197 results about "Melanin synthesis" patented technology

The invention discloses a multi-effect repair type collagen and application thereof, and belongs to the technical field of synthetic biology. Transdermal peptide TD-1, a transmembrane region of human XVII type collagen, an extracellular sixteenth non-collagen region, an extracellular fifteenth collagen region and a coding gene of a His tag are selected to be connected in series, and a gene sequence is optimized through pichia pastoris codon selection preference; and then the T-COL17R3 is constructed and expressed to obtain the T-COL17R3. Efficacy experiments prove that compared with similar products sold in the market, T-COL17R3 not only has excellent transdermal performance, but also has better cell proliferation and migration promoting capability, better capability of resisting early saccharification product ketoamine and later saccharification product dicarbonyl compounds, better capability of scavenging free radicals and resisting elastase, and can be used for preparing the anti-epidermal drug. In addition, synthesis of melanin in B16-F10 cells can be reduced, so that T-COL17R3 has excellent application potential in development of pharmaceutical compositions or skin care products with repairing, anti-wrinkle and firming or whitening and brightening effects.

The invention provides a whitening composition, a whitening product, a preparation method and application. The invention provides application of the milk exosome and nicotinamide in improving the autophagy ability of tranexamic acid activated melanocytes. The whitening composition provided by the invention is prepared from the following components in parts by weight: 1 to 50 parts of milk exosome, 5 to 40 parts of tranexamic acid and 0.5 to 30 parts of nicotinamide. The provided whitening composition is an active composition capable of activating the autophagy function of melanocytes of a human body, melanin synthesis in the melanocytes can be reduced by inducing generation of autophagy-related protein and activating an autophagy system, dullness of the skin is improved, the skin color is brightened through an internal channel, and the product is free of irritation and high in safety.

The invention relates to a skin care composition containing white truffle and plant exosome and application thereof. The skin care composition containing white truffle and plant exosome comprises white truffle extract, chlorella exosome, DNA sodium, superoxide dismutase and fermentation product filtrate, the fermentation product filtrate comprises any one or a combination of at least two of lactobacillus / soybean milk fermentation product filtrate, lactobacillus / mung bean seed extract / sodium glutamate fermentation product filtrate, bifidobacterium fermentation product filtrate or saccharomycetes / rice fermentation product filtrate. According to the invention, the white truffle extract, the chlorella exosome, the DNA sodium, the superoxide dismutase and the fermentation product filtrate are creatively combined, and the composition has unexpected synergistic interaction in the aspects of inhibiting melanin synthesis, accelerating melanin metabolism and resisting oxidation and aging. The composition is mild in performance and free of irritation and toxic and side effects, and can be applied to cosmetic products more safely.

The invention discloses a high-transdermal recombinant humanized XVII type collagen as well as a preparation method and application thereof, and belongs to the technical field of synthetic biology. According to the preparation method, transdermal peptide TD-1, different functional fragments of human XVII type collagen and coding genes of His tags are selected to be connected in series, gene sequences are optimized through pichia pastoris codon selection preference firstly, and then the high-transdermal recombinant humanized XVII type collagen is obtained; and then the recombinant humanized XVII type collagen T-COL17-NC16 and the recombinant humanized XVII type collagen T-COL17 are constructed by expression of the recombinant humanized XVII type collagen T-COL17. Effect experiments prove that compared with similar products sold in the market, the skin-care product has more excellent transdermal performance, can improve cell proliferation and migration ability, also has obvious ability of resisting early saccharification product ketoamine and late saccharification product dicarbonyl compounds, better ability of scavenging free radicals and resisting elastase, and can be used for preparing the skin-care product. Moreover, synthesis of melanin in B16-F10 cells can be reduced, and the compound is expected to become a novel functional biological raw material to be applied to the fields of pharmaceutical compositions or skin care products and the like.

