Use of proanthocyanidin in preparing medicine for treating colitis
A technology of proanthocyanidins and colitis, applied in the field of proanthocyanidins in the preparation of drugs for the treatment of ulcerative colitis, which can solve the problems of patients' intolerance, patient toxicity, and side effects, etc., and achieve novel ideas, unique ideas, and reliable evaluation effects
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Embodiment 1
[0049] Example 1: The effect of proanthocyanidin treatment.
[0050] 1. Materials
[0051] 1.1 Animals: Wistar rats, weighing 260-320g, both male and female, provided by the Medical Experimental Animal Center of Lanzhou University.
[0052] 1.2 Drugs: proanthocyanidin extract: Jianfeng Natural Products Company, batch number: 20010131. Prednisone acetate: Xi'an Lijun Pharmaceutical Co., Ltd., batch number: 0408334.1.
[0053] 1.3 Main reagents: glacial acetic acid (Beijing Chemical Plant, batch number 000108, analytically pure); Coomassie Leucocyanin content, myeloperoxidase (MPO), superoxide dismutase (SOD), malondialdehyde (MDA), and Oxidized glutathione peroxidase (GSH-PX) and other kits were purchased from Nanjing Jiancheng Institute of Bioengineering, reagent batch number: 20041207.
[0054] 1.4 Main instruments: TGL type low-temperature high-speed centrifuge, manufactured by Shanghai Anting Scientific Instrument Factory; DY-2 type electric glass homogenizer, manufactur...
Embodiment 2
[0111] Example 2: The effect of oral administration of proanthocyanidins.
[0112] Methods: Rat models of acetic acid colitis were prepared, and there were 7 groups including normal control group, model control group, positive control group, proanthocyanidin intramuscular injection group, proanthocyanidin low-, medium-, and high-dose intragastric administration groups. Dosing once a day for 7 days. On the 8th day of administration, the general and histological scores of the rat lesion colon were performed; the MPO activity in the colon tissue was detected by the o-dianisidine method to investigate the degree of neutrophil infiltration; the nitrite method and dithiodinitrobenzene The activities of SOD and GSH-Px in the colon tissue were detected by the formic acid method, and the changes in the antioxidant capacity of the colon tissue were observed; the MDA content of the lipid peroxidation product in the colon tissue was determined by the thiobarbital chromogenic method, and t...
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