26 results about "Ox gall" patented technology

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of anti-hepatoma medicines. The traditional Chinese medicine composition comprises red ginseng, ox horn tip, musk, borneol, safflower, bezoar, radix aconiti lateralis praeparata slice, venenum bufonis, pseudo-ginseng, benzoin and pearl. Experimental results show that the traditional Chinese medicine composition can induce apoptosis and necrosis of liver cancer cells and inhibit proliferation of the liver cancer cells; and liver cancer cells are retarded to be in a G1 cell cycle. Therefore, the invention provides a new therapeutic drug for clinical treatment of liver cancer, and the raw materials are natural medicinal materials, have wide sources and have good application prospects.

The invention provides a high-fidelity calculus bovis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. According to the technical scheme provided by the invention, the high-fidelity calculus bovis is accurately prepared by taking the mean value of the contents of various components of the natural calculus bovis as a reference and accurately measuring the contents of various components in the raw materials, fully utilizing the original components of the ox bile or ox gall powder, not adding other non-calculus bovis components and combining the existence forms of the components. The problems that existing artificial calculus bovis is greatly different from natural calculus bovis in efficacy, and toxic and side effects are relatively high are solved. The shape, the forming process and the components of the product are highly similar to those of natural calculus bovis; the medicine effect of the calculus bovis is improved, and the production cost is reduced.

The utility model relates to the field of calculus bovis selecting devices, in particular to a calculus bovis selecting device capable of reducing loss. Comprising a box body, two rubber gloves are installed in the box body, a connecting pipe is installed at one end of the box body, an air extracting pump is installed at the end, away from the box body, of the connecting pipe, a supporting frame is installed at the end, close to the air extracting pump, of the box body, the air extracting pump is installed on the supporting frame, and a collecting structure is arranged at the end, close to the supporting frame, of the box body. The collecting structure comprises two connecting rods, the two connecting rods are fixedly connected with the box body, and the ends, away from the box body, of the connecting rods are fixedly connected with a shell. The calculus bovis picking device capable of reducing the loss has the advantages that manual picking operation or manual picking operation is carried out in the negative pressure device through the negative pressure device, calculus bovis powder in the picking process can be collected through the air outlet which exhausts air outwards, and the calculus bovis loss is reduced.

The invention relates to an Angong bezoar pill and a preparation method thereof. The Angong bezoar pill contains 0.2 part of a bionic rhinoceros horn biological agent, 0.1 part of the bionic rhinoceros horn biological agent, 0.025 part of musk, 0.05 part of pearl, 0.1 part of cinnabar, 0.1 part of realgar, 0.1 part of coptis chinensis, 0.1 part of scutellaria baicalensis, 0.1 part of cape jasmine, 0.1 part of radix curcumae and 0.025 part of borneol for compatible use. The similarity between the core chemical components of the bionic rhinoceros horn biological agent and the natural rhinoceros horn reaches 95% or above, and the composition and content of active substances meet the drug effect requirements.

The application belongs to the field of biological pharmacy, and particularly discloses a preparation method of musk heart-activating dropping pills, which comprises the following steps: preparing a salvia miltiorrhiza clear paste, mixing the salvia miltiorrhiza clear paste, artificial musk, total ginsenosides of ginseng stems and leaves, toad venom, artificial ox gall, bear bile powder and borneol with polyethylene glycol 6000 and polysorbate 80, stirring and uniformly mixing, dropping, centrifuging, screening, drying and coating to prepare the musk heart-activating dropping pills. The application has remarkable clinical curative effect, no side effect, high drug stability, fast dissolution, high efficiency and rapid effect. The application further discloses a preparation device of the musk heart-activating dropping pills, wherein the vertical silica gel cleaning strips, the first silica gel cleaning strips and the second silica gel cleaning strips in the silica gel cleaning net frame and the silica gel cleaning strip component are cross arranged, can be in friction contact with different surfaces of the salvia miltiorrhiza in the cleaning process, and can provide comprehensive and detailed cleaning effect. The design not only increases the cleaning area, but also can effectively remove the small dust and impurities on the surface of the salvia miltiorrhiza, and avoids the dead angle which is easily missed in the traditional cleaning mode.

