Vitamin E micropill and preparation method thereof

A vitamin and pellet technology, applied in the field of medicine and food, can solve the problems of gastric mucosa irritation, long disintegration time, low bioavailability, etc., and achieve the effects of good effectiveness, high bioavailability, and reducing the number of doses

Inactive Publication Date: 2009-06-03
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently developed vitamin E products are basically ordinary tablets, capsules and capsules, but the above-mentioned dosage forms have a long disintegration time; they disintegrate at a certain point in the body, which is irritating to the gastric mucosa; bioavailability Disadvantages such as low degree

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take the following ingredients for the recipe

[0033] Vitamin E 10g starch 87g Hydroxypropylmethylcellulose 3g

[0034] Prepare pellet formulations as follows:

[0035] (1) Take the vitamin E in the above-mentioned formula amount and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0036] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0037] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0039] Take the following ingredients for the recipe

[0040] Vitamin E 30g starch 66g Polyvinylpyrrolidone 4g

[0041] Prepare pellet formulations as follows:

[0042] (1) Take the vitamin E in the above-mentioned formula amount and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0043] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0044] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0046] Take the following ingredients for the recipe

[0047] Vitamin E 55g

[0048] Crystalline Cellulose 43g Hydroxypropylmethylcellulose 2g

[0049] Prepare pellet formulations as follows:

[0050] (1) Add the vitamin E of the above-mentioned formula amount to the crystal cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0051] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;

[0052] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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Abstract

The invention provides a preparation of a vitamin E micropill which is made of vitamin E and medical accessories and is characterized in that the medical accessories comprise excipient and bond. The preparation of the micropill is made of the following components by the weight percentage: 1-85 percent of vitamin E, 15-99 percent of excipient and 1-5 percent of bond. The preparation of the micropill has the advantages of high stripping rate and high bioavailability, and the preparation method is simple and convenient and can be operated easily.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a micropill made of vitamin E and a preparation method thereof. Background technique: [0002] In 1922, American scientist Ivan discovered that the fertility of male white mice decreased, and the easy abortion of female white mice was related to the lack of a fat-soluble substance. In 1938, Swiss chemist Carla synthesized this substance and named it tocopherol, which is vitamin E. Tocopherol can promote the secretion of sex hormones, increase the vitality and quantity of sperm in men; increase the concentration of estrogen in women, improve fertility, and prevent miscarriage. It can also prevent menopausal syndrome. Vitamin E has the most extensive effect in the human body, greater than any other nutrient, so it is called "guardian". Has good antioxidant properties in the body, i.e. reduces cell aging. Maintain the integrity of red blood cells, promote cell synthes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/355A61P39/06
Inventor 丁利营
Owner JF PHARMALAND TECH DEV
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