Composition for oral cavity

A composition and oral cavity technology, applied in the directions of oral cavity care, drug combination, drug delivery, etc., can solve problems such as difficulty in removal, and achieve the effects of high anti-inflammatory effect and excellent formulation stability

Active Publication Date: 2015-12-09
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to prevent periodontal disease, it is most important to remove the biofilm that is the root cause

Method used

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  • Composition for oral cavity
  • Composition for oral cavity
  • Composition for oral cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～18 and comparative example 1～4

[0099] Using the above components, the mouthwash compositions of Examples 1-18 and Comparative Examples 1-4 were prepared by the following preparation methods according to the mixing amounts shown in Tables 1-4. In addition, the compounding quantity of each component shown in Table 1-4 is the value (AI) converted into purity.

[0100] For the formulated mouthwash compositions, the anti-inflammatory effects and the stability of the formulations were evaluated according to the following steps. The evaluation results are shown in Tables 1-4.

[0101] (Preparation method of mouthwash composition)

[0102] Each component was mixed in 850 g of purified water at room temperature, and stirred for 1 hour until it was completely dissolved. When the pH is not within the range of 6.5-8.0, after adjusting the pH to within the range of 6.5-8.0 with sodium hydroxide, hydrochloric acid, etc., add purified water until the total amount of the composition becomes 1000 g. Separately, a 10% aqu...

Embodiment 19 and 20

[0132]Using the above ingredients, according to the mixing amounts shown in Tables 5 and 6, the dentifrice compositions of Examples 19 and 20 were prepared by the following preparation methods. In addition, the compounding quantity of each component shown in Table 5 and 6 is the value (AI) converted into purity.

[0133] For the formulated dentifrice compositions, the anti-inflammatory effects and formulation stability were evaluated according to the following procedure.

[0134] (Preparation method of dentifrice composition)

[0135] Mixture X was prepared by mixing and dissolving the following "(i) useful ingredients for mixture X" and "(ii) other additive ingredients for mixture X" in purified water at normal temperature. On the other hand, a mixture Y was prepared by dissolving or dispersing the following "(iii) Additional components for mixture Y" in propylene glycol at normal temperature. Next, Mixture Z was prepared by adding Mixture Y to Mixture X under stirring. Fi...

Embodiment 19

[0150] [Table 5] Embodiment 19 (toothpaste)

[0151]

[0152] Pyrrolidone carboxylic acid / allantoin = 4

[0153] For the dentifrice composition (toothpaste) of Example 19, both the anti-inflammatory effect and formulation stability were A.

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Abstract

Provided is a composition for the oral cavity, said composition exerting a high anti-inflammatory effect and having an excellent formulation stability. The composition for the oral cavity comprises: component (A) that is one or more kinds of lactam compounds selected from the group consisting of pyrrolidonecarboxylic acid, 6-oxo-2-piperidinecarboxylic acid, 3-(2-oxo-1-azepanyl)propanoic acid and salts thereof; and component (B) that is an anti-inflammatory agent.

Description

technical field [0001] The present invention relates to a composition for oral cavity. Background technique [0002] It is generally believed that about 80% of adults suffer from periodontal disease, but because of the lack of subjective symptoms, most of the time when it is discovered, it has become chronic and serious. In order to prevent periodontal disease, it is most important to remove the biofilm which is the root cause of inflammation, but at present, it is extremely difficult to remove the biofilm in the periodontal pocket by self-care. Therefore, the role of an anti-inflammatory agent is very important as a symptomatic treatment for periodontal disease. [0003] Conventionally, various anti-inflammatory agents such as glycyrrhizic acid and its salts have been mixed into oral compositions for the purpose of preventing and treating inflammation of periodontal tissues (for example, Patent Document 1). [0004] prior art literature [0005] patent documents [0006...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/44A61K8/46A61K8/60A61K8/63A61K45/00A61P1/02A61Q11/00
CPCA61Q11/00A61K8/4906A61K8/4913A61K8/4926A61K8/4946A61K8/63A61K9/0063A61K31/19A61K31/4015A61K31/4166A61K31/445A61K45/06A61K47/10A61K47/12A61K47/36A61K47/44A61K47/46A61P1/02A61K2300/00
Inventor 鬼木隆行井上志磨子
Owner LION CORP
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