Process for synthesizing clindamycin phosphate
A technology of clindamycin phosphate and synthesis process, which is applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve the problems of high pressure, high pyridine price and high production cost, and achieves simple process method and high yield rate, the effect of reducing the pressure of discharge
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Embodiment 1
[0014] 3.4-Synthesis of Clindamycin Condensate (Protect)
[0015] (1) Take 40Kg, 150Kg, and 25Kg of clindamycin hydrochloride alcoholate, acetone, and phosphorus oxychloride respectively, mix the above three substances, and react with heat preservation and stirring for 4 hours at -10~20°C;
[0016] (2) Take respectively 60Kg and 500Kg of sodium carbonate and water, mix and dissolve, then add it to the product obtained in step (1), stir and crystallize, and centrifuge to obtain 3.4-clindamycin condensate (protectant) wet Taste;
[0017] (3) Dried product obtained by drying: 35.5Kg, weight yield 88.75%.
Embodiment 2
[0019] 3.4-Synthesis of Clindamycin Condensate (Protect)
[0020] (1) Take 80Kg, 250Kg, and 50Kg of clindamycin hydrochloride alcoholate, acetone, and phosphorus oxychloride respectively, mix the above three substances, and heat and stir for 6 hours at -10~20°C;
[0021] (2) Take 100Kg and 1000Kg of sodium carbonate and water respectively, mix and dissolve, then add it to the product obtained in step (1), stir and crystallize, and centrifuge to obtain 3.4-clindamycin condensate (protected product) wet Taste.
[0022] (3) Dried product obtained by drying: 72.5Kg, weight yield 90.63%.
Embodiment 3
[0024] Synthesis of Clindamycin Phosphate
[0025] (1) Get respectively 40Kg, 240Kg, 50Kg, 30Kg, 5Kg, 5Kg of the 3.4-clindamycin condensate (protection) obtained in Example 1 and acetone, phosphorus oxychloride, salt of wormwood, DMAP, TEBA-C1 , mix the above-mentioned substances, and keep warm for 8 hours at -10-20°C;
[0026] (2) Add 2000Kg of water to the product obtained in step (1), and keep it warm for 4 hours at -10 to 20°C;
[0027] (3) Adsorption and crystallization: the product obtained in step (2) is subjected to adsorption, crystallization, and centrifugation to obtain a wet product of clindamycin phosphate according to conventional methods.
[0028] (4) Dried product obtained by drying: 39.1Kg, weight yield 97.75%.
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