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Oral liquid vaccine for preventing and controlling avian influenza of domestic animals and domestic birds and method of preparing the same

An avian influenza and oral liquid technology, which can be applied to medical preparations containing active ingredients, pharmaceutical formulations, and liquid transportation, etc. The effect of suppressing avian influenza virus

Inactive Publication Date: 2008-10-08
辽宁天鹏生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003]At present, there is a shortage of prevention and treatment drugs for bird flu, and the prevention mainly depends on vaccines and interferon, which are expensive and have certain side effects

Method used

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  • Oral liquid vaccine for preventing and controlling avian influenza of domestic animals and domestic birds and method of preparing the same
  • Oral liquid vaccine for preventing and controlling avian influenza of domestic animals and domestic birds and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment one: preparation of oral liquid 1 of the present invention

[0017] (1) Weigh 10 grams of Forsythia, 10 grams of Asarum, 5 grams of Maodongqing, 15 grams of Anemarrhena, 8 grams of wild chrysanthemum, 10 grams of polygala, 10 grams of lobelia, 2 grams of snake gall, 10 grams of ox gall, and 40 grams of aloe vera. gram, rock sugar 25 grams.

[0018] (2) Add water to decoct the raw materials except rimantadine and azithromycin twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1 hour, combine the two decoctions Liquid, filtered to obtain the filtrate, concentrated into an extract with a specific gravity of 1.35, adding 85-95% edible glacial acetic acid for extraction, recovering the glacial acetic acid and concentrating, drying at 45-50°C to obtain 15.05 grams of dry extract;

[0019] (3) Grinding the dry extract into powder, adding 5 grams of rimantadine and 3 grams of...

Embodiment 2

[0021] Embodiment two: preparation of oral liquid 2 of the present invention

[0022] (1) Weigh 20 grams of forsythia, 25 grams of asarum, 20 grams of holly, 30 grams of Anemarrhena, 20 grams of wild chrysanthemum, 20 grams of polygala, 25 grams of lobelia, 5 grams of snake gall, 25 grams of ox gall, and 60 grams of aloe. gram, rock sugar 40 grams.

[0023] (2) Add water to decoct the raw materials except rimantadine and azithromycin twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1 hour, combine the two decoctions liquid, filtered to obtain the filtrate, concentrated into an extract with a specific gravity of 1.35, adding 85-95% edible glacial acetic acid for extraction, recovering the glacial acetic acid and concentrating, drying at 45-50°C to obtain 28.1 grams of dry extract;

[0024] (3) Grinding the dry extract into powder, adding 15 grams of rimantadine and 10 grams of azithro...

Embodiment 3

[0026] Embodiment three: preparation of oral liquid 3 of the present invention

[0027] (1) Weigh 13 grams of Forsythia, 18 grams of Asarum, 16 grams of Maodongqing, 22 grams of Anemarrhena, 15 grams of wild chrysanthemum, 15 grams of polygala, 23 grams of lobelia, 3 grams of snake gall, 18 grams of ox gall, and 32 grams of aloe. gram, rock sugar 32 grams.

[0028] (2) Add water to decoct the raw materials except rimantadine and azithromycin twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1 hour, combine the two decoctions Liquid, filtered to obtain the filtrate, concentrated into an extract with a specific gravity of 1.35, adding 85-95% edible glacial acetic acid for extraction, recovering the glacial acetic acid and concentrating, drying at 45-50°C to obtain 28.63 grams of dry extract;

[0029] (3) Grinding the dry extract into powder, adding 10 grams of rimantadine and 8 grams of...

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Abstract

The invention relates to a veterinary pharmaceutical composition and a preparation method thereof. The veterinary pharmaceutical composition of the invention is a vaccine oral solution for the prevention and the treatment of bird flu of domestic animal and fowl, and is prepared by the raw materials according to the following parts by weight: 10 to 20 parts of forsythia suspensa, 10 to 25 parts of asarum, 5 to 20 parts of ilex pubescens, 15 to 30 parts of rhizoma anemarrhenae, 8 to 20 parts of wild chrysanthemum, 10 to 20 parts of polygalae, 10 to 25 parts of lobelia chinensis, 2 to 5 parts of snake galls, 10 to 25 parts of ox to gall, 40 to 60 parts of aloe, 25 to 40 parts of rock sugar, 5 to 15 parts of rimantadine and 3 to 10 parts of azithromycin. The oral solution of the invention can be directly used as daily feed for feeding domestic animals and fowl, which can effectively inhibit bird flu virus, reduce the infection rate of respiratory tract and lung and prevent domestic animal and fowl from being infected by bird flu.

Description

【Technical field】 [0001] The invention relates to a veterinary pharmaceutical composition and a preparation method thereof. 【Background technique】 [0002] Avian influenza is the abbreviation of avian influenza. It is an infectious disease caused by a subtype of influenza A virus (also known as avian influenza virus). True fowl plague or European fowl plague. According to the different types of pathogens, avian influenza can be divided into three categories: highly pathogenic, low pathogenic and non-pathogenic avian influenza. Non-pathogenic avian influenza does not cause obvious symptoms and only produces virus antibodies in infected birds. Low-pathogenic avian influenza can cause mild respiratory symptoms, reduced food intake, decreased egg production, and sporadic deaths in poultry. Highly pathogenic avian influenza is the most serious, with high morbidity and mortality, and infected flocks are often "wiped out". [0003] At present, there is a shortage of prevention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K9/08A61K9/10A61P31/16A61K31/13A61K31/7016A61K31/7048A61K35/413A61K35/58A61K35/583
Inventor 谢兴荣刘治西唐兆新郭世宁汪连涛王芝武帮勇吴国辉陈胜叶亚多潘永发林仕
Owner 辽宁天鹏生物科技股份有限公司
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