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Vesicle for enhancing skin penetration and preparation method of same

一种囊泡、使用量的技术，应用在护理皮肤的制剂、梳妆用配制品、含有效成分的医用配制品等方向，能够解决损伤角质层细胞间脂质结构、不能被视为化学促渗剂等问题

Active Publication Date: 2019-11-12
COSMAX INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as mentioned above, these components all damage the intercellular lipid structure of the stratum corneum itself, so they cannot be considered as preferred chemical penetration enhancers

Method used

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  • Vesicle for enhancing skin penetration and preparation method of same
  • Vesicle for enhancing skin penetration and preparation method of same
  • Vesicle for enhancing skin penetration and preparation method of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 and comparative example 1 to 3

[0050] Example 1 and Comparative Examples 1 to 3: Preparation of Vesicles Including Skin Absorption-Promoting Components

[0051] The vesicles of Example 1 and Comparative Examples 1 to 3 were prepared using different skin absorption promoting ingredients from each other. Specifically, vesicles were prepared by heating to 80°C to 90°C and dissolving Item B slowly poured into Item A at room temperature. Example 1 included ceramide as a skin absorption promoting ingredient, Comparative Example 1 did not include a skin absorption promoting ingredient, Comparative Example 2 included menthol as a skin absorption promoting ingredient, and Comparative Example 3 included ethanol as a skin absorption promoting ingredient.

[0052] The specific components and contents of the compositions prepared according to Example 1 and Comparative Examples 1 to 3 are shown in Table 1 below. Unless otherwise stated in this specification, the content of ingredients is % by weight.

[0053] [Table 1]...

Embodiment 2 to 6

[0061] Examples 2 to 6: Preparation of ceramide-containing vesicles

[0062] In order to stabilize ceramide in the dosage form, as shown in Table 3, the dosage forms of Examples 2 to 6 were prepared with different contents of polyoxyethylenecholesteryl ether (PCE) and hydrogenated lecithin. Specifically, the dosage form is prepared by slowly pouring into item B at room temperature after heating to 80°C to 90°C and dissolving item A.

[0063] [table 3]

[0064]

Embodiment 7

[0085] Example 7 and Comparative Example 4: Preparation of a ceramide-containing vesicle dosage form for testing the effect of promoting skin absorption

[0086] In order to examine the skin absorption promoting effect by said Test Example 4 with respect to the dosage form of Example 5 in which the effect of stabilizing ceramide in the dosage form was demonstrated, a vesicle dosage form was prepared with the ingredients and contents shown in Table 5 below. Retinol was used as a model drug. Specifically, after heating item A to 80°C to 90°C and dissolving it, a vesicle dosage form is prepared by slowly adding item B at room temperature. The only difference between Comparative Example 4 and Example 7 is the content of ceramide. That is, it is composed of the above ingredients to confirm how much influence ceramide has as a skin absorption enhancer.

[0087] [table 5]

[0088]

[0089]

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PUM

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Abstract

The disclosure relates to a vesicle for enhancing skin penetration and a preparation method of the same. In addition, the disclosure also relates to a cosmetic composition comprising the vesicle. According to an aspect of the method for producing a vesicle, it is possible to prepare a vesicle having an excellent skin penetration enhancing effect and excellent formulation stability. In addition, the vesicle prepared by the above method is safe because it does not irritate skin by using ceramide as a skin penetration enhancing ingredient while a skin penetration effect is excellent. As the vesicle has the excellent formulation stability including nonionic surfactants and phospholipids, the vesicle can be used as a cosmetic composition for enhancing the skin penetration effect of bioactive substances such as functional ingredients.

Description

technical field [0001] The present disclosure relates to a method for preparing a vesicle for promoting skin absorption, a vesicle prepared according to the method, and a cosmetic composition including the vesicle. Background technique [0002] The skin absorption of active ingredients is divided into three types according to the method of passing through the stratum corneum of the skin: the intercellular pathway through the lipid layer between the stratum corneum cells (Intercellular pathway); the intracellular pathway that directly moves between the corneocytes (Intracellular pathway) ; and the Follicular pathway. Among them, it is known that skin absorption through the intercellular route is the main skin absorption route. Therefore, the composition and structure of the intercellular lipids of the stratum corneum are important for the absorption of the active ingredient into the skin. [0003] It is known that the intercellular lipids of the stratum corneum are composed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/68A61K8/55A61K8/86A61K8/34A61Q19/00
CPCA61K8/14A61K8/68A61K8/553A61K8/86A61K8/345A61Q19/00A61K8/34A61K8/42A61K2800/592
Inventor 李俊培张芝姬卢玟朱张恩铣金秀智朴明三
Owner COSMAX INC
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