The invention relates to the field of cosmetics, in particular to sea rice fermentation filtrate, a preparation method thereof and a whitening cosmetic. Inoculating the first fermentation seed solution and the second fermentation seed solution into a fermentation culture medium, fermenting at 25-30 DEG C to obtain a fermentation product, and removing thalli in the fermentation product; the fermentation culture medium is prepared from the following components in percentage by mass: 5 to 10 percent of sea rice powder, 1 to 5 percent of saccharides and the balance of water; the pH value of the fermentation culture medium is 4-5; the first fermentation seed solution is a saccharomyces cerevisiae strain fermentation seed solution; the second fermentation seed solution is a lactobacillus plantarum strain fermentation seed solution. The method can promote the growth of saccharomyces cerevisiae and lactobacillus plantarum while promoting the release of an active component phytic acid in the sea rice, and has a remarkable effect of removing excessive free radicals and inhibiting the activity of related enzymes for synthesizing melanin; therefore, the whitening effect of the cosmetic can be effectively improved.

The invention relates to a skin care composition containing perigord truffle and plant exosome and application of the skin care composition. The skin care composition containing perigord truffle and plant exosome comprises perigord truffle extract, chlorella exosome, malachite extract, fermentation product filtrate and soluble collagen. The fermentation product filtrate comprises any one or a combination of at least two of a Thermus thermophilus fermentation product, a lactobacillus / soybean milk fermentation product filtrate or a lactobacillus / mung bean seed extract / sodium glutamate fermentation product filtrate. The perigord truffle extract, the chlorella exosome, the malachite extract, the fermentation product filtrate and the soluble collagen are creatively combined to form the composition with the whitening, anti-allergy and anti-oxidation effects, and the composition has the effects of inhibiting melanin synthesis, relieving skin inflammation response, whitening skin, resisting allergy and resisting oxidation. And an unexpected synergistic effect is achieved in the aspects of oxidation resistance and aging resistance. The composition is mild in performance and free of irritation and toxic and side effects, and can be applied to cosmetic products more safely.

The invention discloses a pyramid type thermal assembly efficacy skin care nanoparticle based on DNA nucleic acid and application thereof. According to the invention, skin-care active components are loaded into a nucleic acid framework in a thermal assembly innovation mode to obtain a'pyramid-shaped 'functional skin-care nano system, and the embedding rate, stability, infiltration capacity and bioavailability of the system are improved. According to the invention, four sections of nucleotide single chains with the length of 59 basic groups are designed as a tetrahedral framework sequence, so that the synthesis cost is reduced. According to the invention, a blending autonomous thermal assembly mode is developed to load skin-care active substances into a tetrahedral frame to prepare a'pyramid-shaped 'functional skin-care nano system, so that the embedding efficiency of the skin-care active substances is improved. Whitening active substances are wrapped, zebra fish experiments prove that the pyramid-shaped functional skin care (whitening) nanoparticles can more remarkably inhibit melanin synthesis and relieve and improve skin melanin pigmentation, and meanwhile, the system is proved to have a functional skin care effect.

The application discloses a whitening and freckle-removing composition, conditioner, medicine and cosmetic. The whitening and freckle-removing composition comprises broccoli, ganoderma lucidum and inula japonica in the composition; the broccoli comprises broccoli raw materials and / or broccoli extract, the ganoderma lucidum comprises ganoderma lucidum raw materials and / or ganoderma lucidum extract, and the inula japonica comprises inula japonica raw materials and / or inula japonica extract. The application has significant synergistic activity by scientific compounding of the broccoli and the inula japonica, has significant inhibitory effect on tyrosinase activity, can inhibit the expression and function of the rate-limiting enzyme TYR in the melanin synthesis process, has significant whitening and freckle-removing activity, is safe and efficient, and can be applied to various conditioners, medicines and cosmetics.

