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Compound hyaluronic acid pellet and preparation method thereof

A technology of hyaluronic acid and hyaluronic acid, applied in the field of medicine and food, to achieve the effect of high bioavailability and rapid onset of action

Inactive Publication Date: 2015-06-03
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002]There are many health care products with hyaluronic acid and VC alone, but there is no report about the compound preparation of the two. At present, the products of hyaluronic acid and VC Recognized by the majority of consumers, these products are basically ordinary tablets and capsules except for unilateral preparations, but the above-mentioned dosage forms have a long disintegration time; Certain irritation; low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take the following ingredients for the recipe

[0031] hyaluronic acid 15g VC 1g Crystalline Cellulose 80g Hydroxypropylmethylcellulose 4g

[0032] Prepare pellet formulations as follows:

[0033] (1) Take hyaluronic acid and VC in the amount of the above formula, add microcrystalline cellulose, grind to micronized level with a ball mill, and mix well;

[0034] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;

[0035] (3) Micro-pills are made by extrusion-spheronization into pellets.

Embodiment 2

[0037] Take the following ingredients for the recipe

[0038] hyaluronic acid 10g VC 3g starch 82g Polyvinylpyrrolidone 5g

[0039] Prepare pellet formulations as follows:

[0040] (1) Take the hyaluronic acid and VC in the amount of the above formula, add starch, grind to micronized level with a ball mill, and mix well;

[0041] (2) Dissolve the adhesive polyvinylpyrrolidone in water;

[0042] (3) Micro-pills are made by pan-pill method.

Embodiment 3

[0044] Take the following ingredients for the recipe

[0045] hyaluronic acid 8g VC 5g sucrose 49g starch 34g Polyvinylpyrrolidone 4g

[0046] Prepare pellet formulations as follows:

[0047] (1) Take the hyaluronic acid and VC in the amount of the above formula, add sucrose and starch, grind to micronized level with a ball mill, and mix well;

[0048] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;

[0049] (3) Using the centrifugal-fluidized pelleting method to make pellets.

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PUM

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Abstract

The invention provides a compound hyaluronic acid pellet preparation. The compound hyaluronic acid pellet preparation is prepared from hyaluronic acid, VC and pharmaceutical accessories and is characterized in that the pharmaceutical accessories include an excipient and an adhesive; and the compound hyaluronic acid pellet preparation contains 5-20% by weight of hyaluronic acid, 1-5% by weight of VC, 70-85% by weight of the excipient and 1-5% by weight of the adhesive. The compound hyaluronic acid pellet preparation disclosed by the invention has high dissolution rate and bioavailability; and a preparation method is simple, convenient and easy to operate.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of compound hyaluronic acid and a preparation method thereof. Background technique: [0002] There are many unilateral health products of hyaluronic acid and VC, but there is no report about the compound preparations of the two. At present, the products about hyaluronic acid and VC are well recognized by consumers, and these products are not only unilateral preparations , are basically ordinary tablets and capsules, but the above-mentioned dosage forms have the disadvantages of long disintegration time; disintegration at a certain point in the body, which has certain irritation to the gastric mucosa; and low bioavailability. Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable release in the body an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A23L1/302A23L33/125
CPCA23V2002/00
Inventor 不公告发明人
Owner JF PHARMALAND TECH DEV
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