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Veterinary use radix isatidis and dyers woad leaf granule and preparation method thereof

A technology of granule and Radix isatidis, which is applied in the field of veterinary isatid granule and its preparation, can solve the problems of low cure rate, slow effect, and weak drug effect, and achieve the effect of strong drug effect, quick effect, and simple and effective materials

Inactive Publication Date: 2018-06-22
山东信合生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Banqing granules sold in the market have weak efficacy, slow effect, and low cure rate. For large poultry farms, they often cause great losses

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1) Weigh 600 g of Radix Isatidis, 900 g of Folium Isatidis and 600 g of Bupleurum bupleuri, add water to decoct for 2 times, 1 hour each time, combine the decoction, filter, and take the filtrate to obtain solution I;

[0026] 2) Add 20g of aloe polysaccharide to solution I prepared in step 1), and concentrate it to obtain solution II; carry out precipitation treatment on solution II, and separate the precipitate and supernatant in solution II; The liquid is concentrated to a thick paste to obtain an extract;

[0027] 3) Add sucrose and dextrin to the extract prepared in step 2), mix evenly, granulate and dry with 50% ethanol to obtain veterinary banqing granules; during the process, the material decreases due to decoction and concentration in the early stage , add sucrose and dextrin according to the final yield of 2100 g of Banqing Granules for Veterinary Use.

experiment example 1

[0029] Test animals: 35-day-old broiler chickens.

[0030] Symptoms: 3 days after the onset, some of the large group were listless, opened their mouths and stretched their necks, made a "grunt" sound, coughed, shook their heads, had a lot of mucus in the mouth and throat, decreased food intake, and loose yellow-green or white stools.

[0031] Autopsy results: autopsy showed cecal tonsil bleeding, larynx and trachea congestion or hemorrhage, and a lot of mucus, glandular stomach bleeding points were rare, small intestine had catarrhal inflammation and bleeding, rectal streaked bleeding, ileum, Cecal tonsil hemorrhage, diagnosed as atypical Newcastle disease.

[0032] Test method: select 50 diseased broilers and randomly divide them into a control group and an experimental group, with 25 birds in each group. The control group is treated with commercially available Banqing Granules, and the experimental group is treated with the Banqing Granules prepared in Example 1. Days, obse...

experiment example 2

[0037] Experimental animals: 2,000 50-day-old Sanhuang broiler chickens.

[0038] Symptoms: 4 days after the onset, the large group was not in good spirits, and more than 40 animals died every day.

[0039] Autopsy results: pericarditis, perihepatitis, peritonitis, gastric mucosal bleeding, intestinal mucosal bleeding, spleen necrosis, pancreatic necrosis, hemorrhage, severe tracheal hemorrhage, mixed infection of mild influenza and colibacillosis .

[0040] Therapeutic drugs: commercially available conventional antibacterial drugs, Banqing granules prepared in Example 1.

[0041] Treatment results: the use of commercially available conventional antibacterial drugs has no significant effect; using the Banqing granules prepared in Example 1 combined with commercially available conventional antibacterial drugs for 2 days, the number of deaths per day was reduced to 5, and the spirit improved. On the third day of medication, 1 animal died , feeding returned to normal.

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PUM

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Abstract

The invention discloses a veterinary use radix isatidis and dyers woad leaf granule and a preparation method thereof, and belongs to the field of veterinary medicines. The veterinary use radix isatidis and dyers woad leaf granule is characterized by being prepared from the following raw materials including 500 to 800g of radix isatidis, 800 to 1000g of dyers woad leaves, 500 to 800g of radix bupleuri and 10 to 30g of aloe polysaccharide. The preparation method comprises the following steps of weighing the radix isatidis, the dyers woad leaves and the radix bupleuri; adding water for decorationand boiling for 2 to 4 times, wherein each time lasts 0.5 to 2h; merging decoration liquid; performing filtering; taking filter liquid to obtain a first solution; adding the aloe polysaccharide intothe first solution; performing concentration to obtain a second solution; performing precipitation treatment on the second solution; separating precipitates and supernate; concentrating the supernateto the thick paste state to obtain an extract; adding cane sugar and dextrin into the extract; after the uniform mixing, performing granulation and drying to obtain the veterinary use radix isatidis and dyers woad leaf granule. The veterinary use radix isatidis and dyers woad leaf granule has the advantages that the medication is simple and effective; the effects of clearing away heat and toxic materials and cooling the blood are achieved; the veterinary use radix isatidis and dyers woad leaf granule can be used for treating warm and heat diseases such as wind-heat type common cold, swollen sore throat and fever with eruption. Compared with the existing radix isatidis and dyers woad leaf granule, the veterinary use radix isatidis and dyers woad leaf granule provided by the invention has the advantages that the medicine effect is high; the effect taking speed is high.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a veterinary ischid granule and a preparation method thereof. Background technique [0002] Traditional Chinese medicine granules are a dosage form developed on the basis of decoctions and syrups. It not only ensures all the characteristics of decoctions, but also has fast absorption, strong efficacy, and high efficacy. At the same time, it does not need to be boiled and can be taken directly , and has the advantages of less dosage, safe and hygienic, convenient to carry and store, and is very suitable for clinical administration in modern and intensive farms. [0003] Banqing Granule is a Chinese patent medicine, which has the functions of reducing swelling and dissipating stagnation, strengthening the heart, diuresis and gallbladder, antibacterial and anti-inflammatory, antiviral, and enhancing immunity. It is a common veterinary prescription. Banqing granule has a good ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/315A61K36/855A61K36/704A61K36/233A61K9/16A61P31/04A61P29/00A61P31/12A61P37/04A61K31/715
CPCA61K9/1652A61K31/715A61K36/195A61K36/233A61K36/315A61K36/704A61K36/855A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 牛汝勇
Owner 山东信合生物制药有限公司
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