Vitamin E micropill and preparation method thereof
A vitamin and pellet technology, applied in the field of medicine and food, can solve the problems of gastric mucosa irritation, long disintegration time, low bioavailability, etc., and achieve the effects of good effectiveness, high bioavailability, and reducing the number of doses
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Embodiment 1
[0032] Take the following ingredients for the recipe
[0033] Vitamin E 10g starch 87g Hydroxypropylmethylcellulose 3g
[0034] Prepare pellet formulations as follows:
[0035] (1) Take the vitamin E in the above-mentioned formula amount and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;
[0036] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;
[0037] (3) The extrusion-spheronization method is used to make pellets.
Embodiment 2
[0039] Take the following ingredients for the recipe
[0040] Vitamin E 30g starch 66g Polyvinylpyrrolidone 4g
[0041] Prepare pellet formulations as follows:
[0042] (1) Take the vitamin E in the above-mentioned formula amount and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;
[0043] (2) the adhesive polyvinylpyrrolidone is dissolved in water;
[0044] (3) Micro-pills were made by pan-pill method.
Embodiment 3
[0046] Take the following ingredients for the recipe
[0047] Vitamin E 55g
[0048] Crystalline Cellulose 43g Hydroxypropylmethylcellulose 2g
[0049] Prepare pellet formulations as follows:
[0050] (1) Add the vitamin E of the above-mentioned formula amount to the crystal cellulose, pulverize it to a micronized level with a ball mill, and mix well;
[0051] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;
[0052] (3) The centrifugal-fluidized pelletizing method is used to make pellets.
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