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Folium ginkgo extract micropill and preparation method thereof

An extract and technology of ginkgo biloba, applied in the field of pellets made of ginkgo biloba extract and its preparation, can solve the problems of long disintegration time, low bioavailability, irritation of gastric mucosa, etc., and achieve good effectiveness, High bioavailability, total dose reduction effect

Inactive Publication Date: 2009-06-03
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are not many Ginkgo biloba extract products on the market, but they are all ordinary tablets and capsules. The above-mentioned dosage forms have a long disintegration time and disintegrate at a certain point in the body, which is irritating to the gastric mucosa, Disadvantages such as low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take the following ingredients for the recipe

[0035] Ginkgo biloba extract 10g microcrystalline cellulose 85g Hydroxypropylmethylcellulose 5g

[0036] Prepare pellet formulations as follows:

[0037] (1) Take the Ginkgo biloba extract of the above-mentioned formula amount and add microcrystalline cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0038] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0039] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0041] Take the following ingredients for the recipe

[0042] Ginkgo biloba extract 40g sucrose 55g Polyvinylpyrrolidone 5g

[0043] Prepare pellet formulations as follows:

[0044] (1) Take the Ginkgo biloba extract of the above-mentioned formula amount and add sucrose, pulverize it to a micronized level with a ball mill, and mix well;

[0045] (2) polyvinylpyrrolidone is dissolved in water;

[0046] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0048] Take the following ingredients for the recipe

[0049] Ginkgo biloba extract 60g sucrose 25g starch 11g Polyvinylpyrrolidone 4g

[0050] Prepare pellet formulations as follows:

[0051] (1) Take the Ginkgo biloba extract of the above-mentioned formula amount, add sucrose and starch, pulverize it to a micronized level with a ball mill, and mix well;

[0052] (2) polyvinylpyrrolidone is dissolved in water;

[0053] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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PUM

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Abstract

The invention provides a preparation of a folium ginkgo extract micropill which is made of a folium ginkgo extract and medical accessories and is characterized in that the medical accessories comprise excipient and bond. The preparation of the folium ginkgo extract micropill is made of the following components by the weight percentage of 0.5-85 percent of folium ginkgo extract, 15-99.5 percent of excipient and 1-5 percent of bond. The preparation of the micropill has the advantages of high stripping rate and high bioavailability, and the preparation method is simple and convenient and can be operated easily.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of ginkgo biloba extract and a preparation method thereof. Background technique: [0002] In ancient my country, Ginkgo biloba was used to treat diseases. Wu Rui's "Daily Materia Medica" in the Yuan Dynasty has records of the medicinal value of ginkgo. Later, a large number of herbal classics represented by Li Shizhen's "Compendium of Materia Medica" were introduced. Folks use it to treat warts, spleen deficiency under the damp heat, head and face ringworm, asthma, shortness of breath, blood in the stool, bone steaming fever, chronic bronchitis, nocturnal emission and other diseases. Ancient and modern medical circles believe that ginkgo is a good traditional Chinese medicine and is widely used in clinical treatment. It is said that its broad-spectrum healing properties are one of the few traditional Chinese medicines. [0003] Ginkgo biloba extract c...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K9/16A61P9/00A61P25/28A61P39/06A61K127/00
Inventor 王巍
Owner JF PHARMALAND TECH DEV
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