22 results about "Veterinary pharmaceuticals" patented technology

Veterinary pharmaceutical compositions for direct systemic introduction, also known as DSI pharmaceutical compositions. One veterinary pharmaceutical composition for direct systemic introduction includes about 10-17 dry mass % bovine gelatin; about 10-17 dry mass % mannitol; about 0-1 dry mass % of a surfactant; and about 65-80 dry mass % of the active pharmaceutical ingredient which is a proton pump inhibitor. A method of manufacturing a veterinary pharmaceutical composition for direct systemic introduction includes combining one or more pharmacologically inactive compounds to form a first solution; using one or more surfactants to form a second solution; adding an active pharmaceutical ingredient to the second solution to form a first mixture; adding the first solution to the first mixture to form a pre-formulation; freezing the pre-formulation; and lyophilizing the pre-formulation.

The utility model discloses a self -cleaning formula air circulation ventilation device of veterinary drug clean workshop, specifically related to veterinary drug clean workshop ventilation technical field. Self -cleaning formula air circulation ventilation device of veterinary drug clean workshop described in the utility model, including rectangular frame rectangular frame, louver, ventilation mechanism, electrostatic precipitation mechanism, ash removal mechanism and dust collecting component, the front and rear two ends of rectangular frame outer wall are fixedly connected with fixed frame board respectively, the outer wall of louver is fixedly connected in the front side of rectangular frame inner wall respectively, the outside of ash removal mechanism is set in the top of rectangular frame and is close to the back side of ventilation mechanism. The utility model discloses a work through the control ventilation mechanism, utilizes high -speed airflow to inhale the dust such as impurity in the workshop through louver into rectangular frame, then utilizes high -voltage electric field to make gas ionization again, thereby makes dust particle electrification and is adsorbed by electrode dust removal, promotes workshop air circulation ventilation.

The invention discloses a method for preparing a sheep-derived positive serum reference of yersinia enterocolitica, obtained positive serum and application of the positive serum, and belongs to the field of veterinary medicine products. The invention aims to solve the technical problem of how to obtain the yersinia enterocolitica sheep-derived positive serum reference which is stable in titer and character and can be used for specific detection of brucella diagnostic products. Therefore, the invention provides a method for preparing the yersinia enterocolitica sheep-derived positive serum reference, which comprises the following steps: immunizing a tested sheep by using an immunizing antigen, and collecting serum of the immunized tested sheep to obtain the yersinia enterocolitica sheep-derived positive serum reference. The immune antigen is an inactivated yersinia enterocolitica obtained by inactivating the yersinia enterocolitica. The positive serum reference can be effectively applied to quality control evaluation work of brucellosis related diagnosis products, and plays a positive role in prevention and control of brucellosis.

The present invention relates to an oral liquid veterinary pharmaceutical composition comprising an isoxazoline compound selected from the group consisting of fluralaner, afoxolaner, lotilaner, and sarolaner, designed to effectively treat and control ectoparasite infestations in livestock, specifically cattle. The composition is formulated as a ready-to-use aqueous suspension that includes a viscosity agent, surfactant, and suspending agent.

The utility model relates to processing veterinary medicine technical field, and disclose a kind of concentration device for processing veterinary medicine, including sealed bucket, processing jar and base, the sealed bucket is fixedly connected with processing jar, this concentration device for processing veterinary medicine, by placing installation piece to the bottom of processing jar, coarse filter plate is slid in the inner wall of processing jar, control torsion piece drives card piece and the insertion of processing jar's mouth to be engaged connection, tank cover and sealed bucket and processing jar are sealed connection, No. 1 stirring rod is inserted with installation piece, control servo motor operates, drive main tooth disc meshing linkage two secondary tooth discs to rotate, drive two No. 2 stirring rod, installation piece, scraper and No. 1 stirring rod to rotate synchronously in processing jar, scraper and installation piece are rotatably connected with the inner wall of processing jar, to fully stir, reduce the sediment of not easy to dissolve, reduce the effect of causing influence drug quality.

The invention provides a veterinary ciprofloxacin lactate injection, which belongs to the field of veterinary pharmaceutical preparations. The veterinary ciprofloxacin lactate injection uses water for injection as a solvent and comprises components with the following concentrations: 2.5-12.7 g / 100 mL of ciprofloxacin lactate, 10-30 mL / 100 mL of propylene glycol, 10-30 mL / 100 mL of glycerol, 0.5-2 mL / 100 mL of lactic acid, 2-20 g / 100 mL of a beta-cyclodextrin derivative, 5-20 mL / 100 mL of glycerol formal, 0.5-2 mL / 100 mL of benzyl alcohol, 0.5-1.5 g / 100 mL of sodium chloride, and 0.005-0.5 g / 100 mL of an antioxidant; and the degree of substitution of the beta-cyclodextrin derivative is 2-12. The veterinary ciprofloxacin lactate injection of the present invention has high concentration and strong stability, can remain stable at room temperature or even low temperature, and meets the relevant quality requirements of the veterinary drug quality standards (2017 edition).

