Use of proanthocyanidin in preparing medicine for treating colitis

A technology of proanthocyanidins and colitis, applied in the field of proanthocyanidins in the preparation of drugs for the treatment of ulcerative colitis, which can solve the problems of large side effects, patient toxicity, and high recurrence rate of ulcerative colitis

Inactive Publication Date: 2006-03-15
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large side effects of these drugs, it is difficult for patients with ulcerative colitis to tolerate them. For example, long-term use of glucocorticoids, although the occurrence of inflammation is inhibited, the recurrence rate of ulcerative colitis is high, and patients are prone to unbearable toxicity. effect
In addition, the immunosuppressants 6-mercaptopurine and azathioprine are difficult to tolerate for a considerable number of patients
Indomethacin and NSAIDs not effective in treating ulcerative colitis

Method used

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  • Use of proanthocyanidin in preparing medicine for treating colitis
  • Use of proanthocyanidin in preparing medicine for treating colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1: The effect of proanthocyanidin treatment.

[0051] 1. Materials

[0052] 1.1 Animals: Wistar rats, weighing 260-320g, both male and female, provided by the Medical Experimental Animal Center of Lanzhou University.

[0053] 1.2 Drugs: proanthocyanidin extract: Jianfeng Natural Products Company, batch number: 20010131. Prednisone acetate: Xi'an Lijun Pharmaceutical Co., Ltd., batch number: 0408334.1.

[0054] 1.3 Main reagents: glacial acetic acid (Beijing Chemical Plant, batch number 000108, analytically pure); Coomassie Leucocyanin content, myeloperoxidase (MPO), superoxide dismutase (SOD), malondialdehyde (MDA), and Oxidized glutathione peroxidase (GSH-PX) and other kits were purchased from Nanjing Jiancheng Institute of Bioengineering, reagent batch number: 20041207.

[0055] 1.4 Main instruments: TGL type low-temperature high-speed centrifuge, manufactured by Shanghai Anting Scientific Instrument Factory; DY-2 type electric glass homogenizer, manufactur...

Embodiment 2

[0106] Example 2: The effect of oral administration of proanthocyanidins.

[0107] Methods: Rat models of acetic acid colitis were prepared, and there were 7 groups including normal control group, model control group, positive control group, proanthocyanidin intramuscular injection group, proanthocyanidin low-, medium-, and high-dose intragastric administration groups. Dosing once a day for 7 days. On the 8th day of administration, the general and histological scores of the rat lesion colon were performed; the MPO activity in the colon tissue was detected by the o-dianisidine method to investigate the degree of neutrophil infiltration; the nitrite method and dithiodinitrobenzene The activities of SOD and GSH-Px in the colon tissue were detected by the formic acid method, and the changes in the antioxidant capacity of the colon tissue were observed; the MDA content of the lipid peroxidation product in the colon tissue was determined by the thiobarbital chromogenic method, and t...

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Abstract

An application of proanthocyanidin in preparing the medicines for treating ulcerative colitis and non-bacteria chronic colitis is disclosed.

Description

Technical field: [0001] The invention mainly relates to the application of proanthocyanidins in the preparation of drugs for treating colitis. In particular, it relates to the use of proanthocyanidins in the preparation of medicines for treating ulcerative colitis. Background technique: [0002] Inflammatory bowel diseases such as chronic nonbacterial colitis are refractory and frequently occurring diseases. Ulcerative colitis (UC) is one of inflammatory bowel diseases (inflammatory bowel disease, IBD). It was first described by Wilks in 1875 as an independent colonic inflammatory disease different from bacillary dysentery. Recognized by the world, in 1956, our country reported domestic cases for the first time. It is a non-specific inflammatory bowel disease of unknown cause. The lesions are mainly located in the mucosal layer of the colon, mainly ulcers, mostly involving the rectum and distal colon, but can extend proximally and even throughout the entire colon. Histolo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P1/00
Inventor 吴勇杰杨孝来王莉鞠洋李文广高明堂
Owner LANZHOU UNIVERSITY
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