Preparation method for gel

A gel and inclusion compound technology, applied in the field of drug preparation, can solve problems such as inability to guarantee, and achieve the effects of convenient medication, long-lasting effect and fast dissolution

Inactive Publication Date: 2014-01-22
SUIHUA UNIV
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Problems solved by technology

[0004] In order to solve the problem that the current preparation method of the gel containing Cnidium Fructus cannot guarantee the active ingredient osthole in the Cnidium Fructus extract, which mainly treats bacterial infection and vaginal trichomoniasis, namely 7-methoxy-8-isoamyl Alkenyl coumarins avoid or slow down the problem of oxidative deterioration
Simultaneously, the present invention is also in order to solve the problem of how to improve the water solubility of osthole, how to reduce the irritation and photosensitivity of osthole, so as to guarantee the safety, stability and lasting effect of osthole in the gel containing Cnidium osthole.

Method used

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  • Preparation method for gel

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Embodiment 1

[0044] Crush 120g of dried Cnidium into coarse powder, soak in 60% ethanol solution for 12 hours, extract by percolation, extract by percolation with 12 times the amount of 60% ethanol solution, percolation speed 0.3mL / min, collect percolation liquid Concentrate and dry the percolating liquid to obtain a dry paste; dissolve the dry paste in absolute ethanol to form a nearly saturated alcohol solution, and slowly add it to a 60°C saturated solution prepared by dissolving 20 grams of β-cyclodextrin in about 250 mL of water. In the aqueous solution, stir at a constant temperature of 60° C. for 2 hours; cool, stand still for 6 hours, filter, wash with water and absolute ethanol, and dry to obtain the clathrate of the Cnidium mongolica extract.

[0045] Grind 2 grams of clindamycin hydrochloride finely, and slowly add 20 grams of β-cyclodextrin dissolved in about 250 mL of water into a 60°C saturated aqueous solution; place the solution at a constant temperature of 60°C and stir for...

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Abstract

The invention discloses a preparation method for a gel, belonging to the field of preparation of medicines. The method comprises the following steps: extracting common cnidium fruit to obtain an extract containing osthole and carrying out clathration on the extract by using beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin so as to obtain a clathrate of the extract of common cnidium fruit; treating clindamycin hydrochloride and adding a saturated aqueous solution prepared from beta-cyclodextrin so as to obtain a clindamycin hydrochloride clathrate; and mixing the clathrate of the extract of common cnidium fruit with the clindamycin hydrochloride clathrate, adding hydroxypropyl methylcellulose, water, glycerin, chitosan, a 10% ethylparaben ethanol solution, a 10% aqueous sodium hydrosulphite solution and Tween-80 and carrying out mixing with stirring so as to obtain the gel. With the preparation method provided by the invention, the gel can safely and effectively perform curative effects and has reduced irritation, improved solubility, an accelerated dissolution speed and enhanced bioavailability.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a preparation method of a gel. Background technique [0002] Gel refers to a homogeneous, suspension or emulsion-type latex thick liquid or semi-solid preparation made of a drug and suitable auxiliary materials. Both traditional Chinese medicine and chemical medicine can be made into gel. The bases used to prepare gels can be divided into two categories, namely aqueous gel bases and oily gel bases. Aqueous gel base Carbomer, methyl cellulose, ethyl cellulose, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, gelatin, starch, tragacanth, etc. The oily gel base is mainly made of liquid paraffin and polyoxyethylene or fatty oil and colloidal silicon or aluminum soap, zinc soap. In addition to the gel base, the preparation of the gel also requires additives such as βH regulators, humectants, solubilizers, cosolvents, preservatives, and transdermal absorption accel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/234A61K47/48A61K9/06A61K31/7056A61P31/04A61P33/02A61P15/02
Inventor 赵大伟乔秀丽马松艳
Owner SUIHUA UNIV
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