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Magnolia bark extract pellet and preparation method thereof

The technology of extract and Magnolia officinalis is applied in the field of pellets made from Magnolia officinalis extract and its preparation, which can solve the problems of low bioavailability, long disintegration time, irritation of gastric mucosa, etc. Reduce the number of times of taking, the effect of the release curve is obvious

Inactive Publication Date: 2012-05-23
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the products of magnolia bark extract are well recognized by consumers. These products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; Gastric mucosa is irritating to a certain extent; low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A kind of magnolia bark extract micropellet preparation, the pharmaceutical auxiliary materials are excipients and binders, wherein the weight percentage of magnolia bark extract in the micropill preparation is 10%, and the weight percentage of excipient is 85%, The percentage content of the binder is 5%, and a qualified pellet preparation is prepared.

Embodiment 2

[0047] A kind of magnolia bark extract micropellet preparation, the pharmaceutical auxiliary materials are excipients and binders, wherein the weight percentage of magnolia bark extract in the micropill preparation is 60%, and the weight percentage of excipient is 38%, The percentage of binder is 2%.

Embodiment 3

[0049] A kind of magnolia bark extract micropellet preparation, the pharmaceutical auxiliary materials are excipients and binders, wherein the weight percentage of magnolia bark extract in the micropill preparation is 20%, and the weight percentage of excipient is 76.5%, The percentage of binder is 3.5%.

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PUM

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Abstract

The invention provides a magnolia bark extract pellet preparation which is prepared from a magnolia bark extract and pharmaceutic adjuvants and is characterized in that the pharmaceutic adjuvants comprise an excipient and a binding agent; and the pellet preparation comprises 10-60wt% of the magnolia bark extract, 35-89wt% of the excipient and 1-5wt% of the binding agent. The pellet preparation can be prepared into a sustained-release preparation or an enteric preparation according to requirements. Pharmacology experiments show that the pellet provided by the invention has the effects of sterilizing, tranquilizing and allaying excitement and the like.

Description

technical field [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of magnolia bark extract and a preparation method thereof. Background technique [0002] Magnolia officinalis extract is the extract of the bark of Magnolia officinalis Rehd. et Wils. The main components are lignans, magnolol, honokiol, honokiol, etc., as well as monoterpene lignans, norlignans, dilignans Vegetarian compounds, volatile oils and other ingredients. It has antibacterial, sedative central nervous system, muscle relaxation and anti-ulcer effects. It is used to treat stroke, typhoid fever, cold and headache, qi stasis, blood stasis, food accumulation and qi stagnation, etc. [0003] At present, the products of magnolia bark extract are well recognized by consumers. These products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; Gastric mucosa has a certain degree of irritation...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/16A23L1/29A61P1/14A61P9/10A61P25/04A61P31/04A23L33/00
Inventor 王倩
Owner JF PHARMALAND TECH DEV
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