Hair-blacking and alopecia-stopping Chinese herbal medicine shampoo cream and preparation process thereof

Abstract

The invention belongs to the field of shampoo, and discloses hair-blacking and alopecia-stopping Chinese herbal medicine shampoo and a preparation process thereof. The shampoo cream is prepared from the following raw materials in parts by weight: 10 parts of cacumen biotae, 10 parts of Chinese honey locust, 110 parts of soapberry, 6 parts of szechwan chinaberry fruit, 5 parts of lucid ganoderma, 5 parts of pine needle, 5 parts of eclipta, 5 parts of garden balsam stem, 5 parts of tea seed powder, 5 parts of rhizoma drynariae, 5 parts of glossy privet fruit, 5 parts of mulberry leaf, 4 parts of duckweed, 3 parts of polygonum multiflorum, 3 parts of angelica sinensis, 3 parts of tribulus terrestris and 2 parts of ginseng. The hair-loss-preventing and hair-growing shampoo has the comprehensive effects of preventing hair loss and growing hair, namely activating hair follicle activity, promoting hair cell proliferation and improving scalp microcirculation through the components such as the radix polygoni multiflori preparata and the cacumen biotae. The hair blackening and brightening agent contains eclipta, mulberry leaves and the like, can promote melanin synthesis, inhibit decomposition, repair damaged hair and enhance hair gloss. The effects of controlling oil, removing dandruff, relieving itching, resisting inflammation, nourishing and conditioning are achieved.

Description

Technical Field

[0001] The present invention belongs to the technical field of hair shampoo, and particularly relates to a Chinese herbal medicine hair shampoo for blackening hair and preventing hair loss and its preparation process. Background Art

[0002] Due to factors such as modern life pressure, environmental pollution, and irregular work and rest, the number of people with hair loss and white hair has increased significantly. Especially in the youth group, there are premature hair loss and premature whitening of hair and beard. Traditional hair blackening and anti-hair loss products rely on chemical components that degrease or stimulate hair follicles, and long-term use may cause damage to the scalp barrier or dependence. More and more people tend to choose natural hair care products without chemical additives to avoid scalp irritation or side effects that may be caused by long-term use of chemically synthesized components. However, some current hair shampoos have problems such as poor water solubility, easy decomposition, or low compatibility of Chinese herbal medicine active ingredients (such as apigenin and procyanidin B2), which affect the product effect.

[0003] Based on this, the applicant has developed a Chinese herbal medicine hair shampoo for blackening hair and preventing hair loss. Summary of the Invention

[0004] To overcome the above technical problems, the present invention provides a Chinese herbal medicine hair shampoo for blackening hair and preventing hair loss and its preparation process.

[0005] The present invention adopts the following technical solutions: The Chinese herbal medicine hair shampoo for blackening hair and preventing hair loss is made from the following raw materials in parts by weight: 10 parts of Platycladus orientalis leaves, 10 parts of Chinese honey locust, 110 parts of Sapindus mukorossi, 6 parts of Melia toosendan, 5 parts of Ganoderma lucidum, 5 parts of Pinus massoniana needles, 5 parts of Eclipta prostrata, 5 parts of Speranskia tuberculata, 5 parts of tea seed powder, 5 parts of Drynaria fortunei, 5 parts of Glossy privet fruit, 5 parts of mulberry leaves, 4 parts of duckweed, 3 parts of Polygonum multiflorum, 3 parts of Angelica sinensis, 3 parts of Tribulus terrestris, and 2 parts of ginseng.

