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Wound healing compositions and methods using tropoelastin and lysyl oxidase

a technology of lysyl oxidase and composition, which is applied in the direction of drug composition, bandages, peptide/protein ingredients, etc., can solve the problems of unavoidable fibrin clot formation, no aesthetics nor functional perfection, and inability to achieve the effect of promoting healing, promoting healing, and reducing scarring

Inactive Publication Date: 2005-08-11
MATRIX DESIGN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides a composition and method for promoting wound healing by using virgin monomers of tropoelastin and the cross-linking enzyme, lysyl oxidase. The two components are mixed together and applied to a wound before substantial cross-linking has occurred. The lysyl oxidase catalyzes the oxidative deamination of the lysine residues of the tropoelastin monomers at the site of the wound, and the cross-linked elastin helps hold the wounded tissue together and promotes healing. The composition can be applied only once at the time of the injury or multiple times over the course of wound healing. It can also be used in surgeries involving arteries, lungs, or the skin. The composition is biocompatible, non-toxic, and non-immunogenic."

Problems solved by technology

Most wounds heal rapidly and efficiently within a week or two; however, the result is neither aesthetically nor functionally perfect.
Wound contraction and scar formation are currently unavoidable results of wound healing.
Immediately after tissue injury, blood vessel disruption leads to the extravasation of blood and concomitant platelet aggregation and blood coagulation resulting in fibrin clot formation.

Method used

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  • Wound healing compositions and methods using tropoelastin and lysyl oxidase

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Embodiment Construction

[0035] As described above, the present invention provides compositions and methods for promoting wound healing. These compositions comprise tropoelastin and lysyl oxidase. The method of the present invention involves contacting these two components together and applying the mixture to a wound before substantial cross-linking of the tropoelastin has taken place. In another embodiment, the tropoelastin and lysyl oxidase are applied separately to the wound. A key aspect of the invention is that the tropoelastin must be applied to the wound before substantial cross-linking of the tropoelastin has occurred. To those skilled in the art, a variety of ways of applying the two substances wherein the tropoelastin is not substantially cross-linked will be clear. With the cross-linking reaction taking place at the wound site, cross-links will form that will hold the tissue together. Also, the new formation of elastin will attract fibroblasts, inflammatory cells, and endothelial cell by chemotax...

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Abstract

The present invention provides compositions and methods for promoting wound healing. The composition comprises virgin monomers of tropoelastin and lysyl oxidase. When the lysyl oxidase comes in contact with the tropoelastin, cross-linking of the tropoelastin monomers will occur to form elastin. Contacting the tropoelastin and lysyl oxidase together and applying the mixture to a wound before substantial cross-linking has occurred promotes wound healing by holding the damaged tissue together, increasing the rate of healing, and decreasing the amount of scarring.

Description

BACKGROUND OF THE INVENTION [0001] Wound healing is a complex biological process that involves many different cell types, many different cytokines, the extracellular matrix (ECM), and numerous interactions among them. Most wounds heal rapidly and efficiently within a week or two; however, the result is neither aesthetically nor functionally perfect. Wound contraction and scar formation are currently unavoidable results of wound healing. Scar tissue is less flexible than normal skin and can be cosmetically disfiguring, and wound contraction can lead to joint disablement (Lamme et al., J. Histochem. Cytochem. 44:1311, 1996). Scars lack elastin and consist of poorly reconstituted collagen matrix in dense parallel bundles rather than the mechanically efficient basket-weave meshwork of collagen in unwounded dermis (Martin, Science 276:75, 1997). Two major goals of wound-healing biology are more rapid wound healing and more perfect reconstruction of the damaged parts. Compositions and met...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/44A61L15/32A61L15/38A61L26/00
CPCA61K38/39A61K38/44A61L15/32A61L15/38C12Y104/03013A61L26/0047A61K2300/00A61P17/02
Inventor ENSLEY, BURT D.
Owner MATRIX DESIGN
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