The application discloses a kind of vacuum belt drying equipment and method of ox gall powder fitting type feed, including raw material tank, vacuum drying machine, screw conveyor, pulverizer and dry powder tank, the vacuum drying machine is equipped with conveying belt, the bottom of the conveying belt is equipped with heating mechanism for material drying, the vacuum drying machine is further equipped with fixedly connected separation plate, the separation plate is attached to the surface of corresponding conveying belt for material separation, the separation plate is equipped with the cutting knife that can move up and down above, and separation plate is equipped with the cutting groove corresponding with cutting knife, the cutting knife is equipped with multiple adjusting grooves, the retractable and rotatable turnover lever is equipped in the adjusting groove, the rotatable turnover plate is equipped in the end of the turnover lever, the discharge end of the separation plate is further equipped with baffle.This way of heating, can more effectively improve the overall drying efficiency, make material heated more evenly, improve the drying efficiency of material.

The application discloses a kind of prevention and cure medicine of fatty liver and preparation method thereof, and medicine includes effective component: Sanqi 0.1-100 parts;Artificial ox gall 0.1-100 parts;Radix Bupleuri 0.1-100 parts;Shaddock 0.1-100 parts;Danshen 0.1-100 parts and Yujin 0.1-100 parts;Preparation method includes initial preparation step: take the following weight parts of effective component: Radix Bupleuri 1-8 parts;Shaddock 1-6 parts;Danshen 1-8 parts;Yujin 1-8 parts;White Peony Root 1-8 parts;Buddha's hand 1-6 parts;Plumeria 1-5 parts;Yuzhu 1-10 parts;Lotus leaf 1-8 parts;Turmeric 1-5 parts;Alisma 1-8 parts;Yinchen 1-10 parts;Tianji Huang 1-10 parts and Licorice 1-4 parts;Water is soaked, decoct, filter and combine filtrate, and is concentrated into thick paste;Mixing step: Sanqi is crushed into coarse powder, and thick paste is mixed uniformly, dried, and after being crushed, it is fully ground, sieved, mixed uniformly with artificial ox gall, and obtained;Medicine is the treatment criterion with soothing liver and relieving depression, regulating qi and reducing phlegm, removing stasis and reducing turbidity, and dosage combination conforms to oral mode and is easily absorbed by human body.

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of a liver cancer resisting medicine. The traditional Chinese medicine composition comprises red ginseng, ox horn, musk, borneol, safflower, ox gall, appendices, toad venom, panax notoginseng, storax and pearl. Experimental results show that the traditional Chinese medicine composition can induce apoptosis and necrosis of liver cancer cells, inhibit proliferation of the liver cancer cells, and block the liver cancer cells in the G1 phase of the cell cycle. Therefore, the application provides a new treatment medicine for clinical treatment of liver cancer, and the raw materials are natural medicinal materials, are widely sourced, and have a good application prospect.

The invention relates to a Western Huang active component double-gel preparation and a preparation method thereof, the Western Huang active component double-gel preparation comprises frankincense and myrrh oil gel and bezoar musk hydrogel, and the mass ratio of the frankincense and myrrh oil gel to the bezoar musk hydrogel is (10-20): (60-70). Compared with the prior art, the Western Huang active component double-gel preparation disclosed by the invention has the following advantages that supercritical extracts of frankincense and myrrh are creatively used as active pharmaceutical ingredients and an oil phase matrix at the same time, so that the use of traditional auxiliary materials is reduced, the potential toxic and side effects are reduced, and the drug loading capacity of the preparation is also remarkably improved. According to the design, the release rate of the effective components in the prescription can be effectively regulated and controlled, and the drug release regularity is enhanced, so that more stable blood concentration is realized, the curative effect of the drug is fully exerted, and the overall treatment effect is further improved. In addition, the preparation process is simple and convenient and has a good industrial application prospect.