The utility model relates to the technical field of veterinary drug pharmacy, and discloses a veterinary drug uniform blending device with a wall sticking prevention structure, which comprises a stirring barrel, a scraping component is arranged in the stirring barrel, and a cleaning component is arranged at the bottom of the stirring barrel; the scraping assembly comprises a stirring shaft, the stirring shaft is rotationally embedded in the stirring barrel, a motor bin is fixedly installed at the top of the outer surface of the stirring barrel, an output shaft of a motor in the motor bin is fixedly connected with the stirring shaft, and a reciprocating lead screw is rotationally embedded in the stirring barrel; a scraping plate is arranged on the outer surface, close to the bottom, of the reciprocating screw rod, and a plurality of limiting sliding rods are embedded in the scraping plate in a sliding mode, so that the problems that veterinary drugs are easily attached to the inner wall of the device when the veterinary drugs are stirred, and an existing device lacks a treatment device for the attached veterinary drugs are solved; and the production quality of the veterinary drugs is influenced by non-uniform mixing of the veterinary drugs in the use process.

The utility model relates to the technical field of veterinary medicine production and processing, in particular to veterinary traditional Chinese medicine and additive secondary dry-wet mixing equipment which comprises a supporting frame, a platform is installed at the upper end of the supporting frame, and a convenient-to-use assembly is arranged on the upper side of the platform; the convenient-to-use assembly comprises a sliding groove formed in one side of the platform, and a movable frame is clamped and embedded in the inner wall of the sliding groove. According to the secondary dry-wet mixing equipment for the veterinary traditional Chinese medicine and the additive, quantitative operation can be conveniently carried out on input liquid medicine by adjusting the position of a shifting valve, the dosage is observed through scale marks, and the operation is convenient. According to the secondary dry-wet mixing device for the veterinary traditional Chinese medicine and the additive, the electromagnetic valve is used for controlling opening and closing, the high-pressure nozzle is used for spraying to the outer wall of the solid medicine, and the fluted disc drives the gear ring to rotate, so that the mixing tank is conveniently driven to turn over, secondary dry-wet mixing of the medicine in the mixing tank is uniform, and the use efficiency of the secondary dry-wet mixing device for the veterinary traditional Chinese medicine and the additive is improved.

The invention provides a sustained-release bar for repairing mammary glands in the early stage of dry milk of dairy cows and a preparation method thereof, and belongs to the technical field of veterinary pharmaceutical preparations. The breast repair slow-release bar for the dairy cow in the early stage of dry milk is prepared from the following raw materials in parts by weight: 6 to 10 parts of compound plant extract, 10 to 15 parts of ferroferric oxide, 8 to 12 parts of magnesium oxide, 6 to 10 parts of zinc sulfate, 1 to 5 parts of hordenine hydrochloride, 1 to 5 parts of manganese sulfate, 0.05 to 0.15 part of calcium iodate, 0.05 to 0.15 part of sodium selenite, 0.5 to 2 parts of calcium stearate and 3 to 10 parts of vegetable oil. The breast repair slow-release bar for the dairy cow in the initial dry period can effectively promote emptying and involution of breasts of the dairy cow in the dry period, the involution period is remarkably shortened, the risk of mastitis infection in the dry period is reduced, and the repair effect of the breast repair slow-release bar is better than that of natural milk stop.

The invention belongs to the technical field of veterinary pharmaceutical preparations, and particularly relates to a cefadroxil flavored chewable tablet for pets and a preparation method thereof, the cefadroxil flavored chewable tablet comprises the following components: 20-50% of cefadroxil, 30-60% of a filler, 3-8% of a disintegrating agent, 5-15% of a phagostimulant, 0.5-2% of a lubricant and 0.1-1% of a flavoring agent, the phagostimulant is selected from at least one of animal hydrolyzed protein, yeast extract and fish meal, a double-layer taste modifying technology is adopted, namely, taste masking and phagostimulant are combined, and through dog and cat experiment verification, the palatability is larger than 90%. According to the technology, the bad taste of the medicine can be effectively covered, meanwhile, the phagostimulant is utilized to attract pets, and the enthusiasm of the pets to take medicine is greatly improved.

