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Preparation technology for compound solution of florfenicol and doxycycline

The technology of doxycycline and florfenicol is applied in the field of preparation technology of florfenicol and doxycycline compound solution to achieve the effects of reducing the stress of livestock and poultry, avoiding irritation and avoiding drug resistance

Inactive Publication Date: 2015-11-04
济南亿民动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At the same time, the present invention adds florfenicol to the doxycycline solution, utilizes different proportioning of corresponding solvents and the use of solubilizing agent, solves the problem of florfenicol solubility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 10g of doxycycline, 1.3g of citric acid, add 35g of dimethylacetamide, heat at 45°C, and stir for 40min.

[0026] Slowly add 10 g of florfenicol while stirring, stir until dissolved, add 35 g of glycerin as the organic phase.

[0027] Add 0.2 g of sodium metabisulfite, 0.1 g of EDTA, 2 g of polyethylene glycol 400, and 4 g of polysorbate 80 into 15 g of purified water in sequence, and stir until dissolved to form an inorganic phase.

[0028] The above-mentioned inorganic phase was slowly added into the organic phase, and stirred for 20 minutes to prepare the florfenicol-doxycycline compound solution formulation of this example.

[0029] The preparation is used to treat a case of broiler chickens infected with colibacillosis, and the effective rate reaches 85%.

Embodiment 2

[0031] Take 5g of doxycycline, 10g of citric acid, add 25g of dimethylformamide, heat at 50°C, and stir for 45min.

[0032] Slowly add 10 g of florfenicol while stirring, stir until dissolved, add 50 g of propylene glycol as the organic phase.

[0033] Take 0.2 g of sodium sulfite, 0.1 g of citric acid, 2 g of polyethylene glycol 400, and 2 g of polysorbate 80 and add them into 10 g of purified water in sequence, stir until dissolved, and use it as an inorganic phase.

[0034] The above-mentioned inorganic phase was slowly added into the organic phase, and stirred for 20 minutes to prepare the florfenicol-doxycycline compound solution formulation of this example.

[0035] A case of broiler chickens infected with colibacillosis was treated with this preparation, and the cure rate reached 90%.

Embodiment 3

[0037] Take 10g of doxycycline, 5g of citric acid, add 30g of α-pyrrolidone, heat at 55°C, and stir for 50min.

[0038] Slowly add 5 g of Florfenicol while stirring, stir until dissolved, add 40 g of glycerin as the organic phase.

[0039] Add 0.1 g of sodium bisulfite, 0.1 g of EDTA, 2 g of gelatin, and 40 g of polysorbate into 15 g of purified water in sequence, and stir until dissolved to form an inorganic phase.

[0040] The above-mentioned inorganic phase was slowly added into the organic phase, and stirred for 30 minutes to prepare the florfenicol-doxycycline compound solution formulation of this example.

[0041] A case of broiler chickens infected with colibacillosis was treated with this preparation, and the cure rate reached 88%.

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PUM

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Abstract

The invention relates to the technical field of veterinary medicines, in particular to a preparation technology for compound solution of florfenicol and doxycycline. The preparation technology has the advantages that since the solution is prepared from doxycycline hydrochloride, stress reaction of livestock and poultry is reduced during dosing, contact area of medicine and the absorption part is enlarged, release of the medicine in an acid environment of the stomach is reduced by means of complexation of magnesium ions and the doxycycline hydrochloride, stimulus of the doxycycline hydrochloride to gastric mucosa is avoided effectively, the medicine is transferred to the absorption part of the small intestine directly, and clinical medicinal value of the doxycycline is increased; the florfenicol is added into a doxycycline hydrochloride solution, and the problem of solubility of the florfenicol is solved by the aid of different proportions of corresponding solvents and employing of solubilizing agents.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a preparation process of a compound solution of florfenicol and doxycycline. Background technique [0002] Bacterial diseases of livestock and poultry are common and frequently-occurring diseases in the breeding process of large-scale farms and farmers, and have become the main factor that endangers the development of livestock and poultry industry. For the treatment of bacterial diseases, the combined use of florfenicol and doxycycline can expand the antimicrobial spectrum and enhance the curative effect, which has become a classic formula for clinical use. [0003] However, the doxycycline hydrochloride tablets included in the 2010 edition of the "People's Republic of China Veterinary Pharmacopoeia" are currently used in livestock and poultry, which is inconvenient to administer, increases the stress of animals, and easily causes digestive tract damage and gastric u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K9/08A61P31/04A61K31/165
Inventor 周玉武王涛马金焕杨建朋
Owner 济南亿民动物药业有限公司
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