Medical anti-adhesion material with controllable degradation and preparation method thereof

Abstract

The invention discloses a medical anti-adhesion membrane material with controllable degradation and a preparation method thereof, belonging to the field of biomedical materials. According to the invention, the membrane material is prepared by blending sodium hyaluronate and konjac klucomannan, using lactic acid as a property-modifying additive and using a mixed solution of ammonia water and anhydrous ethanol as a cross-linking agent; sodium hyaluronate is a good anti-adhesion material, but individually used sodium hyaluronate has a fast degradation speed and can not fulfill a good anti-adhesion effect; konjac klucomannan can control the degree of cross-linking, thereby realizing the goal of controllable degradation, and blending of sodium hyaluronate and konjac klucomannan enables sodium hyaluronate to be released slowly, thereby allowing the membrane material to meet demands for anti-adhesion action at different parts. The membrane material has the advantages of nontoxic degradation products, good biocompatibility, hygroscopicity and tensile properties, and the like, and can be used for intervertebral adhesion, intestinal adhesion, skin adhesion, intrauterine adhesion, etc.

Description

technical field [0001] The invention relates to a medical anti-adhesion film material with controllable degradation and a preparation method thereof, which can be used for lamina anti-adhesion, corneal adhesion, intestinal adhesion, uterine cavity adhesion, etc., and belongs to the field of biomedical materials. Background technique [0002] Postoperative adhesions are a common complication after surgery such as laminectomy, fibrosis and scarring around the dura mater [0003] The formation of scars can cause adhesion between the dura mater and the nerve root, thereby causing pressure on the dural sac, which is one of the main reasons for the failure syndrome of lower lumbar spine surgery; intestinal adhesion after laparotomy is also a major problem in clinical work. Due to postoperative adhesions, the incidence of intestinal obstruction is high, and repeated attacks affect the quality of life; intrauterine adhesions are a common gynecological disease, mainly caused by endom...

AI Technical Summary

Problems solved by technology

[0004] However, some anti-adhesion materials such as sodium hyaluronate gel, chitin gel and other fluid materials degrade relatively quickly, and are easy to lose with the change of body position. The short-term effect is better in the process of preventing adhesion, but the long-term effect is not good. Good; while some membrane materials, such as carboxymethyl chitosan membrane, will produce inflammatory response to the matrix (Zhou Gui et al., Chinese Tissue Engineering Research and Clinical Rehabilitation, 2009, 13 (18): 1411-1418), and the degradation is relatively slow Fast; polylactic acid is also a commonly used anti-adhesion material, but the degradation rate of polylactic acid film is slow, generally 3 to 6 months to fully absorb, and poor adhesion to the dura mater, easy to produce space between the dura mater and hematoma Existence is not conducive to the prevention of adhesion, especially the sealing and isolation of nerve roots (Sun Shaohua et al., Chinese journal of bone and joint injury.2006,21(7):590-591); but the material of the present invention is A kind of degradation is controllable, the degradation product is non-toxic, has good water absorption, can stop bleeding and reduce the formation of hematoma, good elasticity can be well attached to the adhesion part, and has good biological properties compatibility