Novel human-like collagen haemostatic dressing
A technology of human-like collagen and hemostatic dressings, which is applied in medical science, drug delivery, bandages, etc., can solve the problems of platelets and other hemostatic components, poor pulling ability and wound repair ability, eosinophilia, and pathogens carried by animals. , to achieve the effects of increasing the ion assisting effect, easy process amplification, and stable product quality
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Embodiment 1
[0023] Example 1 Preparation of Human Collagen Hemostatic Dressing Rich in Calcium, Zinc, Iron and Copper
[0024] According to the mass ratio of 100:2:2:1, take an appropriate amount of chelated calcium, zinc, iron, and copper-type human-like collagen respectively, dissolve them in an appropriate amount of deionized water, and prepare a concentration of 10% (w / v) collagen solution 100ml; add 0.05% (w / v) cross-linking agent lysine oxidase 2mL to the above protein solution under stirring, pour into the mold after mixing, and incubate at 25°C for 24h, Then transfer to an ultra-low temperature refrigerator to freeze for 2~4 hours; quickly move the ultra-low temperature frozen sample into a pre-cooled vacuum freeze dryer, vacuum freeze dry for 24~48 hours, take out the package, and sterilize with Co60 irradiation to obtain degradable human collagen Hemostatic dressing. The appearance photos of the prepared novel hemostatic dressing are as follows: figure 1 As shown, the SEM i...
Embodiment 2
[0025] Example 2 Preparation of Human Collagen Hemostatic Dressing Rich in Calcium, Zinc, Iron and Copper
[0026] According to the mass ratio of 100:3:4:1, take an appropriate amount of chelated calcium, zinc, iron, and copper-type human-like collagen respectively, dissolve them in an appropriate amount of deionized water, and prepare a concentration of 5% (w / v) 200ml of collagen solution; under stirring, add 0.4ml of cross-linking agent lysine oxidase with a mass fraction of 0.5% to the above protein solution, mix well and pour into the mold, keep it warm at 20°C for 48h, and then Transfer to an ultra-low temperature refrigerator and freeze for 2-4 hours; quickly move the ultra-low temperature frozen sample into a pre-cooled vacuum freeze dryer, vacuum freeze-dry for 24-48 hours, take out the package, and sterilize it with Co60 irradiation to obtain degradable human collagen for hemostasis dressing.
Embodiment 3
[0027] Example 3 Preparation of Human Collagen Hemostatic Dressing Rich in Calcium, Zinc, Iron and Copper
[0028] According to the mass ratio of 400:10:10:1, take an appropriate amount of chelated calcium, zinc, iron, and copper-type human-like collagen respectively, dissolve them in an appropriate amount of deionized water, and prepare a concentration of 15% (w / v) 200ml of collagen solution; under stirring, add 6mL of cross-linking agent lysine oxidase with a mass fraction of 0.05% (w / v) to the above protein solution, mix well and pour into the mold, at 45°C Insulate for 5 hours, then transfer to an ultra-low temperature refrigerator to freeze for 2-4 hours; quickly move the ultra-low temperature frozen sample into a pre-cooled vacuum freeze dryer, vacuum freeze-dry for 24-48 hours, take out the package, and sterilize it with Co60 irradiation to obtain degradable human resources Type collagen hemostatic dressing.
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