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Collagen protein micro-pill and preparation method thereof

A technology of collagen and pellets, applied in the field of medicine and food, can solve the problems of low bioavailability, irritation of gastric mucosa, long disintegration time, etc., achieve high bioavailability, good effectiveness, and reduce the total dose

Inactive Publication Date: 2009-06-17
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently developed collagen-related products are basically ordinary tablets and capsules, but these dosage forms have a long disintegration time; they disintegrate at a certain point in the body, which is irritating to the gastric mucosa; bioavailability Disadvantages such as low degree

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take the following ingredients for the recipe

[0032] Collagen 30g starch 67g Hydroxypropylmethylcellulose 3g

[0033] Prepare pellet formulations as follows:

[0034] (1) Take the above-mentioned amount of collagen and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0035] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0036] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0038] Take the following ingredients for the recipe

[0039] Collagen 50g starch 46g Polyvinylpyrrolidone 4g

[0040] Prepare pellet formulations as follows:

[0041] (1) Take the above-mentioned amount of collagen and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0042] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0043] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0045] Take the following ingredients for the recipe

[0046] Collagen 75g Crystalline Cellulose 23g Hydroxypropylmethylcellulose 2g

[0047] Prepare pellet formulations as follows:

[0048] (1) Take the above-mentioned amount of collagen and add it to crystal cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0049] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;

[0050] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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Abstract

The invention provides a collagen pellet preparation, which is prepared from a collagen and a pharmaceutic adjuvant. The collagen pellet preparation is characterized in that the pharmaceutic adjuvant is an excipient and an adhesive; the weight percentage of the collagen in the pellet preparation is between 10 and 90 percent; the weight percentage of the excipient is between 20 and 80 percent; and the weight percentage of the adhesive is between 1 and 5 percent. The pellet preparation of the invention has the advantages of high dissolution rate, high bioavailability, simple and convenient preparation method, and easy operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a micropill made of collagen and a preparation method thereof. Background technique: [0002] Collagen, also known as collagen, is a protein widely distributed in the body. It mainly exists in the skin, muscles, bones, cartilage, teeth, internal organs and eyes in the human body. Its main function is to maintain the shape and shape of the skin, tissues and organs. It is also an important raw material for repairing various damaged tissues. About 16% of the body composition is protein, and collagen accounts for 25-35% of the total protein in a healthy human body, which is equivalent to 6% of body weight. Although collagen accounts for such a small proportion, it plays a very important role. Collagen can maintain the elasticity between cells, increase the elasticity of the skin and make it delicate and shiny; it can connect cells and cells, promote metabolism, and mainta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K9/16A61P3/02A61P19/10
Inventor 吕建营
Owner JF PHARMALAND TECH DEV
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