210 results about "Melanin synthesis" patented technology

The invention discloses rhodiola rosea fermentation protoplasm cosmetic and a preparation method thereof. Efficient ingredients of the rhodiola rosea fermentation protoplasm cosmetic are supernate obtained by mixing powder of rhodiola rosea root, water and zymophyte to obtain an initial system, fermenting the initial system to obtain zymotic fluid and sterilizing and centrifuging the zymotic fluid. The zymophyte is saccharomycete. The rhodiola rosea root is subjected to whole plant fermentation by adopting the saccharomycete, all functional ingredients and activity of the plant are kept, and loss of active ingredients caused by an extracting method is avoided. Any organic reagents are not added during extraction, fermentation temperature and fermentation pH are mild, structure of plant active ingredients is not damaged, natural activity of the plant is kept, and chemical components of essence and the like are not added in the fermentation protoplasm so as to ensure the safety of products on the human body. The rhodiola rosea fermentation protoplasm cosmetic is rich in salidroside, arbutin and the like having activities of restraining tyrosinase activity and restraining melanin synthesis so as to have a relatively strong whitening function on skin and has a synergistic effect with the components in the fermentation filtrate simultaneously.

Present Invention relates to a skin whitening cosmetic composition comprising arctiin, arctigenin or a mixture thereof as an active ingredient. The disclosed composition can control or inhibit the synthesis of melanin by acting on a melanin synthesis route of α-MSH secreted by UV, and thus show an excellent whitening effect compared to a conventional skin whitening cosmetic. Also, the composition has high formulation stability and low skin irritation.

The present invention provides a whitening cosmetic composition comprising a stem cell, a culture medium thereof or a protein isolated from the culture medium and a method of whitening a skin which comprises administering to the skin an therapeutically effective amount of a stem cell, a culture medium thereof or a protein isolated from the culture medium.

The invention relates to a whitening composition (uniGlow) and an application thereof. The whitening composite comprises phenylbenzimidazole sulfonic acid, hydroxyphenylpropylamide benzoic acid, dipotassium glycyrrhizinate, undecylenoyl phenylalanine, hydrolyzed shellfish protein, beta-arbutin, ellagic acid, sodium ascorbate phosphate, carnosine, nicotinamide, inositol, papain and hesperidin extract. The whitening composition performs targeted inhibition from the melanin forming inducements of UV, inflammatory factors, melanoma and endothelin; in the melanin synthesis process, tyrosinase inhibits the reduction with a melanin intermediate, blocks the melanin transfer pathway, accelerates stratum corneum spalling and accelerates the metabolism; by conditioning, the skin is fine, tight, natural, white and bright.

The invention discloses an active polypeptide and tyrosinase inhibitor composition for whitening and freckle removal. The composition comprises polypeptides with a melanogenesis inhibition function and/or polypeptides with a glycosylation resistance function, and other components with a tyrosinase activity inhibition function. The composition is capable of inhibiting melanogenesis, resisting glycosylation, eliminating saccharified dark yellow proteins and eliminating in-vivo free radicals, so as to achieve the aims of improving the skin types, whitening and removing freckles.

The invention discloses a whitening black-removing compound which contains the following components by weight percent: 1-10% of nicotinamide, 1-5% of licochalcone A, 1-10% of arbutin, 0.5-1.5% of bletilla root extract, 0.5-1.5% of atractylodes root extract, 0.05-0.3% of pearl extract, 0.05-0.3% of ginseng extract, 0.01-0.5% of nymphaea alba flower, 0.01-0.5% of ligusticum root, 20-40% of glyceroland the balance of water. The whitening black-removing compound is capable of whitening and removing black at three aspects of melanin synthesis, transferring and removing, so that the whitening effect can be greatly promoted.

The present invention relates to skin care compositions comprising blends of camellia and feverfew serum fractions and/or kelp and parsley serum fractions. The skin care compositions also comprise a dermatologically acceptable carrier. The invention also relates to methods for increasing melanin production in skin by topically applying the skin care composition to areas in order to stimulate one or more steps in melanin synthesis and/or interrupt an inflammatory cycle.

