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Dyer's woad root vitamin C fizzy formulation

An effervescent preparation, the technology of Banlangen, which is applied in the direction of pill delivery, medical preparations containing active ingredients, and medical raw materials derived from angiosperm submenus, can solve problems such as synergistic effects that have not yet been seen, and achieve controllable methods and effervescent The effect of short time and high effective content

Inactive Publication Date: 2008-05-21
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vitamin C is already a well-known good medicine for preventing colds and improving human immunity. So far, there has been no report about using the two at the same time as a medicine to produce a synergistic effect and better efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 optimization, screening experiment

[0023] 1. Screening of acid sources for effervescent preparations:

[0024] Select three kinds of acid sources, through the investigation of their properties and phenomena, the results show that citric acid monohydrate is a hydrate containing crystal water, the phenomenon of moisture absorption is improved, and the phenomenon of sticking is less, and citric acid monohydrate is more Good acid source.

[0025] Table 1 is the acid source screening results table.

[0026] Table 1

[0027] acid source

nature

Phenomenon

anhydrous citric acid

Citric acid monohydrate

tartaric acid

tribasic acid

Tribasic acid with water of crystallization

Tribasic acid, stronger acidity than the above two acids

Severe sticky punch

Basic non-stick punch

Relatively sticky

[0028] 2. Screening of fillers for effervescent preparations:

[0029] Select three fillers: ...

Embodiment 2

[0096] Embodiment 2: Isatis Radix Vitamin C effervescent tablet is prepared according to the following prescription ratio and preparation process: prescription: (1000 tablets)

[0097] Banlangen extract powder 600g

[0098] Vitamin C 25g

[0099] Lactose 321g

[0100] Xylitol 321g

[0101] Citric Acid Monohydrate 1800g

[0102] Sodium bicarbonate 1100g

[0103] Leucine 86g

[0104] Aspartame 60g

[0105] Orange Flavor 186g

[0106] Pigment 1g

[0107] Preparation of Banlangen Vitamin C Effervescent Preparation:

[0108] 1. The preparation of Radix Radix Radix extract powder, its step is mainly as follows: (1) select Radix Radix Radix medicinal material, wash, remove impurity back for subsequent use; Boil 10 times the water for 2 hours, stop heating, keep the extract at 80°C for 1 hour, decoct 3 times, each time for 1 hour, and filter; (3) The filtrate is allowed to stand overnight, and the supernatant is centrifuged and concentrated to a relative density of 1.0-1.2 (...

Embodiment 3

[0111] Banlangen vitamin C effervescent tablets are prepared according to the following prescription ratio and preparation process:

[0112] Prescription: (1000 tablets)

[0113] Banlangen extract powder 600g

[0114] Vitamin C 25g

[0115] Lactose 321g

[0116] Xylitol 321g

[0117] Citric Acid Monohydrate 1800g

[0118] Sodium bicarbonate 1100g

[0119] Leucine 86g

[0120] Aspartame 60g

[0121] Orange Flavor 186g

[0122] Pigment 1g

[0123] Preparation of Banlangen Vitamin C Effervescent Preparation:

[0124] 1. the preparation technology of Radix Radix Radix Radix Extract powder, its step: with embodiment 2

[0125]2. Preparation of Radix Isatidis Vitamin C Effervescent Tablets: (1) Extract and dry Radix Isatidis medicinal material, obtain extract powder and store in airtight until use; (2) Grind extract powder and vitamin C through a 100-mesh sieve respectively, Store in airtight until use; Grind lactose, xylitol, sodium bicarbonate, and leucine separately, p...

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Abstract

The invention belongs to the field of chemical pharmacy, and in particular relates to an effervescent preparation of isatidis vitamin C and a preparation method thereof. The invention is prepared by adding Radix Radix Radix Extract Powder and vitamin C with auxiliary materials such as acid, alkali, filler, flavoring agent and lubricant. Through optimization and screening, the present invention determines the reasonable ratio of the main drug, auxiliary materials and disintegrants. The preparation has strong stability, high effective content, short effervescent time, and the liquid medicine after effervescence has good clarity and taste. Well, the preparation process of the present invention is simple, the method is controllable, and the quality is stable. The effervescent tablet of the present invention can be compressed into a large round plain tablet or coated with a film, or compressed into a special-shaped tablet or a slow-controlled effervescent preparation. It is proved by experiments that the preparation of the invention can significantly increase the solubility of the drug, has good solubility, can be better absorbed by the human body, and has good market development prospects.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy, and in particular relates to an effervescent preparation of isatidis vitamin C and a preparation method thereof. Background technique [0002] An effervescent preparation is a pharmaceutical dosage form containing an effervescent disintegrant. The so-called effervescent disintegrant refers to the mixture of alkaline agent (such as: sodium bicarbonate) and acid agent (such as: organic acids such as citric acid) in pairs. When it meets water, the two react to produce a large amount of carbon dioxide gas, so that Tablets disintegrate rapidly. When applying, put the tablet into a water glass to disintegrate quickly and drink it. At present, there are many types of effervescent preparations on the market, but most of them are imported products. Oral effervescent preparations are dominated by vitamin effervescent preparations, and there are external gynecological effervescent preparations, such as Ji...

Claims

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Application Information

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IPC IPC(8): A61K36/19A61K36/315A61K9/16A61K9/20A61K9/46A61P11/04A61P31/00A61P37/04A61K31/375
Inventor 王建新施雯韩丽妹陈国锋
Owner FUDAN UNIV
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