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Chondroitin sulfate pellet and preparation method thereof

A technology of chondroitin sulfate and cartilage sulfate, which is applied in food preparation, bone diseases, pharmaceutical formulations, etc., can solve the problems of long disintegration time, irritation of gastric mucosa, low bioavailability, etc., achieve good effectiveness and reduce dosage The effect of high frequency and bioavailability

Inactive Publication Date: 2010-05-12
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the chondroitin sulfate products in the market are biochemical products, which are favored by the majority of consumers. In addition to being used as a medicine, a large number of chondroitin sulfate is used as a supplement for improving joint diseases and as a health food application. It has been popular for many years. These products are basically ordinary tablets and capsules. However, the above-mentioned dosage forms have a long disintegration time and disintegrate at a certain point in the body. They are irritating to the gastric mucosa and have low bioavailability. and other shortcomings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take the following ingredients for the recipe

[0033] Chondroitin Sulfate

35g

starch

61g

Hydroxypropylmethylcellulose

4g

[0034] Prepare pellet formulations as follows:

[0035] (1) Add the chondroitin sulfate of the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0036] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0037] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0039] Take the following ingredients for the recipe

[0040] Chondroitin Sulfate

50g

sucrose

45g

Polyvinylpyrrolidone

5g

[0041] Prepare pellet formulations as follows:

[0042](1) Take the chondroitin sulfate of the above-mentioned formula amount and add sucrose, pulverize it to a micronized level with a ball mill, and mix well;

[0043] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0044] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0046] Take the following ingredients for the recipe

[0047] Chondroitin Sulfate

75g

dextrin

22g

Polyvinylpyrrolidone

3g

[0048] Prepare pellet formulations as follows:

[0049] (1) Take the chondroitin sulfate of the above-mentioned formula amount and add dextrin, pulverize it to a micronized level with a ball mill, and mix well;

[0050] (2) Polyvinylpyrrolidone is dissolved in an appropriate amount of water;

[0051] (3) The pellets are made by the centrifugal-fluidized pelletizing method.

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Abstract

The invention provides a chondroitin sulfate pellet preparation, which is prepared from chondroitin sulfate and pharmaceutic adjuvant. The pellet preparation is characterized in that the pharmaceutic adjuvant is excipient and bonding agent, wherein the pellet preparation comprises the following components in percentage by weight: 10 to 90 percent of the chondroitin sulfate, 3 to 89 percent of the excipient, and 1 to 7 percent of the bonding agent. The pellet preparation can be prepared into a slow-release preparation or an enteric-coated preparation as requested. The chondroitin sulfate pellet preparation has high dissolution rate and high bioavailability, and the method is simple and convenient and is easy to operate.

Description

Technical field: [0001] The invention relates to a micropill of natural food extract and a preparation method thereof, in particular to a micropill made of chondroitin sulfate and a preparation method thereof. Background technique: [0002] Chondroitin sulfate is a mucopolysaccharide extracted from animal cartilage. It plays an important role in the prevention and treatment of cardiovascular diseases and joint diseases. Chondroitin sulfate has been used as a health food or health medicine for a long time in the prevention and treatment of coronary heart disease, angina pectoris and myocardial infarction. , coronary atherosclerosis, myocardial ischemia and other diseases, without obvious toxic and side effects, can significantly reduce the morbidity and mortality of patients with coronary heart disease. At the same time, it has lipid-lowering, anti-inflammatory and weak anti-coagulant and anti-thrombotic biological activities, and plays an important role in maintaining the re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/737A61P3/06A61P7/02A61P9/10A61P19/02A61P29/00A23L1/30A23L33/10
Inventor 李红艳
Owner JF PHARMALAND TECH DEV
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