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3 results about "Lysyl oxidase" patented technology
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Lysyl oxidase (LOX), also known as protein-lysine 6-oxidase, is an enzyme that, in humans, is encoded by the LOX gene. It catalyzes the conversion of lysine molecules into highly reactive aldehydes that form cross-links in extracellular matrix proteins. Its inhibition can cause osteolathyrism, but, at the same time, its upregulation by tumor cells may promote metastasis of the existing tumor, causing it to become malignant and cancerous.
Inhibitors of lysyl oxidase
In general, disclosed herein are lysyl oxidase (LOX) family inhibitors of Formula (A): or a pharmaceutically acceptable salt thereof. Additionally, disclosed herein are methods directed to treating a disease of condition associated with the modulation or inhibition of lysyl oxidase (LOX).
Owner:UNIVERSITY OF SOUTH CAROLINA +1
Bioprobes for lysyl oxidases and uses thereof
The present invention relates to novel bioprobes which are capable of binding to certain amine oxidase enzymes. These bioprobes are useful in methods of detecting and determining the concentration of certain amine oxidase enzymes in a sample as well as in methods for the quantitative assessment of inhibition of certain amine oxidases.
Owner:SYNTARA LTD