[0006] The preparation process of the above-mentioned Chinese herbal medicine hair shampoo for blackening hair and preventing hair loss includes the following steps: S1. Pretreatment of raw materials Remove impurities from all dried Chinese herbal medicines such as Angelica sinensis, Polygonum multiflorum, and Eclipta prostrata, quickly rinse with clear water to remove floating dust, and pulverize to 20-40 meshes after low-temperature drying (≤40°C); Separate and pulverize Chinese honey locust and Sapindus mukorossi into coarse particles for subsequent extraction of saponin components; S2. Extraction of active ingredients Extraction by water decoction Mix the Chinese herbal medicines except Chinese honey locust and Sapindus mukorossi, add pure water according to the solid-liquid ratio of 1:10, reflux and extract at 90°C for 2 hours, and filter; repeat the extraction of the medicinal residues once, and combine the filtrates; Special extraction of saponins Extract Chinese honey locust and Sapindus mukorossi separately with 70% ethanol (solid-liquid ratio 1:8) by ultrasonic extraction at 60°C for 1 hour, filter and concentrate until the alcohol smell disappears; Concentration and mixing Combine the water extract and the alcohol extract, and concentrate under reduced pressure to an extract with a relative density of 1.1-1.2 (60°C) for later use; S3. Basic formula (mass percentage) Chinese herbal medicine extract: 15-20%, Amino acid surfactant (sodium cocoyl glycinate): 10%, Glycerin (moisturizing): 5%, Thickener (xanthan gum): 0.8%, Preservatives (phenoxyethanol + ethylhexylglycerin): 0.6%, pH adjuster (citric acid): adjust to 5.5-6.0, Deionized water: make up to 100%; S4. Dissolution and homogenization Pre-disperse xanthan gum in glycerol, add 60°C deionized water and stir to dissolve; add surfactant and Chinese herbal medicine extract in sequence, and mix with a homogenizer at 3000rpm for 15 minutes; S5. pH adjustment and preservation Cool down to below 40℃, add preservatives, and adjust pH to weak acid with citric acid; S6. Filling After filtration (200 mesh screen), vacuum degassing and aseptic filling.

[0007] 0.1% vitamin E is added during the concentration stage to prevent oxidation of the ingredients.

[0008] Compared with the prior art, the present invention has the following beneficial effects: 1. Core anti-hair loss and hair growth effect Activate hair follicles Polygonum multiflorum contains lecithin and anthraquinones, which can promote the proliferation of hair matrix cells; total flavonoids from Platycladus orientalis leaves can improve scalp microcirculation and activate atrophic hair follicles; ginsenosides and Ganoderma lucidum polysaccharides can enhance the nutritional supply of hair follicles and delay the aging of hair follicles.

[0009] Hair loss prevention Eclipta prostrata and Ligustrum lucidum (combined with Erzhi Pills) protect hair follicles through antioxidant effects; Drynaria fortunei promotes scalp collagen synthesis and strengthens the adhesion of hair roots; pine needles contain quercetin, which can inhibit the production of DHT (an androgen metabolite that causes hair loss).

[0010] 2. Black and shiny hair The diphenylethylene glycosides in processed Polygonum multiflorum can activate tyrosinase activity and accelerate the production of melanin; mulberry leaf polyphenols inhibit the decomposition of melanin, and the copper contained in duckweed assists pigmentation.

[0011] Nutritional hair repair Angelica sinensis replenishes blood and promotes blood circulation, improves hair microcirculation, and enhances hair elasticity; Ganoderma lucidum polysaccharides repair damaged hair scales and enhance hair gloss.

[0012] 3. Scalp environment conditioning The natural saponin ingredients in soapberry and gleditsia can effectively remove oil and regulate sebum secretion; while herba scutellariae can inhibit the reproduction of Malassezia and reduce the formation of dandruff.

[0013] The flavonoids contained in duckweed can relieve scalp itching; the alkaloids in Toosendan have an inhibitory effect on seborrheic dermatitis; and the saponins in Tribulus terrestris can reduce allergic reactions of the scalp.

[0014] 4. Other auxiliary effects Natural cleaning system, soapberry and soapberry are combined to form mild foam, avoiding the irritation of chemical surfactants.

[0015] Antioxidant protection: oleanolic acid in Ligustrum lucidum and Eclipta prostrata can neutralize free radicals and delay the occurrence of gray hair. DETAILED DESCRIPTION

[0016] The embodiments of the present invention are described in detail below. Unless otherwise specified, the raw materials and equipment used can be purchased from the market or are commonly used in the art. The methods in the embodiments, unless otherwise specified, are conventional methods in the art. The embodiments described below are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0017] Prepare Chinese medicinal raw materials according to the following proportions: 10 parts of Platycladus orientalis leaves, 10 parts of Gleditsia sinensis, 110 parts of Sapindus mukorossi, 6 parts of Toosendan fruits, 5 parts of Ganoderma lucidum, 5 parts of pine needles, 5 parts of Eclipta prostrata, 5 parts of Radix schizonepetae, 5 parts of Camellia sinensis seed powder, 5 parts of Drynaria fortunei, 5 parts of Ligustrum lucidum fruits, 5 parts of mulberry leaves, 4 parts of duckweed, 3 parts of Polygonum multiflorum, 3 parts of Angelica sinensis, 3 parts of Tribulus terrestris, and 2 parts of ginseng.

