Antibacterial human-like collagen wound care film dressing

Abstract

The invention discloses novel antibacterial human-like collagen wound care film dressing which has good biocompatibility, is absorbable and is enriched with calcium, zinc, copper and silver elements as well as a preparation method of the film dressing. According to the preparation method, modified protein obtained by chelating calcium, zinc and copper ions on human-derived human-like collagen prepared through high-density fermentation is taken as a raw material, lysyl oxidase in a mammal body is taken as a cross-linking agent, and the novel antibacterial human-like collagen wound care film dressing which can be used for burn scald and skin wound is obtained through supporting of free silver ions due to the high absorption characteristic in the low-temperature crosslinking reaction and freeze drying process. Hidden danger caused by animal-derived viruses is avoided, and the hemostatic effect is remarkable; the contained silver ions can prevent the wound from being invaded by bacteria. The care dressing can be used for treating various wounds and has a wide application prospect.

Description

technical field [0001] The invention relates to a novel human collagen-like wound dressing and a preparation method thereof which are enriched in calcium, zinc, copper and silver elements. Background technique [0002] To treat various burns, scalds, ulcers, bedsores, and traumatic wounds, it is necessary to focus on the air permeability of the wound surface, prevent the loss of tissue fluid and body fluid, prevent surface infection of patients, and promote tissue repair, etc. However, although traditional wound dressings are cheap for a single dressing change and easy to obtain materials, they have obvious defects in the process of healing wounds: frequent dressing changes increase the probability of wound bacterial infection, and the dressing film adheres to secretions. When changing the dressing, the newly formed tissue is often damaged again, and the non-degradable and nutrient absorption of the dressing material is not conducive to the self-repair of the wound surface. ...

AI Technical Summary

Problems solved by technology

However, although traditional wound dressings are cheap for a single dressing change and easy to obtain materials, they have obvious defects in the process of healing wounds: frequent dressing changes increase the probability of wound bacterial infection, and the dressing film adheres to secretions. When changing the dressing, the newly formed tissue is often damaged again, and the non-degradable and nutrient absorption of the dressing material is not conducive to the self-healing of the wound surface

For example, although the silver ion antibacterial dressing can prevent bacterial infection very well, it has a complex structure (up to 5 layers inside and outside), and the material of the membrane dressing cannot be absorbed by nutrients. Undoubtedly, the healing is slow, and multiple dressing changes are required, which is economical and economical for the patient. It brings a burden in time; although collagen film dressing is a kind of fibrin in animals, it has good biocompatibility and degradable nutrient absorption, which is beneficial to wound repair and improves the effect of wound repair, but currently The collagen of the popular collagen-based membrane dressings is derived from animal extracts, which has unpredictable potential virus risks, and the price of collagen-based dressings is relatively expensive

At present, there is no wound dressing that can simultaneously have the characteristics of strong hemostasis, absorption of wound secretions, good air permeability, anti-bacterial properties, degradable and nutritional absorption, no hidden dangers of animal-derived viruses, and low cost.

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