The invention discloses Sanmiao ointment and a preparation method thereof, and relates to the technical field of medicines.The Sanmiao ointment is prepared from a first medicinal material component and a second medicinal material component in proportion, and the first medicinal material component comprises bezoar, musk and dog food; and the medicinal material component II comprises liquorice, safflower, sappan wood, frankincense and myrrh. According to the Sanmiao ointment and the preparation method thereof, the medicinal materials are pretreated, the medicinal material component I is ground into fine powder, and the medicinal material component II is cleaned, cut into sections or sliced and then aired, so that effective components of the medicinal materials are separated out more easily in the subsequent decocting process, and a good foundation is laid for the curative effect of the ointment; pure manually-ground sesame oil prepared through multiple processes is used as an oil material, treated mountain spring water is used as pharmaceutical water, an iron cauldron conforming to the specification and treated fuel are matched, and through the decocting step of strictly controlling the temperature and time, it is ensured that effective components of medicinal materials are fully fused and purified, and the medicinal effect is achieved. The quality and the curative effect of the ointment are further improved.

The invention relates to the technical field of traditional Chinese medicines, in particular to application of a traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating chronic obstructive pulmonary disease. The traditional Chinese medicine composition comprises antelope horn powder, pearl powder, bezoar, stiff silkworm, cinnabar, amber, arisaema cum bile, borneol and rhizoma acori graminei oil. The traditional Chinese medicine composition provided by the invention can be used for remarkably enhancing the lung function, improving the airway limitation condition and improving the symptoms such as tachypnea, irregular rhythm, cough and asthma; the total number of leukocytes, the number of lymphocytes, the number of neutrophils and expression of inflammatory factors are reduced, airway inflammation is improved, and therefore the chronic obstructive pulmonary disease is treated in a multi-target mode.

The invention discloses a Wanchu capsule preparation method capable of reducing harmful impurities and improving overall stability, and belongs to the technical field of traditional Chinese medicine preparations, the Wanchu capsule preparation method comprises the following steps: S1, mixing rhizoma picrorhizae, rhizoma coptidis, catechu and fragrant ink according to a formula ratio, crushing into fine powder to form a mixture I, adding powdered sugar into the mixture I, and uniformly stirring and mixing to form a mixture II; mixing and grinding borneol and artificial musk to form a mixture III; s2, boiling the ox bile for 10-30 minutes, and filtering to obtain filtrate; s3, adding an adjusting stabilizer into the filtrate, wherein the adding amount of the adjusting stabilizer is that the pH value of the filtrate is adjusted to 7.2-7.8; s4, adding the formula amount of bear gall powder and calculus bovis into the filtrate adjusted in S3 to form a mixture IV; s5, adding the mixture II into the mixture IV to form a mixture V, then adding an ethanol water solution, and performing granulation, drying, granule finishing and screening through a granulator to obtain intermediate granules; and S6, uniformly mixing the mixture III with the intermediate particles, sub-packaging, and filling into capsules to prepare the Wanchu capsules. Harmful impurities are reduced, and the overall stability is improved.

The invention discloses a method for in-vitro cultivation of natural-quality calculus bovis by adopting biological enzyme, and relates to the technical field of traditional Chinese medicine preparation, and the method comprises the following steps: S1, adding zinc-manganese alloy nanoparticles (the atomic ratio of zinc to manganese is 1: 0.5) and an EGCG-rosmarinic acid-tea polyphenol ternary compound (the mass ratio of the three components is 1: 1.2: 0.8) into fresh ox bile according to the mass ratio of 1000: (0.8-1.2): (3.0-4.5), and uniformly stirring; and magnetically stirring at 55-65 DEG C for 30-35 minutes to form a nanoscale redox microenvironment, thereby obtaining the pretreated bile. According to the invention, the first controllable, standardized and green calculus bovis in-vitro culture system in the world is constructed through three-dimensional technical innovation of nano material synergism, multienzyme engineering coupling and supercritical purification.

