Compound hyaluronic acid pellet and preparation method thereof
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A technology of hyaluronic acid and hyaluronic acid, applied in the field of medicine and food, to achieve the effect of high bioavailability and rapid onset of action
Inactive Publication Date: 2015-06-03
JF PHARMALAND TECH DEV
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Abstract
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Problems solved by technology
[0002]There are many health care products with hyaluronic acid and VC alone, but there is no report about the compound preparation of the two. At present, the products of hyaluronic acid and VC Recognized by the majority of consumers, these products are basically ordinary tablets and capsules except for unilateral preparations, but the above-mentioned dosage forms have a long disintegration time; Certain irritation; low bioavailability and other disadvantages
Method used
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Embodiment 1
[0030] Take the following ingredients for the recipe
[0033] (1) Take hyaluronic acid and VC in the amount of the above formula, add microcrystalline cellulose, grind to micronized level with a ball mill, and mix well;
[0034] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;
[0035] (3) Micro-pills are made by extrusion-spheronization into pellets.
Embodiment 2
[0037] Take the following ingredients for the recipe
[0047] (1) Take the hyaluronic acid and VC in the amount of the above formula, add sucrose and starch, grind to micronized level with a ball mill, and mix well;
[0048] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;
[0049] (3) Using the centrifugal-fluidized pelleting method to make pellets.
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Abstract
The invention provides a compound hyaluronic acid pellet preparation. The compound hyaluronic acid pellet preparation is prepared from hyaluronic acid, VC and pharmaceutical accessories and is characterized in that the pharmaceutical accessories include an excipient and an adhesive; and the compound hyaluronic acid pellet preparation contains 5-20% by weight of hyaluronic acid, 1-5% by weight of VC, 70-85% by weight of the excipient and 1-5% by weight of the adhesive. The compound hyaluronic acid pellet preparation disclosed by the invention has high dissolution rate and bioavailability; and a preparation method is simple, convenient and easy to operate.
Description
Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of compound hyaluronic acid and a preparation method thereof. Background technique: [0002] There are many unilateral health products of hyaluronic acid and VC, but there is no report about the compound preparations of the two. At present, the products about hyaluronic acid and VC are well recognized by consumers, and these products are not only unilateral preparations , are basically ordinary tablets and capsules, but the above-mentioned dosage forms have the disadvantages of long disintegration time; disintegration at a certain point in the body, which has certain irritation to the gastric mucosa; and low bioavailability. Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable release in the body an...
Claims
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Application Information
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