[0018] S1. Raw material pretreatment Remove impurities from all dried Chinese herbal medicines such as Angelica sinensis, Polygonum multiflorum, and Eclipta prostrata, rinse quickly with clean water to remove floating dust, dry at low temperature (≤40℃), and then crush to 20-40 mesh; Gleditsia sinensis and Soapberry fruit are crushed into coarse particles separately to facilitate the subsequent extraction of saponin components; S2. Extraction of active ingredients Water decoction extraction Mix the Chinese herbal medicines except Gleditsia sinensis and Sapindus mukorossi, add pure water at a solid-liquid ratio of 1:10, reflux extract at 90°C for 2 hours, and filter; extract the residues repeatedly once, and combine the filtrates; Saponin special extraction Gleditsia sinensis and Soapberry were extracted with 70% ethanol (solid-liquid ratio 1:8) at 60°C for 1 hour by ultrasonic extraction, filtered and concentrated until there was no alcohol taste; Concentration and mixing Combine the water extract and the alcohol extract, and concentrate under reduced pressure to an extract with a relative density of 1.1-1.2 (60°C). Add 0.1% vitamin E during the concentration stage to prevent oxidation of the ingredients, and set aside. S3. Basic formula (mass percentage) Chinese herbal medicine extract: 15-20%, Amino acid surfactant (sodium cocoyl glycinate): 10%, Glycerin (moisturizing): 5%, Thickener (xanthan gum): 0.8%, Preservatives (phenoxyethanol + ethylhexylglycerin): 0.6%, pH adjuster (citric acid): adjust to 5.5-6.0, Deionized water: make up to 100%; S4. Dissolution and homogenization Pre-disperse xanthan gum in glycerol, add 60°C deionized water and stir to dissolve; add surfactant and Chinese herbal medicine extract in sequence, and mix with a homogenizer at 3000rpm for 15 minutes; S5. pH adjustment and preservation Cool down to below 40℃, add preservatives, and adjust pH to weak acid with citric acid; S6. Filling After filtration (200 mesh screen), vacuum degassing and aseptic filling.

[0019] Evaluation indicators and methods Anti-hair loss effect Hair loss count: record the number of hairs lost after washing (comparison at 0, 4, 8, and 12 weeks).

[0020] Hair density measurement: Observe the hair follicle density and the proportion of new hair by dermatoscope.

[0021] Hair follicle activity detection: Dermal papilla cells were extracted and the effect of shampoo cream extract on cell proliferation was evaluated by MTT method.

[0022] Dark hair effect Determination of hair shaft melanin content: Spectrophotometry was used to detect the changes in hair melanin concentration before and after use.

[0023] Tyrosinase activity analysis: In vitro experiments were used to verify the promoting effects of processed Polygonum multiflorum, Eclipta prostrata and other ingredients on melanin synthesis.

[0024] Anti-dandruff and anti-itching and scalp health AFSF scoring method: quantify the area of ​​dandruff (0-4 points) and the frequency of itching.

[0025] Malassezia detection: scalp sampling and culture, and statistical changes in colony counts.

[0026] Sebum secretion rate: Sebumeter was used to measure the sebum secretion in the T zone.

[0027] Safety Assessment Skin irritation test: The sensitization of the shampoo cream to the skin was evaluated by patch test (observation of erythema and edema for 48 hours).

[0028] Long-term tolerance: The incidence of adverse reactions such as dry scalp and tingling was recorded during the experiment.

[0029] 3. Experimental Methods Human clinical trials A double-blind randomized controlled design was used, with 30 people in each experimental group and control group, and a unified washing and care process (water temperature 37°C, massage for 5 minutes).

[0030] A standardized questionnaire was used to collect the subjects' subjective feelings (such as hair smoothness and scalp freshness).

[0031] In vitro experiments Antibacterial experiment: Test the inhibition rate of shampoo against Staphylococcus aureus and Malassezia (agar diffusion method).

[0032] Antioxidant capacity: The antioxidant activity of ingredients such as Platycladus orientalis leaves and pine needles was evaluated by DPPH free radical scavenging rate.

[0033] Molecular mechanism research RT-PCR detection: Analyze the expression levels of hair follicle-related genes such as β-catenin and VEGF.

