auxiliary materials and is characterized in that the medical auxiliary materials are excipient and bond. In the pellet preparation, the weight percentages of the materials are that: 1 percent to 50 percent of the soybean isoflavone, 55 percent to 98 percent of the excipient and 1 percent to 5 percent of the bond. The pellet preparation can be made into a slow-release or intestinal juice soluble preparation according to the requirement. The pellet preparation of the present invention has high leaching rate and high biological utilization degree, and the preparation method is simple and convenient and is easy for operating.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of soybean isoflavone and a preparation method thereof. Background technique: [0002] Soy isoflavones are a kind of phytoestrogens, which are extracted from soy plants such as soybeans and black beans. They are very beneficial to human health, especially closely related to the health of women throughout their lives. Long-term clinical experiments have proved that soybean isoflavones have weak estrogen-like effects on those with low estrogen levels, and can prevent and treat some diseases related to hormone level decline, such as menopausal syndrome, osteoporosis, and elevated blood lipids; For those with high estrogen levels, it shows anti-estrogen activity, can prevent breast cancer and endometritis, and has a two-way regulating balance function. [0003] At present, soybean isoflavone products are favored by consumers. These products are basically ord...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K9/20A61K9/22A61K47/32A61K47/38A61P15/00A61P15/12A61P19/10A61P35/00
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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