The utility model relates to preparation partial shipment technical field, especially a kind of veterinary medicine preparation partial shipment device, including support frame, support frame inside is equipped with conveying mechanism, conveying mechanism is equipped with multiple packaging guide plate, and each packaging guide plate upper end is fixed with packaging fixed pin, it further includes medicine guiding mechanism and partial shipment mechanism. The rotation of adjusting screw rod is used to drive adjusting frame to move on partial shipment frame and let vertical board slide in partial shipment groove synchronously, so as to quickly expand or reduce the capacity of partial shipment groove filled with veterinary medicine preparation, and the veterinary medicine preparation in partial shipment groove is guided out to the partial shipment packaging box in the movement of partial shipment frame, two impact rods are alternately pushed by the movement of connecting shaft driving gear rack to move, and then the impact ball on impact rod reciprocates in the movable cavity and hits, and then the whole veterinary medicine preparation falls down by the vibration when packing funnel is filled with medicine, so as to avoid solid veterinary medicine preparation blockage and affect partial shipment precision.

The invention relates to the technical field of veterinary pharmaceutical preparations, and discloses a preparation method of a diclazuril-containing compound anticoccidial preparation, which comprises the following steps: mixing and heating diclazuril, amprolium hydrochloride and a hydrogen bond donor to form a uniform liquid eutectic system; adding anhydrous organic acid into the system, and uniformly dispersing to obtain a drug loading system; and finally, adsorbing the drug carrying system on an inert carrier, and drying and granulating to obtain the preparation. According to the invention, insoluble diclazuril is subjected to amorphous dispersion at a molecular level by using a eutectic technology, and anhydrous organic acid is introduced as a structural disintegration component for water response. When the preparation encounters water, the components are preferentially hydrated to destroy the hydrogen bond network of the eutectic system, resulting in disintegration of the system. The preparation prepared by the method solves the technical problems of slow dissolution of diclazuril and asynchronous release of the diclazuril and the amprolium hydrochloride, realizes synchronous and rapid release of the two active components, and the obtained amorphous system has high physical stability and good flowability of the final product.

The utility model discloses veterinary drug preparation filling equipment, which comprises a conveyor belt, a weighing mechanism, a feeding mechanism and a discharging mechanism, and the filling mechanism is arranged above the conveying belt in a lifting mode and comprises a plurality of filling heads communicated with the liquid supply mechanism, fan-shaped nozzles are arranged at the bottom ends of the filling heads, annular nitrogen curtains are arranged on the outer sides of the fan-shaped nozzles, the output ends of the annular nitrogen curtains are vertically arranged downwards, and vacuum recovery valves are communicated with the interiors of the filling heads. Air in a preparation bottle can be exhausted in advance in the filling process through the annular nitrogen curtain, the preparation bottle is filled with nitrogen, splashing of liquid medicine can be effectively reduced through the fan-shaped nozzle, the probability that the liquid medicine makes contact with the air is reduced, the liquid medicine in the filling head can be recycled into the liquid supply mechanism through the vacuum recycling valve, the liquid medicine of the next batch is prevented from being polluted, and the filling efficiency is improved. The liquid medicine is in a nitrogen environment in the whole process from a liquid supply mechanism to filling, and the titer loss rate of easily oxidized components is reduced from 10%-15% to lt; 1%.

The invention belongs to the technical field of veterinary pharmaceutical preparations, and discloses an oxiratinib nanosuspension in-situ gel and a preparation method thereof. Each 100 mL of the gel comprises the following components: 80 mL of a drug active component, 12-25 g of poloxamer 407, 0.1-1 g of carboxymethyl chitosan, and the balance of water for injection. The active pharmaceutical ingredient exists in the form of a nano suspension; and the nano suspension contains the oxiratinib. The preparation is a liquid which is easy to push and inject before being injected, and is quickly converted into a gel storage under the action of body temperature after being injected subcutaneously, so that medicine slow release as long as once a month can be realized, the administration frequency is greatly reduced, the application compliance of pets is improved, and the long-term management cost is reduced. A composite gel matrix composed of poloxamer 407 and carboxymethyl chitosan is screened out through a large number of experiments, and forms a stable system with the olatinib nanocrystals, so that the stability of the preparation during storage and the expected gelation and release behaviors after injection are ensured.

The veterinary drug mixing production line comprises an auxiliary material manufacturing module, a preliminary mixing module and a high-speed shearing mixing module, the auxiliary material manufacturing module comprises an auxiliary material tank and an auxiliary material stirring driving part, an auxiliary material inlet and an auxiliary material outlet are formed in the auxiliary material tank, and the auxiliary material stirring driving part is arranged on the auxiliary material tank and used for stirring auxiliary materials; the primary mixing module comprises a main material tank body, a main material stirring driving part and an auxiliary material extracting part, a main material inlet and a main material discharging pipe are arranged on the main material tank body, and the auxiliary material extracting part is used for connecting the auxiliary material outlet with the main material tank body and extracting auxiliary materials into the main material tank body; the main material stirring driving part is arranged on the main material tank body and is used for primarily stirring a mixed medicament of the auxiliary material and the main material; the high-speed shearing module comprises a shearing tank body and a shearing assembly, a shearing feeding opening is formed in the shearing tank body, the main material discharging pipe is connected with the shearing feeding opening, and the shearing assembly is used for conducting high-speed shearing on the mixed medicament so that solvent particles of the mixed medicament can reach the required size.

