Eupatorium clenbuterol preparation capable of preventing and treating respiratory diseases of livestock and poultry and production technique thereof

A production technology and respiratory technology, which is applied in the field of preparation of new preparations of Chinese patent medicines, can solve problems such as patient restrictions, achieve the effects of complete extraction, enhanced body antibacterial, and broad market prospects

Inactive Publication Date: 2011-09-07
方希修 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The deficiencies of this existence: 1. there is a large part of sucrose in Perrin syrup,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0027]Take 500g of Peilan, Scutellaria baicalensis, Forsythia, Platycodon grandiflorum, and licorice medicinal materials, chop them up, add water and reflux to extract twice, add 8 times the amount of water for the first time, add 6 times the amount of water for the second time, extract for 1 hour each time, and then The obtained extracts were combined and filtered, and the extracts were concentrated under reduced pressure to 500 mL. At this time, the crude drug content in the concentrate was 1.0 g / mL, and then ethanol was added to make the alcohol content in the concentrate reach 60%, and it was allowed to stand for 24 hours. Filtrate, concentrate the filtrate under reduced pressure, dry to a thick paste, add sucrose powder, dry, pulverize, and pack to obtain Perrin powder.

specific Embodiment approach 2

[0028] Specific embodiment two: take 1000g of Peilan, scutellaria baicalensis, forsythia, platycodon grandiflorum, and licorice decoction pieces, add water and decoct 3 times, decoct for 5h, 3h, and 2h respectively each time, combine the obtained extracts, filter, and concentrate at normal pressure to 2000mL, at this time, the crude drug content in the concentrated solution is 2.0g / mL, then add chitin solution, let it stand for 12h to filter, then concentrate the filtrate under reduced pressure, dry under reduced pressure to obtain a dry extract, add starch, carboxymethyl cellulose Vegetarian sodium auxiliary material, the granules are prepared by dry granulation, and the Peilan granules are obtained after packaging.

specific Embodiment approach 3

[0029] Specific embodiment three: get Peilan, scutellaria baicalensis, forsythia, Platycodon grandiflorum, Radix Glycyrrhiza L00kg, add water decoction 5 times, decoct respectively 2h, 2h, 1h, 1h, 1h each time, the gained extract is combined, filtered, and then Concentrate to 1000L under normal pressure. At this time, the crude drug content in the concentrated solution is 1.5g / mL. The concentrated solution passes through a macroporous resin column, elutes with 50-95% ethanol, collects the eluate, and then concentrates the eluate under reduced pressure. To a thick paste, spray-dry to powder, add dextrin and low-substituted hydroxypropyl cellulose auxiliary materials, and dry granulate to obtain a granule equivalent to 12g of raw medicinal material per gram of granule, and finally pack to obtain Perrin granules.

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Abstract

The invention relates to the field of a veterinary pharmaceutical and a feed additive, particularly relates to a production method of eupatorium (lindley eupatorium) clenbuterol powder and a granular formulation for preventing and treating respiratory diseases, namely a preparation method of eupatorium clenbuterol powder and the granular formulation. In the method, five Chinese medicinal crops, such as eupatorium and the like or decoction pieces and the like are taken as raw materials. The preparation method comprises the following steps: cutting the Chinese medicinal crops, such as eupatorium and the like into pieces; adding water; carrying out backflow extract; carrying out concentration, membrane separation or ordinary pressure concentration to obtain a concentrated solution; carrying out alcohol precipitation on the concentration solution or adding flocculant for clarification, membrane separation or resin absorption to remove ineffective components; concentrating, drying, smashing, adding a flavoring agent, an excipient or auxiliary materials composed by the flavoring agent and the excipient; and packaging. In the invention, the advantages of traditional Chinese medicine combination and a carrier or filler are combined; the process is optimized through experiments; the effective components of the traditional Chinese medicine are extracted completely, and the process is simple and feasible, and has easily controlled process. The formed product has no harmful residues, and is a safe and hormone-free green product. The preparation method provided by the invention is especially suitable for preventing and treating the respiratory diseases of livestock and poultry, and simultaneously also suitable for preventing and treating the respiratory diseases of animals, such as various pets and the like.

Description

(1) Technical field [0001] The invention relates to a preparation method of a new preparation of a Chinese patent medicine, specifically a method for preparing a Peilan powder and a granule by using five traditional Chinese medicinal materials such as Peilan, baicalin, forsythia, platycodon, licorice, or their decoction pieces as raw materials. The invention is particularly suitable for the prevention and treatment of poultry respiratory diseases, and is also suitable for the prevention and treatment of animal respiratory diseases such as various livestock and pets. (2) Background technology [0002] Poultry upper respiratory tract infection refers to the disease caused by the invasion of pathogenic microorganisms in the upper respiratory tract of poultry. Common respiratory diseases in poultry (take chickens as an example) are mainly caused by viruses, bacteria and Mycoplasma septicemia, etc. The main clinical features are tearing, runny nose, cough, wheezing, rales, dyspne...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K9/14A61K9/16A61P11/00
CPCY02A40/70
Inventor 方希修王寿轩王冬梅朱本康朱涛
Owner 方希修
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