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Alginate dressing containing composite silver-zinc antibacterial agents and preparation method thereof

The technology of antibacterial agent and alginate is applied in the field of alginate dressing containing composite silver-zinc antibacterial agent and its preparation field, and can solve the problems of low silver-containing concentration, increased process, labor and time cost, limitation of antibacterial performance, and the like, Achieve the effect of strong bactericidal ability, good formula stability and high antibacterial and bactericidal efficiency

Active Publication Date: 2015-09-30
SHENZHEN TSINGHUA YUANXING NANO MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the particles of AlphaSan RC5000 are very fine, when mixed with sodium alginate solution under high shear, these fine particles can be evenly distributed in the viscous spinning solution, so that the formed fibers are evenly distributed with silver Particles, and the fibers retain their white appearance even after being sterilized with Y-rays, also with their low silver concentration, their antimicrobial properties are limited
[0004] Silver-loaded dressings on the market generally use fiber products to attach to medical dressings by dipping, coating, spraying, and adsorption. The reprocessing process increases the cost of technology, manpower, and time.

Method used

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  • Alginate dressing containing composite silver-zinc antibacterial agents and preparation method thereof
  • Alginate dressing containing composite silver-zinc antibacterial agents and preparation method thereof
  • Alginate dressing containing composite silver-zinc antibacterial agents and preparation method thereof

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preparation example Construction

[0036] The present invention also provides a kind of preparation method of the above-mentioned alginate dressing containing composite silver-zinc antibacterial agent, comprising the following steps:

[0037] (1) Preparation of composite silver-zinc antibacterial agent: take silver compound, zinc compound and inert carrier, mix the three evenly, and place them in a porcelain dish; then put them into a high-temperature furnace and burn them at 1000°C for 3 hours; 200 mesh sieve, take the under-sieve, mix evenly, and obtain the composite silver-zinc antibacterial agent;

[0038] (2) Preparation of alginate solution: Soak alginate at 30°C-40°C for 2h-3h to pre-dissolve, then stir at a temperature of 40°C-60°C and a speed of 200r / min-400r / min Stir for 3h-4h or at a temperature of 30°C-60°C and a speed of 200r / min-400r / min for 4h-7h, and finally filter with a filter cloth under a pressure of 2-3kg to obtain the alginate solution;

[0039] (3) Preparation of spinning stock solution:...

Embodiment 1-6

[0054] The proportioning of specific embodiments of the present invention is shown in Table 1.

[0055] The following raw materials are taken in parts by weight: 0.4-1.4 parts of composite antibacterial powder; 84.6-95.6 parts of purified water; 4-14 parts of alginate. Wherein, in the composite antibacterial powder used in Examples 1-6, the mass fraction of nano silver in the composite antibacterial powder is 20%, and the mass fraction of nano zinc in the composite antibacterial powder is 40%.

[0056] Table 1 The proportioning table of Embodiment 1-6

[0057]

[0058]

[0059] The above-mentioned raw materials are prepared according to the following steps to contain the alginate dressing of compound silver-zinc antibacterial agent, and it comprises the following steps successively:

[0060] (1) Preparation of composite silver-zinc antibacterial agent: take silver compound, zinc compound and inert carrier, mix the three evenly, and place them in a porcelain dish; then p...

Embodiment 7-16

[0073] Studies have found that when the ratio of nano-silver and nano-zinc is within a certain range, their bactericidal effect will increase synergistically. Below, under the raw material proportioning of embodiment 2, observe the influence that the alginate fiber dressing containing different proportioning nano-silver and nano-zinc has antibacterial and bactericidal effect on Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans , the results are shown in Table 3.

[0074] Table 3: Effects of different ratios of nano-silver and nano-zinc on the bactericidal rate of alginate fiber dressings

[0075]

[0076] As can be seen from Table 3, the alginate dressing containing the composite silver-zinc antibacterial agent of the present invention has a strong antibacterial and bactericidal effect on Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans, and the bactericidal effect can reach more than 95%. And when nano-silver accounts for 20% in the weight...

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Abstract

The invention discloses an alginate dressing containing composite silver-zinc antibacterial agents. The alginate dressing is prepared by the following raw materials through spinning, wherein the raw materials comprise, by weight, 0.4-1.4 part composite silver-zinc antibacterial agents, 84.6-95.6 parts of purified water and 4-14 parts of alginate. The composite silver-zinc antibacterial agents applied to the alginate dressing has the advantages that the dispensation is good in stability, and the alginate dressing is low in toxicity and free of stimulation and sensitization, has good biocompatibility and high moisture absorption performance, and is easy to remove, high in oxygen permeation, biodegradability and biocompatibility, high in antibacterial sterilization efficiency, and good in treatment effect. The composite silver-zinc antibacterial agents are added to the alginate dressing, the composite silver-zinc antibacterial agents contain two antimicrobial components of nano-silver and nano-zinc, the preparation of the two antimicrobial components is in a certain range, the antibacterial sterilization efficiency is high, and the treatment effect is good.

Description

technical field [0001] The present invention relates to the field of medical dressings, more specifically, relates to an alginate dressing containing a composite silver-zinc antibacterial agent that has excellent antibacterial properties, can promote wound healing, tissue repair and regeneration, and absorb wound exudate, and a preparation method thereof . Background technique [0002] In the course of work-life movements, people inevitably experience trauma. Skin wounds after trauma, burns or ulcers are prone to produce exudate, pus, toxins and toxic products, among which exudate contains a large number of inflammatory factors, proteases and free radicals, etc. If these harmful substances stay in the The surface of the skin slows down wound healing. Studies have shown that maintaining a moist environment on the wound surface is conducive to wound healing, so an ideal wound dressing should have the characteristics of promoting wound healing, rapid hemostasis and preventing...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61L15/18D04H1/4382D04H1/46D01D13/00
Inventor 刘龙清高培军王红梅陈育
Owner SHENZHEN TSINGHUA YUANXING NANO MATERIAL CO LTD
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