The invention relates to a preparation method for paper mulberry fruit extracts and application of the paper mulberry fruit extracts in skin whitening. The preparation method comprises the following steps: taking paper mulberry fruit, adding an organic solvent (ethanol) 5 to 30 times the weight of the paper mulberry fruit, carrying out reflux extraction at a temperature of 50 to 100 DEG C for 1 to 10 h and standing, filtering and concentrating an obtained liquid extract so as to obtain a crude paper mulberry fruit concrete; and dispersing the concrete with water, carrying out separation and purification with a macroporous adsorption resin column and subjecting obtained eluates to condensation and drying so as to obtain the paper mulberry fruit extracts from different parts. The extracts are used for inhibiting activity of tyrosinase and synthesis of melanin and preparation of externally applied compositions for skin whitening, and the usage amount of the extracts is 0.01 to 15% by mass. The invention has the following advantages: according to results of a variety of skin whitening efficacy tests, the paper mulberry fruit extracts have a powerful effect on inhibiting activity of tyrosinase and synthesis of melanin, can be used for preparation of in-vitro skin whitening cosmetics and externally applied pharmaceuticals and have high security and good whitening effects.

The invention discloses a Chinese medicine extract composition with a whitening skin care function and application of the Chinese medicine extract composition. The medicine extract composition is prepared by compounding a grape seed extract, a shatian pomelo seed extract, a glycyrrhiza glabra extract, a white muscardine silkworm extract, a Szechuan lovage rhizome extract, a litchi pericarp extract, a spina date seed extract and a chickpea extract. The Chinese medicine extract composition can be used for whitening skin care cosmetics, can effectively inhibit tyrosinase activity and melanin synthesis, has effects of eliminating free radicals and resisting ultraviolet rays, and is a safe and high-efficiency whitening skin care agent.

Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.

The invention relates to application of a combination of polypeptide conjugates and epidermal stem cell exosomes in medicine and cosmetics. According to the present invention, exosomes are extracted and obtained from epidermal stem cells, the exosomes and polypeptide conjugates are prepared into a composition that inhibits melanin synthesis, and at the same time, skin experiments prove that the composition has the effects of removing freckles and preventing acne.

The invention provides applications of a biological active peptide with melanin synthesis inhibition activity in skin whitening, and belongs to the technical field of biological medicine and comestic.The amino acid sequence of the biological active peptide is represented by formula I: X1-(Gly-L-Gys)n-X2-X3 (I), wherein X1 is used for representing nothing or L-Phe, X2 is used for representing nothing or Gly, X3 is used for representing nothing or L-Phe, X1 and X3 are not used for representing nothing at the same time, and n is equal to or smaller than 8. The biological active peptide is capable of penetrating epidermis, entering corium layer, penetrating cell membrane, and entering cells, and is hydrolyzed into corresponding glycine and cysteine under the effect of hydrolase in cells, so that tyrosinase is inhibited, synthesis of melanin is inhibited, and effective skin whitening is achieved. The biological active peptide can be used for preparing a plurality of preparations used for preventing and treating human body chromatosis diseases and melanoma caused by excess melanin, and other preparations used for inhibiting the activity of tyrosinase.

The invention discloses an elsholtzia ciliata hyland extract, a preparation and an application thereof. The elsholtzia ciliata hyland extract is prepared by virtue of water extraction, has the effects of remarkably resisting free radicals, oxidation and radiation, resisting and inhibiting bacteria, promoting skin cell proliferation, protecting skin from ultraviolet injury and preventing skin from oxidation injury. By virtue of the characteristics, the elsholtzia ciliata hyland extract has the functions of preventing oxidation injury of skin, reducing melanin synthesis and delaying skin senescence, and has remarkable effects of allergy and senescence resistance when being applied to cosmetics.

The invention discloses application of conic gymnadenia rhizome in inhibiting the synthesis of skin melanin. The conic gymnadenia rhizome has an effective inhibiting function for tyrosinase, inhibitsthe generation of the melanin and achieves the effects of whitening faces and removing spots.

The invention provides a conjugate for inhibiting melanin synthesis, and shows a good inhibition activity for tyrosinase. Meanwhile, after the conjugate is prepared into the cosmetics, the cosmetics do not irritate skins and have a good whitening function.

The invention provides a composition for inhibiting melanin synthesis. The composition comprises an active ingredient (trans-dibydromorin) and solvents.

The invention discloses a CHMM1 culture medium suitable for in-vitro culture of Chinese epidermal melanocytes. The CHMM1 culture medium takes a base culture medium suitable for in-vitro culture of the epidermal melanocytes as a matrix, wherein the matrix is added with the following components: (1) serum with the volume concentration of 5%-20%, (2) 1-100 ng/mL of bFGF and 1-100 ng/mL of GM-CSF, and (3) 1-100 [mu]g/mL of 3-isobutyl-1-methylxanthine (IBMX) and 3-3000 ng/mL of alpha-MSH. The invention provides the culture medium suitable for in-vitro culture of the Chinese epidermal melanocytes, and the culture medium can be used for culture of the epidermal melanocytes having strengthened proliferation and melanin synthesis abilities, so that the epidermal melanocytes are better applied in transplantation treatment of skin disease patients with hypopigmentation or no pigments.