The invention belongs to the field of shampoo, and discloses hair-blacking and alopecia-stopping Chinese herbal medicine shampoo and a preparation process thereof. The shampoo cream is prepared from the following raw materials in parts by weight: 10 parts of cacumen biotae, 10 parts of Chinese honey locust, 110 parts of soapberry, 6 parts of szechwan chinaberry fruit, 5 parts of lucid ganoderma, 5 parts of pine needle, 5 parts of eclipta, 5 parts of garden balsam stem, 5 parts of tea seed powder, 5 parts of rhizoma drynariae, 5 parts of glossy privet fruit, 5 parts of mulberry leaf, 4 parts of duckweed, 3 parts of polygonum multiflorum, 3 parts of angelica sinensis, 3 parts of tribulus terrestris and 2 parts of ginseng. The hair-loss-preventing and hair-growing shampoo has the comprehensive effects of preventing hair loss and growing hair, namely activating hair follicle activity, promoting hair cell proliferation and improving scalp microcirculation through the components such as the radix polygoni multiflori preparata and the cacumen biotae. The hair blackening and brightening agent contains eclipta, mulberry leaves and the like, can promote melanin synthesis, inhibit decomposition, repair damaged hair and enhance hair gloss. The effects of controlling oil, removing dandruff, relieving itching, resisting inflammation, nourishing and conditioning are achieved.

The invention relates to an anti-ultraviolet-damage composition and application thereof in sunscreen products, and the anti-ultraviolet-damage composition is prepared from the following raw materials in parts by weight: 5-8 parts of oxhide tea leaf extract, 3-7 parts of green alga extract, 1-4 parts of dogwood extract, 8-10 parts of sea-buckthorn extract, 2.5-4 parts of butyrospermum parkii butter and 5-8 parts of camellia oleosa seed oil. All the raw materials have a synergistic effect, and free radicals generated by ultraviolet induction are neutralized, so that oxidative stress is relieved, and skin cells are protected from being damaged; ultraviolet rays are absorbed and are prevented from penetrating through the skin, so that direct damage of the ultraviolet rays to the skin is reduced; the activity of tyrosinase is regulated or a melanin synthesis pathway is blocked, the accumulation of melanin is reduced, and the effects of preventing and improving stains, darkness and the like are achieved.

The present invention relates to a functional cosmetic composition comprising plant exosomes derived from ginseng as an active ingredient and a functional cosmetic containing the same. Ginseng exosomes have a bilipid layer structure and are rich in ginsenosides Rb1 and Rg1, which influence skin improvement and whitening. It has been proven that these powerful functional materials, ginsenosides Rb1 and Rg1, are absorbed in large quantities through ginseng exosomes into skin cells, enhance the synthesis of collagen and hyaluronic acid in skin cells, and have the efficacy of inhibiting melanin synthesis. Therefore, the ginseng exosomes rich in ginsenosides Rb1 and Rg1, presented in the present invention, can be beneficially used in functional cosmetic compositions for skin aging prevention, skin whitening, wrinkle improvement and skin cell regeneration.

The present invention relates to a functional cosmetic composition comprising plant exosome derived from ginseng as an active ingredient thereof and a functional cosmetic comprising the same. Ginseng efflux has a dual lipid layer structure and is rich in ginsenosides Rb1 and Rg1 that affect skin improvement and whitening. The powerful functional substances ginsenosides Rb1 and Rg1 have been proved to be massively absorbed into skin cells through ginseng exosomes, enhance the synthesis of collagen and hyaluronic acid in the skin cells, and have the efficacy of inhibiting melanin synthesis. Therefore, the ginseng exosome rich in ginsenosides Rb1 and Rg1, as presented in the present invention, can be advantageously used in a functional cosmetic composition for skin aging prevention, skin whitening, wrinkle reduction, and skin cell regeneration.

The invention provides a whitening composition suitable for sensitive skin staying up late. According to the present invention, the red, yellow and black skin color problem of people with sensitive skin staying up late is solved, and on the basis of inhibition of tyrosinase and inhibition of melanin synthesis, the anti-oxidation, anti-saccharification, inflammatory factor inhibition, skin rhythm regulation and other aspects are combined, such that skin erosion caused by the outside during the day is resisted, skin circadian rhythm is improved, and skin aging is inhibited. The composition effectively regulates and controls the damage of staying up late to the skin, improves the self-repairing ability of the skin at night, and forms an efficient whitening composition with daily prevention and night repairing synergistic whitening. Compared with a common whitening composition, the whitening composition is higher in whitening efficiency, and skin color problems such as red, yellow and black skin and the like are improved more comprehensively; the whitening composition provided by the invention is stable in property, is suitable for various types of cosmetic dosage forms, can be widely applied to various whitening cosmetics, and makes contributions to developing new fields related to skin whitening and expanding the market.

