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Compound coccidiostat pharmaceutical formulation

An anti-coccidial and anti-avian coccidiosis technology is applied in the directions of anti-infective drugs, drug combination, drug delivery, etc., and can solve the problems of inability to mix in drug premix, no drug premix ability, and high local drug concentration, To achieve the effect of improving bioavailability and use effect, improving convenience and extending the validity period

Inactive Publication Date: 2008-02-27
青岛康地恩实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2. For most small and medium-sized farms, there is no drug premixing ability, and the drug premix cannot be evenly mixed into the full-price feed, resulting in local drug concentrations that are too high or too low, resulting in adverse consequences

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Preparation method and steps: Weigh amprolium hydrochloride and dissolve it in 350ml purified water, stir to dissolve; weigh ethopabate and dissolve it in 100ml N-methylpyrrolidone; weigh sulfaquinoxaline sodium and dissolve it in 350ml N-methylpyrrolidone Pyrrolidone; after mixing the above three liquids, adjust the pH value to 10.0 with an appropriate amount of ethanolamine; dissolve 2 g of sodium thiosulfate in a small amount of purified water, add the above mixed liquid, stir and mix, and then add purified water to 1000 ml. A brownish-red transparent liquid was obtained. Then filter, sub-package, that is.

[0020] When in use, 1000ml of this solution preparation is mixed with 4000L of water for clinical poultry coccidiosis. It is prohibited during the laying period, and the withdrawal period is 7 days.

Embodiment 2

[0023] Preparation method and steps: Weigh amprolium hydrochloride and dissolve it in 300ml purified water, stir to dissolve; weigh ethopabate and dissolve it in 100ml N-methylpyrrolidone; weigh sulfaquinoxaline sodium and dissolve it in 300ml N-methylpyrrolidone Pyrrolidone; after mixing the above three liquids, adjust the pH value to 10.0 with an appropriate amount of ethanolamine; dissolve 2 g of sodium thiosulfate in a small amount of purified water, add the above mixed liquid, stir and mix, and then add purified water to 1000 ml. A brownish-red transparent liquid was obtained. Then filter, sub-package, that is.

[0024] When in use, 1000ml of this solution preparation is mixed with 2000L of water for clinical poultry coccidiosis. It is prohibited during the laying period, and the withdrawal period is 7 days.

Embodiment 3

[0027] Preparation method and steps: Weigh amprolium hydrochloride and dissolve it in 300ml purified water, stir to dissolve; weigh ethopabate and dissolve it in 100ml N-methylpyrrolidone; weigh sulfaquinoxaline sodium and dissolve it in 300ml N-methylpyrrolidone Pyrrolidone; after mixing the above three liquids, adjust the pH value to 10.0 with an appropriate amount of ethanolamine; dissolve 2 g of sodium thiosulfate in a small amount of purified water, add the above mixed liquid, stir and mix, and then add purified water to 1000 ml. A brownish-yellow transparent liquid was obtained. Then filter, sub-package, that is.

[0028] When in use, 1000ml of this solution preparation is mixed with 1000L of water for clinical poultry coccidiosis. It is prohibited during the laying period, and the withdrawal period is 7 days.

[0029] According to clinical tests, the anti-coccidial effective rate of this agent is 94%, and the cure rate is 78%. Compared with the premix with the s...

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PUM

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Abstract

The invention discloses an animal medicine agent of compound coccidiostat, which comprises the following parts: 5-20%(W / V) promazine hydrochloride, 0. 25-1% (W / V) ethoxy amide benzenemethyl ester and 3-12%(W / V) sulfanilamide quinoxaline sodium, wherein the solvent, solutizer and necessary anti-oxidizing agent and pH value adjuster are added into the raw materials to produce the product with good anti-caecum coccidian effect. The invention is easy to dissolve in the water to solve the drug giving problem that the ill poultry is provided with water without fodder, which is convenient to spread with good spreading and using value.

Description

technical field [0001] The invention relates to an anticoccidial veterinary drug, in particular to a compound anticoccidial drug preparation for poultry. Background technique [0002] Coccidiosis in poultry is mainly caused by intestinal parasites of the genus Eimeria, which has the characteristics of wide incidence, great harm and strong drug resistance. Although many places have adopted coccidiosis vaccines for epidemic prevention, they have not been widely used, and chicken coccidiosis is still mainly controlled by drugs. According to reports, there are more than 40 kinds of coccidial drugs, and more than 20 are commonly used, but most of them will develop drug resistance after several years or even one or two years of use. Rational use of drugs can effectively prolong the occurrence of drug resistance. Rational drug use includes common methods such as combination drug use, drug rotation, and shuttle drug use. Combination medication is the most convenient, effective an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K9/08A61K47/22A61P33/02A61K31/216A61K31/506
Inventor 徐福亮周玉武
Owner 青岛康地恩实业有限公司
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