38results about How to "Convenient clinical administration" patented technology

The present invention relates to a fuliconazole injection. Said injection includes the following components; (by wt%) fuliconazole 0.01-20%, cyclodextrin or cyclodextrin derivative 0%-60%, water-soluble excipient 0-75%, solubilizer 0%-20% and the rest is injection water. Its preparation method includes the following steps: mixing the above-mentioned raw materials, using active carbon to remove impurity and heat source, filtering, fine filtering, filling, sterilizing, checking and putting in storage.

The invention discloses a nimodipine micelle injection and a preparation method thereof. The nimodipine micelle injection is prepared by using active ingredients, i.e. nimodipine and phospholipid/bile salt. According to the nimodipine micelle injection disclosed by the invention, the solubility of the nimodipine is greatly increased, and no crystal precipitation exists when the nimodipine micelle injection is diluted; the biocompatibility of the phospholipid/bile salt is good, and organic solvents with great toxic side effects, such as ethyl alcohol, propylene glycol and the like, are not needed to for solubilizing so that the toxicity of the nimodipine micelle injection is lowered, the vascular stimulation is little, and the adverse reaction of the nimodipine micelle injection is reduced; and the nimodipine micelle injection can be directly used for intravenous injection and can also be used for instilling after the nimodipine micelle injection is diluted to various degrees, and thus, the clinical administration is greatly facilitated.

The invention discloses enrofloxacin sustained-release tablets for pets and a preparation process for the same. The enrofloxacin sustained-release tablets disclosed by the invention are stable in medicine release and safe in medication, as well as is composed of enrofloxacin, a sustained-release or controlled-release material, a filler, an adhesive, a lubricant and a flavouring agent. The enrofloxacin sustained-release tablets prepared by the preparation process disclosed by the invention have the characteristics of being convenient to administrate, lasting in action and stable in curative effect.

The invention belongs to the field of Chinese medicinal preparations for livestock, and specifically relates to a Chinese medicinal compound preparation for protecting liver and removing mildew and a preparation method of the Chinese medicinal compound preparation. The Chinese medicinal compound preparation comprises 10-20 parts of pseudo-ginseng, 10-20 parts of schisandra, 10-15 parts of silybum marianum, 10-20 parts of licorice, 10-15 parts of red-rooted salvia root, 20-30 parts of yeast cell wall, 5-10 parts of vitamin C and 2-5 parts of glucuronolactone. The Chinese medicinal compound preparation can be used for cleaning toxin inside the livestock while removing mildew, and can also improve the immunity of the body so as to strengthen the disease resistance; and all components are safe and non-residual, so the effect is significant.

The invention belongs to the field of feed additives, and mainly relates to a feed additive for improving intestinal environment, and a preparation method thereof. 100 Parts of the feed additive comprise, by weight, 30-50 parts of xylooligosaccharide, 10-20 parts of garlicin, 5-10 parts of lactic acid powder, 5-10 parts of enzyme production probiotics, 10-15 parts of vitamin C, and the balance of anhydrous sugar. All components mutually cooperate with each other and complement each other to promote propagation of beneficial microbes, such as bifidobacteria and lactic acid bacillus and restrict breeding of Escherichia coli and other harmful bacteria in order to make intestinal dysbacteriosis recover balance or be converted to a body benefiting balance state.

The invention discloses ciprofloxacin thermo-sensitive type in-situ gel composition and belongs to the field of veterinary drug preparations. The thermo-sensitive type in-situ gel composition comprises, by weight volume (g/ml), 5%-10% of ciprofloxacin, 20%-26% of poloxamer 407, 0.5%-10% of poloxamer 188, 0.01%-0.04% of edetic acid, 0.009%-0.03% of bacteriostatic agent, and 0.1%-0.2% of antioxidant. Solvent of the composition is acetic acid - sodium acetate buffer solution. The invention further discloses a preparing method of the composition. The ciprofloxacin thermo-sensitive type in-situ gel composition is liquid at room temperature, jelling temperature is close to body temperature, and therefore dosing is convenient and jelling speed is high, jelling strength and adhering function are good, the dosing can be achieved with accurate positioning, and loss of drug is reduced. Furthermore, the ciprofloxacin thermo-sensitive type in-situ gel composition and the preparing method thereof have controlled-releasing and long-acting functions, dosage is low, the number of times of dosing is small, harm caused by implants normally used is avoided, and pain of patients is relieved.