The invention discloses a whitening and freckle-removing composition, a conditioner, a medicine and a cosmetic. The whitening and freckle-removing composition is prepared from emblic leafflower fruit, passion fruit and Chinese ladiestresses root and leaf A; the phyllanthus emblica comprises a phyllanthus emblica raw material and / or a phyllanthus emblica extract, and the passion fruit comprises a passion fruit raw material and / or a passion fruit extract. Through scientific compatibility of the Chinese ladiestresses root-ginseng A and the second active component comprising one or more of the emblic leafflower fruit, the passion fruit and the salvia officinalis, the Chinese ladiestresses root-ginseng A has a remarkable inhibition effect on tyrosinase activity, can inhibit expression and functions of rate-limiting enzyme TYR in the melanin synthesis process, has a remarkable whitening and freckle-removing active effect, and has a remarkable whitening and freckle-removing effect. The composition is safe and efficient, and can be applied to various conditioners, medicines and cosmetics.

The invention discloses an active peptide with a whitening effect as well as a preparation method and application thereof, and belongs to the technical field of biological medicines and cosmetics. The amino acid sequence of the active peptide is shown as SEQ ID No.1-26, the active peptide has a good inhibition effect on melanin synthesis and tyrosinase activity, and the active peptide has whitening activity and application potential as a whitening product, has the advantages of being safe, effective, free of toxic and side effects, good in biocompatibility and the like, and has a wide application prospect.

The invention relates to the field of cosmetics, in particular to a natural plant whitening skin care product as well as a preparation method and a composition thereof. The composition comprises the following components in percentage by mass: a first functional component and a second functional component, and a substrate; the first functional component is prepared from 0.01 to 1 percent of ormosia henryi bark extract and 0.5 to 5 percent of humulus lupulus extract; the second functional component comprises 0.1-5% of a rosa roxburghii tratt fruit extract and 0.1-5% of a plantago major seed extract; the balance is the matrix. The skin care product does not contain phenylethyl resorcinol and arbutin. The plant extracts can be used as raw materials to achieve the whitening effect, the product is mild and suitable for sensitive people to use, and more importantly, starting from multiple dimensions of ultraviolet protection, melanin synthesis and transfer inhibition, inflammation resistance, oxidation resistance and the like at the same time, the faster and stronger whitening effect can be achieved through the combined action of multiple whitening mechanisms; the multi-mechanism and multi-dimensional whitening effect can be achieved, and the whitening effect is greatly improved.

The invention provides lactobacillus reuteri Ligh-alpha with whitening and anti-aging activity and related application thereof, and relates to the technical field of microorganisms and application thereof. The Lactobacillus reuteri Ligh-alpha is preserved in the General Microbiological Culture Collection Center of the China Committee for Culture Collection of Microorganisms on January 2, 2024, and the preservation number of the Lactobacillus reuteri Ligh-alpha is CGMCC No. 29488. The lactobacillus reuteri Ligh-alpha provided by the invention can be used for effectively inhibiting the activity of tyrosinase and reducing melanin synthesis; meanwhile, the Ligh-alpha strain also has excellent free radical scavenging ability and relatively high reducing power, shows very strong antioxidant ability, and can tolerate acid-base and cholate environments. Therefore, the Lactobacillus reuteri Ligh-alpha strain has a wide market application prospect in the aspect of preparing products for whitening, resisting oxidation, resisting aging and the like.

