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Cosmetic composition for skin whitening comprising arctiin, arctigenin or the mixture thereof as active ingredient

A cosmetic composition, arctigenin technology, applied in the field of skin whitening cosmetic composition, can solve the problems of reducing the whitening effect, stimulating the skin, reducing the stability of cosmetics, etc.

Active Publication Date: 2009-11-11
COREANA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the substances are extracts mixed with various ingredients, so using high concentrations of such substances may reduce the stability of cosmetics, irritate the skin, and relatively reduce the whitening effect depending on the concentration

Method used

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  • Cosmetic composition for skin whitening comprising arctiin, arctigenin or the mixture thereof as active ingredient
  • Cosmetic composition for skin whitening comprising arctiin, arctigenin or the mixture thereof as active ingredient
  • Cosmetic composition for skin whitening comprising arctiin, arctigenin or the mixture thereof as active ingredient

Examples

Experimental program
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Effect test

preparation example 1

[0036] Preparation Example 1: Preparation of Active Substances from Forsythia

[0037] 5 L of 95% ethanol was added to 1 kg of forsythia (fruit of Forsythia korean) powder washed with purified water, dried and powdered, and reflux stirring was performed. Then, by filtration and concentration, 33.2 g of a concentrate were obtained. Next, n-hexane was added, and a degreasing process (fractionation and separation) was performed to obtain 19.3 g of a concentrate. The concentrate was separated using cation exchange resin Diaion HP-20 (column 25 x 100 cm) by adding water and methanol, continuously increasing methanol concentration (10% methanol, 20% methanol, etc.). Of the fractions, the methanol fraction was concentrated to 60-80% to obtain 3.5 g of a concentrate, which was dissolved in methanol. Separated by LH-20 and MPLC, 0.63g of arctiin was obtained, and observed by NMR and mass spectrometry. Other active substances of forsythia, such as arctigenin, materesinol, pedicel, fo...

preparation example 2

[0038] Preparation Example 2: Preparation of a mixture of arctiin and arctigenin

[0039] Arctiin was extracted and prepared from Forsythia in the same manner as described in Preparation Example 1, mixed with arctigenin purchased from Sigma at a weight ratio of 1:3 to 3:1, and prepared at a high concentration (4,000ppm) Soluble in 1,3-butanediol.

experiment example 1

[0040] Experimental Example 1: Inhibition of Melanin Synthesis by Active Substances of Forsythia

[0041] α-MSH used in the melanin synthesis inhibition experiment was dissolved in 10% DMSO (dimethyl sulfoxide), and used as a 1 mM solution. B-16 melanoma (ATCC CRL 6323) cell line (from mice) was inoculated into DMEM medium containing 4.5g / L glucose, 10% serum and 1% antibiotics, and placed in a 75cm 2 In cell culture flasks at 37°C, 5% CO 2 Train next time. Subculture melanoma cell lines in 75cm 2 Cell culture flasks were cultured for 24 hours and treated with 0.05% trypsin containing 0.02% EDTA. Then, detach the cells and inoculate in 75cm 2 Cell culture flasks were further cultured for 6 hours. Here, the number of cells is 1×10 7 cells / flask. Then, melanocyte-stimulating hormone was diluted in DMEM medium to a final concentration of 100 μg / ml. Next, each of arctiin, arctigenin, materesinol, oleanolic acid, betulinic acid, rutin, and ursolic acid was diluted in DMEM m...

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Abstract

Present Invention relates to a skin whitening cosmetic composition comprising arctiin, arctigenin or a mixture thereof as an active ingredient. The disclosed composition can control or inhibit the synthesis of melanin by acting on a melanin synthesis route of alpha-MSH secreted by UV, and thus show an excellent whitening effect compared to a conventional skin whitening cosmetic. Also, the composition has high formulation stability and low skin irritation.

Description

technical field [0001] The present invention relates to a skin whitening cosmetic composition containing arctiin, arctigenin or a mixture thereof as an active ingredient. Background technique [0002] Everyone always wants to have white and fine skin. Generally speaking, the color of human skin, hair, eyes, etc. depends on melanin, carotene, heme, etc. In particular, melanin is also a major determinant of human skin color. In other words, skin color depends on the amount, nature and distribution of melanin. Pigments in human skin or hair play a role in protecting the skin or hair from the harmful effects of sunlight, especially UV rays. For example, a person who lacks this pigment is very sensitive to sunlight, suffers from burns, and therefore has a high chance of developing skin cancer even at a young age. Short-wavelength (290-320nm) ultraviolet rays and carcinogens form harmful free radicals such as oxygen free radicals in the skin, and thus such oxygen free radicals...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61Q19/02
CPCA61K8/602A61K8/4973A61Q19/02A61K8/49
Inventor 李正鲁催贞殷金相友李康泰李建国
Owner COREANA COSMETICS
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