[0034] Hormone level monitoring: Collect blood samples to test DHT (dihydrotestosterone) concentration and verify the 5α-reductase inhibitory effect of ingredients such as pine needles.

[0035] 4. Data Analysis and Conclusion Statistical methods SPSS software was used for t-test and ANOVA analysis, with a significance threshold of P<0.05.

[0036] result The amount of hair loss in the experimental group was reduced by ≥40%, and the density of new hair increased by 30%-50%.

[0037] The dandruff area score decreased by ≥2 points and the Malassezia inhibition rate was >80%.

[0038] Melanin content increased by 20%-30%, and tyrosinase activity was significantly enhanced.

[0039] The development of the Chinese herbal shampoo for blackening hair and stopping hair loss is the result of the combined effects of market demand, scientificization of traditional medicine and technological breakthroughs. Its core goal is to provide a safe and long-lasting solution through the combination of natural ingredients and modern technology, while meeting consumers' dual needs for efficacy and experience. In the future, with the in-depth research on the active ingredients of Chinese herbal medicines and the advancement of formulation technology, such products are expected to be further optimized and their application scope expanded.

[0040] Although the embodiments of the present invention have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the above embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. A Chinese herbal shampoo cream for darkening hair and preventing hair loss, characterized in that: The invention is prepared from the following raw materials in parts by weight: 10 parts of Platycladus orientalis leaves, 10 parts of Gleditsia sinensis, 10 parts of Sapindus mukorossi, 6 parts of Toosendan fruits, 5 parts of Ganoderma lucidum, 5 parts of pine needles, 5 parts of Eclipta prostrata, 5 parts of Radix schizonepetae, 5 parts of Camellia sinensis seed powder, 5 parts of Drynaria fortunei, 5 parts of Ligustrum lucidum fruits, 5 parts of mulberry leaves, 4 parts of duckweed, 3 parts of Polygonum multiflorum, 3 parts of Angelica sinensis, 3 parts of Tribulus terrestris and 2 parts of ginseng.

2. The preparation process of the Chinese herbal shampoo cream for darkening hair and preventing hair loss according to claim 1, characterized in that: The following steps are involved: S1. Raw material pretreatment Remove impurities from all dried Chinese herbal medicines such as Angelica sinensis, Polygonum multiflorum, and Eclipta prostrata, quickly rinse with clean water to remove floating dust, dry at low temperature (≤40°C), and then crush to 20-40 mesh; crush Gleditsia sinensis and Sapindus mukorossi separately to coarse particles to facilitate the subsequent extraction of saponin components; S2. Extraction of active ingredients Water decoction extraction: Mix the Chinese herbal medicines except Gleditsia sinensis and Soapberry, add pure water at a solid-liquid ratio of 1:10, reflux extraction at 90℃ for 2 hours, and filter; Repeat the extraction of the residue once, and combine the filtrate; Special extraction of saponin: Gleditsia sinensis and Soapberry are extracted with 70% ethanol (solid-liquid ratio 1:8) at 60℃ for 1 hour, filtered and concentrated until there is no alcohol taste; Concentration and mixing: Combine the water extract and the alcohol extract, and concentrate under reduced pressure to an extract with a relative density of 1.1-1.2 (60℃), and set aside; S3. Basic formula (mass percentage) Chinese herbal medicine extract: 15-20%; amino acid surfactant (sodium cocoyl glycinate): 10%; glycerin (moisturizing): 5%; thickener (xanthan gum): 0.8%; preservative (phenoxyethanol + ethylhexylglycerin): 0.6%; pH adjuster (citric acid): adjust to 5.5-6.0; deionized water: make up to 100%; S4. Dissolution and homogenization Pre-disperse xanthan gum in glycerol, add 60°C deionized water and stir to dissolve; add surfactant and Chinese herbal medicine extract in sequence, and mix with a homogenizer at 3000rpm for 15 minutes; S5. pH adjustment and preservation Cool down to below 40℃, add preservatives, and adjust pH to weak acid with citric acid; S6. Filling After filtration (200 mesh screen), vacuum degassing and aseptic filling.

3. The preparation process of the Chinese herbal shampoo cream for blackening hair and preventing hair loss according to claim 2, characterized in that: 0.1% vitamin E is added during the concentration stage to prevent oxidation of the ingredients.