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Propolis micropill and preparation method thereof

A technology of propolis pellets and propolis, which is applied in the field of medicine and food, can solve the problems of gastric mucosa irritation, long disintegration time, and low bioavailability, and achieve the effects of good effectiveness, high bioavailability, and large dispersion area

Inactive Publication Date: 2009-06-03
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, propolis-related products are favored by consumers. These products are basically ordinary tablets, soft capsules and capsules, but the above-mentioned dosage forms have a long disintegration time; Gastric mucosa is irritating to a certain extent; low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take the following ingredients for the recipe

[0033] propolis 15g starch 81g Hydroxypropylmethylcellulose 4g

[0034] Prepare pellet formulations as follows:

[0035] (1) Get the propolis of above-mentioned formula amount and add starch, mix;

[0036] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0037] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0039] Take the following ingredients for the recipe

[0040] propolis 45g starch 52g Polyvinylpyrrolidone 3g

[0041] Prepare pellet formulations as follows:

[0042] (1) Get the propolis of above-mentioned formula amount and add starch, mix;

[0043] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0044] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0046] Take the following ingredients for the recipe

[0047] propolis 64g Crystalline Cellulose 32.5g Hydroxypropylmethylcellulose 3.5g

[0048] Prepare pellet formulations as follows:

[0049] (1) Get the propolis of above-mentioned formula amount and add dimension crystal cellulose, mix;

[0050] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;

[0051] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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PUM

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Abstract

The invention provides a preparation of propolis micropill which is made of propolis and medical accessories and is characterized in that the medical accessories comprise excipient and bond. The preparation of the micropill is made of the following components by the weight percentage: 5-80 percent of propilis, 20-95 percent of excipient and 1-5 percent of bond. The preparation of the micropill has the advantages of high stripping rate and high bioavailability, and the preparation method is simple and convenient and can be operated easily.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of propolis and a preparation method thereof. Background technique: [0002] Propolis is a miraculous natural biological resource. It is a resin with aromatic flavor that bees collect from new shoots or bark of long-lived gum source plants in nature, and mix it with their own mandibular gland secretions. shape mixture. According to the analysis of modern science and technology, propolis contains the essence of animals and plants, and its ingredients are very complex, including a variety of strong physiologically active substances, such as flavonoids, phenols, terpenes, organic acids and various amino acids, enzymes, vitamins, minerals etc. Researchers at the University of Oxford found that among the various components contained in propolis, there are more than one hundred natural crude drug components, so some people say that propolis is like a "small d...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/16A61P1/00A61P3/06A61P3/10A61P17/16A61P25/20A61P37/02A61P39/06A61K35/644
Inventor 丁利营
Owner JF PHARMALAND TECH DEV
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