The invention discloses application of Bombyx mori neuropeptide BommoOKAtype4 in preparation of a medicine for inhibiting melanoma cell growth, and belongs to the technical field of medical biology. Aiming at the technical problems that melanoma is high in malignancy degree, easy to transfer and limited in treatment means, and whether the bombyx mori neuropeptide BommoOKAtype4 can directly inhibit the growth of melanoma cells is not clear yet when the bombyx mori neuropeptide BommoOKAtype4 is mainly used for skin whitening before, the invention provides the application of the bombyx mori neuropeptide in preparing the medicine for inhibiting the melanoma cells. According to the silkworm neuropeptide, gene expression and protein functions of melanin synthesis key enzymes TYR, TRP1 and TRP2 are comprehensively inhibited by down-regulating expression of a core transcription factor MITF, so that melanoma cell proliferation is directly inhibited while melanin synthesis is inhibited, and therefore, the silkworm neuropeptide can be used for preparing drugs for treating melanoma and has a wide application prospect. A novel peptide candidate substance is provided for treatment of melanoma.

The peptides of the present invention exhibit skin whitening activity by inhibiting melanin synthesis in melanocytes and inhibiting melanin body migration. Therefore, the peptide of the present invention can be used as an active ingredient in a medicament for treating or preventing hyperpigmentation diseases caused by excessive deposition of melanin bodies, or as an active ingredient in a cosmetic for skin whitening.

This invention discloses the use of ONO-2952 or a pharmaceutically acceptable salt thereof in the preparation of drugs / cosmetics for treating and / or preventing hyperpigmentation disorders, belonging to the field of pharmaceutical technology. ONO-2952 of this invention inhibits melanin synthesis induced by endogenous factors α-MSH, ACTH, and UVB radiation, thereby inhibiting melanin synthesis by suppressing the expression of key melanin synthesis proteins MITF and Tyrosinase in melanocytes. Therefore, ONO-2952 or a pharmaceutically acceptable salt thereof can be used in the preparation of drugs / cosmetics for treating and / or preventing hyperpigmentation disorders.

This invention relates to the cosmetic use of a composition for improving gray hair. The composition of this invention promotes melanin synthesis in hair by activating the Wnt / β-catenin signaling pathway, thereby exhibiting significant and excellent effects in inhibiting, preventing, improving, alleviating, delaying, or treating gray hair (white hair syndrome).

A whitening composition containing the following components: Mori folium, Panacis quinquefolii radix, (-)-podophyllotoxin, and (+)-glaucarubinone. Further provided is the use of the whitening composition in the preparation of a product for whitening the skin, or a product for inhibiting melanin synthesis, or a product for improving skin pigmentation.

The invention discloses jellyfish polypeptide with tyrosinase inhibitory activity and application of the jellyfish polypeptide, and belongs to the technical field of biology. A jellyfish crude polypeptide is prepared, a jellyfish polypeptide GEPINPEAWLWYYKYVG is identified and optimized from the jellyfish crude polypeptide, and experiments prove that the jellyfish polypeptide provided by the invention can inhibit the activity of tyrosinase in vitro, can inhibit melanin secretion of B16-F10 mouse melanoma cells, and can inhibit the activity of tyrosinase in the cells. Therefore, the jellyfish polypeptide can be used as a tyrosinase inhibitor and an anti-melanin synthesis agent and is applied to the fields of cosmetics, medical treatment and the like. Experiments prove that the jellyfish polypeptide provided by the invention has no cytotoxicity, is derived from ocean, and has no disease risks and religious barriers of terrestrial animals.

The invention relates to the technical field of cosmetics, in particular to a compound active peptide with functions of resisting aging and whitening skin and application of the compound active peptide. Comprising acetyl hexapeptide-1, nonapeptide-1, acetyl tetrapeptide-11, hexapeptide-9 and palmitoyl hexapeptide-12. The compound peptide disclosed by the invention can play a synergistic anti-aging and whitening role on an epidermal layer and a corium layer, and has multiple advantages; the compound peptide acts on epidermal layer keratinocytes, dermal layer fibroblasts and B16F10 cells, and can be used for detecting the senescence of the cells by influencing the expression quantity of cell senescence marker genes, influencing the cell cycle, influencing the expression quantity of extracellular matrix related proteins, influencing melanin synthesis and influencing the secretion quantity of acetylcholine in the cells. Multiple skin anti-aging and whitening effects synergistically exerted on the epidermal layer and the corium layer are achieved.