The invention discloses a lipoic acid mixed micelle which is prepared from lipoic acid, phospholipid and sodium lipoate, the components are simple, the drug loading capacity is high, and the obtained mixed micelle has relatively strong stability and can still keep the properties of the micelle after different dilution ratios and long-term storage. The invention further discloses a preparation method of the mixed micelle, and the preparation method is simple in process, high in repeatability and suitable for industrial production. The mixed micelle does not need to be solubilized by ethanol, propylene glycol and other organic solvents with large stimulation, and the obtained mixed micelle has no side effect in use, is safe and reliable, and has the advantages of wide raw material source and low cost. The invention further discloses application of the mixed micelle, the mixed micelle can be used for preparing cosmetics and preparing pharmaceutical compositions from the mixed micelle and pharmaceutically acceptable pharmaceutic adjuvants, the lipoic acid mixed micelle can be prepared into injections, oral preparations and skin coatings and can be used after being diluted to different degrees, and clinical administration is greatly facilitated.

The invention relates to a medicinal composition for treating complex infection and a preparation method thereof. The medicinal composition is characterized by comprising an active ingredient selected from one of glycopeptides antibacterial drugs of telavancin, dalbavancin, oritavancin, vancomycin, teicoplanin or a pharmaceutically acceptable salt thereof, and also comprising polyene and echinocandin type antifungal agents, and being prepared into a freeze-dried powder injection by adopting a conventional process. The medicinal composition provided by the invention realizes combined application of the antibacterial drugs and the antifungal agents, can simultaneously give play to an antibacterial infection effect and an antifungal infection effect, and is convenient for clinical use.

The invention discloses pimobendan sustained-release tablets for a pet and a preparation method thereof. The pimobendan sustained-release tablets disclosed by the invention are stable and safe to use and consist of a solid dispersion of pimobendan, a sustained-release material, a filling agent, an adhesive, a lubricant and a flavoring agent. The pimobendan sustained-release tablets disclosed by the invention have the characteristics of convenience in administration, lasting action and stable curative effect.

The invention relates to the technical field of veterinary medicines, in particular to a preparation technology for compound solution of florfenicol and doxycycline. The preparation technology has the advantages that since the solution is prepared from doxycycline hydrochloride, stress reaction of livestock and poultry is reduced during dosing, contact area of medicine and the absorption part is enlarged, release of the medicine in an acid environment of the stomach is reduced by means of complexation of magnesium ions and the doxycycline hydrochloride, stimulus of the doxycycline hydrochloride to gastric mucosa is avoided effectively, the medicine is transferred to the absorption part of the small intestine directly, and clinical medicinal value of the doxycycline is increased; the florfenicol is added into a doxycycline hydrochloride solution, and the problem of solubility of the florfenicol is solved by the aid of different proportions of corresponding solvents and employing of solubilizing agents.

The invention discloses a medicinal composition containing lentinan. The medicinal composition comprises, by weight, 0.5-5% of lentinan, 1-10% of yeast glucan, 2-10% of levamisole hydrochloride, 5-30% of licorice root extract, and the balance of anhydrous glucose. The invention also discloses a preparation method of the medicinal composition, and a use of the composition in enhancement of the immunity of animals. The medicinal composition which is processed through an ultrafine crushing technology has a high medicine absorption rate, substantially promotes the growth of animal immune organs and enhances the immunity of animal bodies; the medicinal composition has a substantial curative effect on viral disease induced immunosuppression and poor immunity, and substantially reduces the mortality of pathogenetic animals; the medicinal composition substantially increases the antibody tilter of vaccine immunized serum of the animals in order to substantially enhance the vaccine immunization effect; and the composition has the advantages of simple production steps, convenience in clinic use, and convenience in colony administration.

