Piezoelectric active bone repair composite material and preparation method thereof

A composite material and bone repair technology, applied in medical science, prosthesis, etc., can solve problems such as poor piezoelectric properties and lack of biocompatibility, and achieve improved interface, simple preparation and processing methods, and good tissue compatibility. sexual effect

Active Publication Date: 2014-12-17
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the technical problems that existing materials do not have biocompatibility and poor piezoelectric properties, the present invention provides a piezoelectric active bone repair composite material with biocompatibility and good piezoelectric properties and a preparation method thereof

Method used

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  • Piezoelectric active bone repair composite material and preparation method thereof
  • Piezoelectric active bone repair composite material and preparation method thereof
  • Piezoelectric active bone repair composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Prepare a dopamine aqueous solution with a concentration of 0.01mol / L, and weigh 0.2g of BaTiO with a diameter of 30nm 3 Nano-ceramic particles were ultrasonically dispersed in 20 mL of dopamine aqueous solution, stirred in a water bath at 40°C for 12 h, centrifuged and washed 5 times to obtain barium titanate nano-ceramic particle fillers with a core-shell structure with a dopamine coating thickness of 1 nm (record for BNPDopa);

[0034] (2) Weigh 0.45g BNPDopa and place it in 5mL organic solvent DMF, and use ultrasonic vibration combined with stirring for 2h to make BNPDopa form a stable suspension in the solvent;

[0035] (3) Weigh 2g of polymer P(VDF-TrFE), add 15mL of organic solvent DMF, stir for 4h to completely dissolve;

[0036] (4) adding the suspension obtained in step (2) to the polymer solution in step (3), stirring for 10 h so that BNPDopa is evenly dispersed in the polymer matrix to obtain a mixed solution;

[0037] (5) Take the mixed liquid obtaine...

Embodiment 2

[0040] (1) Prepare a dopamine aqueous solution with a concentration of 0.05mol / L, and weigh 0.6g of BaTiO with a diameter of 100nm 3Nano-ceramic particles were ultrasonically dispersed in 20 mL of dopamine aqueous solution, stirred in a water bath at 60°C for 10 h, centrifuged, and washed three times to obtain barium titanate nano-ceramic particle fillers with a core-shell structure and a dopamine coating thickness of 4 nm (record for BNPDopa);

[0041] (2) Weigh 0.075g BNPDopa and place it in 5mL organic solvent DMF, and use ultrasonic vibration combined with stirring for 1h to make BNPDopa form a stable suspension in the solvent;

[0042] (3) Weigh 2g polymer PVDF, add 15mL organic solvent DMF, stir for 3h to make it completely dissolved;

[0043] (4) Add the suspension obtained in step (2) to the polymer solution in step (3), and stir for 6 hours so that BNPDopa is evenly dispersed in the polymer matrix to obtain a mixed solution;

[0044] (5) Take the mixed liquid obtain...

Embodiment 3

[0047] (1) Prepare a dopamine aqueous solution with a concentration of 0.08mol / L, and weigh 1.2g of BaTiO with a diameter of 200nm 3 Nano-ceramic particles were ultrasonically dispersed in 20 mL of dopamine aqueous solution, stirred in a water bath at 80°C for 6 h, centrifuged and washed 4 times to obtain a barium titanate nano-ceramic particle filler with a core-shell structure with a dopamine coating thickness of 6 nm (record for BNPDopa);

[0048] (2) Weigh 0.9g BNPDopa and place it in 5mL organic solvent DMF, and use ultrasonic oscillation combined with stirring for 2h to make BNPDopa form a stable suspension in the solvent;

[0049] (3) Weigh 2g of polymer P(VDF-TrFE), add 15mL of organic solvent DMF, stir for 6h to completely dissolve;

[0050] (4) adding the suspension obtained in step (2) to the polymer solution in step (3), stirring for 10 h so that BNPDopa is evenly dispersed in the polymer matrix to obtain a mixed solution;

[0051] (5) Take the mixed solution obt...

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Abstract

The invention relates to a piezoelectric active bone repair composite material and a preparation method thereof, aiming at solving the problems that the existing material does not have biocompatibility and is poor in piezoelectric property. The piezoelectric active bone repair composite material comprises ceramic particle filler with a core-shell structure, and polymer matrix, wherein the ceramic particle filler with the core-shell structure is evenly dispersed in the polymer matrix; the core body of the ceramic particle filler with the core-shell structure is formed by ceramic particles, and the surfaces of the ceramic particles are covered by organic matter coating layers. The invention also provides the preparation method of the piezoelectric active bone repair composite material. The preparation method can be widely applied to the field of preparation of the bone repair composite material.

Description

technical field [0001] The invention relates to a surgical repair material, in particular to a piezoelectric active bone repair composite material and a preparation method thereof. Background technique [0002] Implant repair is currently the main method for the treatment of large-scale bone defects. Artificial bone repair materials occupy an important position in bone repair materials due to their wide range of sources, controllable performance and low cost. However, the artificial bone repair materials currently used are still mainly space-occupying replacement repairs, which cannot respond to physiological loads, electromagnetic effects or biochemical stimuli like living tissues, that is, they do not have biological reactivity, and the long-term clinical effect is poor. , The repair rate is high, so that the concept of permanent replacement repair of human hard tissue defects has been greatly challenged. Therefore, the development of bioreactive materials with biomimeti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/48A61L27/46A61L27/50
Inventor 邓旭亮张学慧林元华卫彦沈洋
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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