A tylosin derivative and a preparation method and application thereof are provided. The tylosin derivative has a structure represented by in Formula 1. A veterinary pharmaceutical composition and a pharmaceutical preparation containing the tylosin derivative, and use of them in treating or preventing bacterial infection diseases in animals are also provided. Moreover, a feed additive including the tylosin derivative is provided.

A macrolide compound and a preparation method and application thereof are provided. The macrolide compound has a structure represented by Formula I. A pharmaceutical composition or a veterinary pharmaceutical composition, which includes the macrolide compound with a structure represented by Formula I, is also provided. Moreover, a pharmaceutical preparation, which includes the macrolide compound with a structure represented by Formula I, is provided. The macrolide compound, veterinary pharmaceutical composition and pharmaceutical preparation can be used to treat pathogen infections, especially to treat pathogen infections in animals, with a significant effect.

The invention belongs to the technical field of veterinary pharmaceutical preparations, and discloses a JAK inhibitor nano suspension injection and a preparation method thereof. Each 100 mL of the injection comprises the following components: 80 mL of a pharmaceutical active component, 15-25 g of poloxamer 407, 0.2-1 g of carboxymethyl chitosan, and the balance of water for injection, the active pharmaceutical ingredient exists in the form of a nano suspension; the nano suspension contains the ilunitinib, and the nano suspension contains the ilunitinib. The invention provides a drug delivery system which is high in drug loading capacity and has quick effect and long-acting maintenance effects, so that the slow release of drugs is realized, the lasting time of the drug effect is prolonged, and the defects of difficulty in swallowing, poor compliance and frequent drug delivery of affected dogs caused by existing dosage forms are overcome. The invention aims at solving the problems that the solubility of the ilunitinib in water, an oil phase and an oil-soluble matrix is low and the difficulty in developing a liquid preparation is high, and the ilunitinib injection is prepared and has important clinical value.

An injectable veterinary pharmaceutical composition comprising the combination of an isoxazoline compound and a macrocyclic lactone as a solution in a carrier comprising a pharmaceutically acceptable gel forming agent, a pharmaceutically acceptable solvent, and a release modifying agent.

The invention discloses basic bismuth salicylate chewable tablets for dogs and a preparation method of the basic bismuth salicylate chewable tablets, and belongs to the technical field of veterinary pharmaceutical preparations. The basic bismuth salicylate chewable tablet for dogs is prepared from the following raw and auxiliary materials in percentage by mass: 45-60% of basic bismuth salicylate, 15-25% of a filler, 5-15% of an adhesive, 5-15% of a disintegrating agent, 0.5-3% of a lubricant and 8-20% of a flavoring agent, the preparation method comprises the following steps: uniformly mixing the basic bismuth salicylate and the filling agent; adding a disintegrating agent accounting for 40-60% of the total amount, uniformly mixing, and then adding an adhesive to enable the material to present a proper humidity that the material is clustered when held and is dispersed when touched; after granulating, drying until the water content is 1-3%; and adding the rest disintegrating agent, lubricant and flavoring agent, uniformly mixing, and tabletting to obtain the basic bismuth salicylate chewable tablet for dogs. The basic bismuth salicylate chewable tablet for dogs has the characteristic of rapid disintegration and excellent palatability.

The invention discloses a veterinary soluble scourge-clearing and toxin-vanquishing powder-amoxicillin compound preparation and application thereof. The preparation is prepared by mixing 700g of soluble scourge-clearing and toxin-vanquishing powder containing 14 traditional Chinese medicines and 300g of soluble amoxicillin powder according to the ratio of 7: 3. The invention relates to the technical field of veterinary pharmaceutical preparations, in particular to a veterinary soluble scourge-clearing and toxin-vanquishing powder-amoxicillin compound preparation and application thereof, and due to the adoption of the technical scheme, the veterinary soluble scourge-clearing and toxin-vanquishing powder-amoxicillin compound preparation has the following advantages that the soluble preparation is quick to dissolve, free of precipitation, uniform in drinking water administration and high in absorption efficiency, covers virus and bacterium dual infection, and is free of toxic and side effects. Omnibearing treatment is achieved on the disease chain of virus pathopoiesis-bacterial secondary, the insoluble defect is overcome, and the method is suitable for large-scale breeding and has a good prospect.