The invention discloses a veterinary drug composition containing traditional Chinese medicine components and a preparation method of the veterinary drug composition, and relates to the technical field of veterinary drug compositions.The veterinary drug composition is mainly prepared from the following raw materials: glucose oxidase, glutathione, pyrantel, decoquinate, astragalus membranaceus, honeysuckle, fructus forsythiae, pseudo-ginseng, salvia miltiorrhiza, angelica sinensis, houttuynia cordata, polyporus umbellatus, ligusticum wallichii, codonopsis pilosula, enzyme-producing probiotics and mannitol. According to the veterinary drug composition containing the traditional Chinese medicine components, various specific types of components are adopted and matched according to specific dosage, the novel veterinary drug composition containing the traditional Chinese medicine components is finally formed, all the components are matched and coordinated, the body balance can be adjusted, and the veterinary drug composition is suitable for enhancing the disease resistance and immunity of livestock. The veterinary drug composition can significantly improve the organism immunity of livestock and poultry and enhance the disease resistance; and the veterinary drug composition has a good inhibition effect on viral diseases, and reduces the death rate of livestock and poultry remarkably.

The invention relates to a traditional Chinese medicine perfusate for treating female endometritis and a preparation method thereof. The traditional Chinese medicine composition of the invention is composed of purslane, rehmannia glutinosa, Guiwei, achyranthes bidentata, Pollen Pollen, Cortex Moutan and Corydalis Corydalis, and auxiliary materials include pH regulator, osmotic pressure regulator and preservative. The composition of the drug in the raw material of the present invention is formed through systematic compatibility research, and has obvious and outstanding synergistic effects. The preparation method thereof can significantly improve the activity of the drug, reduce toxic and side effects, have high bioavailability of the drug, and facilitate clinical administration, etc. .

The invention discloses a compound preparation for cleaning toxins in pig bodies and a preparation method of the compound preparation, wherein the compound preparation comprises the components in parts by weight: 1-2 parts of selenium yeast, 1-2 parts of chromium picolinate, 10-20 parts of glutamine, 10-20 parts of arginine, 10-20 parts of guanidinoacetic acid, 10-20 parts of aflatoxin B1 clastic enzyme for feeds, 10-20 parts of saccharomyces cerevisiae culture, 10-20 parts of acanthopanax and 10-20 parts of astragalus membranaceus. According to the formula, the immunity and production performance of pigs can be improved by cleaning toxins in the pigs, the toxins in the pigs are cleaned according to the physiological characteristics of the pigs, and the compound preparation is prepared by selecting green raw materials, is safe and effective, and is free of residues and drug resistance.

The invention belongs to the technical field of traditional Chinese veterinary medicine processing and biotransformation, and particularly relates to a traditional Chinese medicine fermentation preparation for promoting sow oestrus and a preparation method thereof. The traditional Chinese medicine fermentation preparation for promoting sow oestrus comprises the following raw materials in parts by weight: 3-13 parts of eucommia ulmoides, 3-13 parts of glossy privet fruit, 8-18 parts of angelica sinensis, 3-13 parts of codonopsis pilosula, 8-18 parts of motherwort, 3-13 parts of ligusticum wallichii, 3-13 parts of astragalus membranaceus, 3-13 parts of soybeans, 3-13 parts of semen cuscutae, 3-13 parts of bile acid, 1-7 parts of vitamin E, 1-7 parts of candida utilis, 1-7 parts of lactic acid bacteria and 5-20 parts of glucose. The traditional Chinese medicine preparation disclosed by the invention is high in bioavailability, has a remarkable improvement effect on sow oestrus, and can be used for effectively treating non-oestrus of sows.