The invention discloses application of rifudine in preparation of a preparation for promoting cell melanin synthesis, and belongs to the technical field of special drugs. The invention provides a new application of rifudine, which can promote synthesis and secretion of melanin and expression of TYR, TRP-1 and TRP-2, provides a new functional component for enhancing synthesis of melanin in vivo and preparing products for treating vitiligo and the like, and has a wide application prospect in the fields of pharmaceutical preparations, cosmetics, care products, beauty products and the like.

The application belongs to the technical field of biological materials, and specifically discloses an amino acid whitening polypeptide and a preparation method thereof. The structural general formula of the polypeptide is as follows: R-A-B-NH2, wherein R is a modified acyl group serving as an N terminal and having a carbon number ranging from 6 to 10, A is D-proline and a derivative thereof, and B is D-arginine and a derivative thereof. The amino whitening polypeptide is prepared by using an Fmoc solid-phase synthesis method. The whitening polypeptide has excellent melanin synthesis inhibition activity, and plays a role by targeting inhibition of TRP-1. At a concentration of 1 μM, the melanin synthesis inhibition rate of B16 cells reaches a statistically significant standard, which is significantly better than a conventional whitening agent that can only achieve a similar inhibition effect at a high concentration, and greatly reduces the effective use concentration of a whitening product.

The invention relates to the technical field of skin care products, in particular to a turnip extracting solution and a preparation method and application thereof. The preparation method comprises the following steps: mixing turnip with water, decocting to obtain a decoction, decolorizing, filtering and concentrating to obtain the turnip extracting solution. The turnip extracting solution is used for effectively inhibiting B16 cells from generating melanin and inhibiting the activity of tyrosinase in a melanin synthesis path; the increase of the active oxygen level in HaCaT cells is effectively prevented, and the antioxidant effect is obvious; the inflammation of the SDS surfactant on HaCaT cells is effectively prevented, and the generation of an inflammatory factor TNF-alpha is reduced; the expression of cell natural moisturizing factors, ceramide de novo synthesis rate-limiting enzymes and epidermal barrier related genes is up-regulated; the composition can effectively promote the generation of cell collagen and elastin, reduces the synthesis of matrix metalloproteinase 1 for degrading collagen under ultraviolet radiation, and has an anti-aging effect.

The present application relates to a kind of anti-ultraviolet damage composition and its application in sunscreen product, the anti-ultraviolet damage composition includes the following raw materials by weight parts: 5-8 parts of daphne giraldii leaf extract, 3-7 parts of green algae extract, 1-4 parts of dogwood extract, 8-10 parts of sea buckthorn extract, 2.5-4 parts of avocado butter and 5-8 parts of tea seed oil, each raw material has synergistic effect, by neutralizing the free radical induced by ultraviolet, reduce oxidative stress, protect skin cells from damage;Absorb ultraviolet, reduce the penetration of ultraviolet through skin, thereby reducing the direct damage of ultraviolet to skin;Regulate tyrosinase activity or block the melanin synthesis pathway, reduce the accumulation of melanin, help to prevent and improve the efficacy of anti-ultraviolet damage such as pigmentation, dull and other ways.

The present invention provides a cosmetic composition for skin whitening, comprising a specific peptide. The peptide acts as an antagonist for β-catenin, thereby effectively inhibiting β-catenin signaling as well as inhibiting tyrosinase expression and melanin synthesis. As a result, the peptide can be effectively used for skin whitening.

The invention relates to the technical field of biology. The invention discloses a strain bacillus sp. JX-7, and the preservation number of the strain bacillus sp. JX-7 is CGMCC (China General Microbiological Culture Collection Center) No.27978. The preservation date of the strain is July 24, 2023, the preservation unit is China General Microbiological Culture Collection Center, the China General Microbiological Culture Collection Center is called CGMCC for short, and the address of the China General Microbiological Culture Collection Center is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The bacillus sp. JX-7 provided by the invention can be used for effectively increasing the content of organic carbon in soil and has efficient melanin synthesis capability.