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Controlled degradation magnesium alloy coating bracket and preparation thereof

A magnesium alloy and coating technology, applied in metal material coating process, cleaning method using liquid, coating and other directions, can solve problems such as delaying the degradation of magnesium alloy materials, and achieve improved stability, delayed corrosion, and reduced degradation rate. Effect

Inactive Publication Date: 2008-07-09
LEPU MEDICAL TECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since there is no surface anti-corrosion treatment process for magnesium alloys, in the blood, polymer materials and magnesium alloys may start to degrade at the same time, so the surface of magnesium alloy materials must first be treated with anti-corrosion treatment to delay the degradation of magnesium alloy materials

Method used

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  • Controlled degradation magnesium alloy coating bracket and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] High-purity magnesium is selected and polished, and then laser-engraved into vascular stents;

[0065] ①Surface cleaning: cleaning the surface of the bracket body 101 with an ultrasonic frequency of 100khz, including: 1) cleaning with a medical ethanol solvent with a concentration of 75% for 5 minutes; 2) cleaning with an analytically pure acetone solution with a concentration of 99.5% for 5 minutes; 3 ) cleaning with deionized water for 5 minutes; placing the cleaned bracket body 101 in a vacuum dryer to dry;

[0066] ②Surface anticorrosion treatment: immerse the bracket body 101 in a solution of potassium dichromate 15g / L, nitric acid 15g / L, and sodium chloride 1.0g / L, and oxidize it at 80°C for 1 minute, and an oxide film can be formed on the surface;

[0067] ③ Preparation of degradable polymer film drug-loaded coating; put the antiseptic-treated stent 1 into 1.0 mg / mL polylactic acid (PLA) solution and soak for 15 minutes, and put it on Feige TGL-16G centrifuge at ...

Embodiment 2

[0070] AZ91B magnesium alloy is selected and polished, and then laser-engraved into vascular stents;

[0071] ①Surface cleaning: cleaning the surface of the bracket body 101 with an ultrasonic frequency of 28khz, including: 1) cleaning with a medical ethanol solvent with a concentration of 75% for 10 minutes; 2) cleaning with acetone analytically pure solution with a concentration of 99.5% for 10 minutes; 3 ) cleaning with deionized water for 10 minutes; placing the cleaned bracket body 101 in a vacuum dryer to dry;

[0072] ②Surface anticorrosion treatment: Anodize the cleaned stent body 101, and install the same stent body 101 on the two electrodes. The composition of the bath solution for anodic oxidation treatment is: potassium permanganate 15g / L, trisodium phosphate 15g / L, Potassium Fluoride 25g / L, Potassium Hydroxide 65g / L, Aluminum Hydroxide 15g / L, at 30°C, oxidize for 15 minutes, and the current density is 3A / dm 2 , the AC voltage is 60V, and an oxide film can be for...

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Abstract

The invention relates to a controlled degradation magnesium alloy coating stent and a preparation method. The stent body is made of medical high purity magnesium or magnesium alloy by mechanical processing or laser carving; the stent body is provided with a drug-loading coating which bears curative drug; the surface of the stent body is provided with an anti-corrosive coating; the surface of the anti-corrosive coating is provided with a degradable polymer film drug-loading coating; the preparation method includes surface cleaning, preparation of the degradable polymer film drug-loading coating, and application of curative drug; through (1)surface cleaning, (2)preparation of the degradable polymer film drug-loading coating, and (3)application of curative drug, an oxide film is formed on the surface; different drugs and dosage can be fixed by regulating the molecular weight and the thickness of the polymer layer, the drug-loading quantity is more than 30 percent, which improves the fixed stability of the drug, greatly reduces the degradation speed of the magnesium alloy and controls release of the drug, delays corrosion of the magnesium alloy, extends the service life of the stent, is safe in use, and meets the clinical requirement.

Description

technical field [0001] The invention belongs to the field of instruments applied in the human body, and relates to a controllable degradable magnesium alloy coating stent and a preparation method thereof. Background technique [0002] In 1976, German scholar Andrea Gronzgo first proposed the idea of ​​installing a stent in the artery. By the 1990s, coronary artery stents had been widely used in clinical treatment. At present, the coronary artery stent technology has been developed to a drug-eluting stent based on stainless steel and cobalt-chromium alloy, but it still cannot fundamentally solve the problem of thrombosis and restenosis in the stent, and there are high rates of restenosis after surgery and strong thrombosis And stents permanently remain in the body and other defects, the long-term effect is not ideal. [0003] Magnesium is one of the most abundant elements on the earth, and it is also the fourth most abundant cation in the human body and the second most abund...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/08A61L31/02A61L31/16A61L27/40A61L27/54A61L27/04A61L27/14A61F2/82C25D11/02C23C22/24B08B3/12C23G5/024C23G1/22
CPCA61L27/306A61L27/34A61L27/54A61L31/10A61L31/148A61L2300/606
Inventor 董飒英张正才蒲忠杰王建华王玲王小琴
Owner LEPU MEDICAL TECH (BEIJING) CO LTD
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