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Lutein pellet and preparation method thereof

A technology of lutein and pellets, applied in the field of medicine and food, can solve the problems of long disintegration time, gastric mucosa irritation, low bioavailability, etc. Effect

Inactive Publication Date: 2014-06-11
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, products about lutein are well received by consumers. These products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; The mucous membrane is irritating to a certain extent; the disadvantages such as low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Take the following ingredients for the recipe

[0036] Lutein 15g (based on pure product) Crystalline Cellulose 81 Hydroxypropylmethylcellulose 4g

[0037] Prepare pellet formulations as follows:

[0038] (1) Take the lutein in the above formula and add it to the crystal cellulose, grind it to a micronized level with a ball mill, and mix well;

[0039] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;

[0040] (3) Micro-pills are made by extrusion-spheronization into pellets.

Embodiment 2

[0042] Take the following ingredients for the recipe

[0043] Lutein 10g (based on pure product) starch 85g Polyvinylpyrrolidone 5g

[0044] Prepare pellet formulations as follows:

[0045](1) Add the lutein in the amount of the above formula to starch, grind it to a micronized level with a ball mill, and mix well;

[0046] (2) Dissolve the adhesive polyvinylpyrrolidone in water;

[0047] (3) Micro-pills are made by pan-pill method.

Embodiment 3

[0049] Take the following ingredients for the recipe

[0050] Lutein 8g (based on pure product) sucrose 54 starch 34g Polyvinylpyrrolidone 4g

[0051] Prepare pellet formulations as follows:

[0052] (1) Take the lutein in the amount of the above formula, add sucrose and starch, grind it to a micronized level with a ball mill, and mix well;

[0053] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;

[0054] (3) Using the centrifugal-fluidized pelleting method to make pellets.

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Abstract

The invention provides a lutein pellet, which is prepared from lutein and a pharmaceutic adjuvant. The lutein pellet is characterized in that the pharmaceutic adjuvant is an excipient and an adhesive, wherein the pellet preparation contains 5-20% of lutein, 70-85% of excipient and 1-5% of adhesive. The lutein pellet disclosed by the invention is high in dissolution rate, and high in bioavailability, and the preparation method is simple, convenient and easy to operate.

Description

technical field [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of lutein and a preparation method thereof. Background technique [0002] Lutein and zeaxanthin are the main components of plant pigments such as vegetables, fruits, and flowers, and are also the main pigments that constitute the macular area of ​​the human eye. Human eyes contain a high amount of lutein, which cannot be produced by the human body and must be supplemented by intake of lutein. Without this element, the eyes will be blind. Foreign studies have shown that: lutein can prevent eye light damage, prevent visual atrophy and blindness caused by lutein deficiency, as well as cardiovascular sclerosis, coronary heart disease and tumor diseases caused by body aging. It is the main component that cannot be missing from the retina and macula of the eye; it prevents the physiological structure and function of the eye from changing; it is a powerful antio...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/047A61P27/02A61P39/06A61P9/08A61P3/02A23L1/29A23L33/00
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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