The invention relates to a preparation method for producing calculus bovis by a chemical fermentation technology, which is characterized in that animal bile such as cattle (pigs, sheep and poultry) is used as a raw material, and the calculus bovis is produced by a modern process technology. The composition is prepared from the following components in parts by weight: 8 to 15 parts of taurine, 13 to 26 parts of ox gall powder, 1 to 12 parts of cholic acid, 1 to 17 parts of zinc sulfate, 1 to 15 parts of bilirubin, 20 to 40 parts of calcium gluconate, 20 to 38 parts of deoxycholic acid, 1 to 16 parts of cholesterol, 0.1 to 4.5 parts of fatty acid, 0.05 to 0.95 part of amylase and 0.05 to 2.22 parts of honeysuckle flower extract.

The application discloses a burn and scald ointment, which comprises the following components in parts by mass: 10-20 parts of radix harmel, 5-15 parts of gardenia, 1-5 parts of ox gall, 3-8 pieces of centipede, 1-3 parts of musk, 5-15 parts of smilax, 5-15 parts of buckwheat, 5-10 parts of coptis, 25-35 parts of oyster shell, 3-8 parts of amber, 5-15 parts of catechu, 3-8 parts of borneol, 5-15 parts of radix scrophulariae, 5-15 parts of bletilla, and 3-8 parts of beeswax. The burn and scald ointment has the effects of clearing heat and resolving toxin, cooling blood and removing stasis, removing corruption and promoting tissue regeneration, and relieving pain, and is suitable for various burn and scald injuries, such as water scald, gasoline, sulfuric acid, and gunpowder burn, pitch burn, lime, cement, and electric shock injury. After use, the burn and scald ointment has good effect, and I-II degree recovery only leaves slight scar.

The application belongs to the technical field of traditional Chinese medicine processing, and particularly relates to a preparation process of Angong Niuhuang Pill medicine powder, which comprises the following steps: 1) crushing four kinds of medicinal materials of Coptis chinensis, Gardenia, Scutellaria baicalensis and Curcuma zedoary according to a prescription amount, and preliminarily crushing the four kinds of medicinal materials into 40-60 mesh mixed powder A for standby; 2) putting prescription amounts of ox gall, concentrated water buffalo horn powder, artificial musk and borneol into a low-temperature vibration grinder, and grinding under the condition of-20 to-15 DEG C; putting prescription amounts of cinnabar superfine powder, pearl superfine powder and realgar superfine powder into the low-temperature vibration grinder, and continuing to grind under the condition of-20 to-15 DEG C to obtain mixed powder B; and 3) putting the mixed powder B into the mixed powder A, and continuing to grind and crush. The application adopts low-temperature grinding, avoids volatilization loss of borneol, musk, ox gall and other medicines containing heat-sensitive components, simultaneously completes mixing of the medicine powder in powder modification inclusion grinding, saves the traditional sieving and mixing processes, simplifies production operation, and reduces pollution and loss.

The utility model relates to the field of calculus bovis processing and production, in particular to automatic calculus bovis processing and production equipment. Comprising a base, a crushing disc is installed on the upper surface of the base, a feeding hopper is installed on one side of the crushing disc, a discharging pipe is installed on the side, close to the feeding hopper, of the base, a switch is installed on one side of the base, a screening structure is arranged on the side, close to the discharging pipe, of the base, and the screening structure comprises two fixing rods; the two fixing rods are fixedly connected with the base, sliding frames are slidably connected to the arc surfaces of the fixing rods, connecting blocks are fixedly connected to the sides, close to each other, of the two sliding frames, and a storage box is fixedly connected to the ends, close to each other, of the two connecting blocks. The automatic calculus bovis processing and producing equipment has the advantages that crushed calculus bovis can be conveniently screened, the situation that the product quality is reduced due to incomplete calculus bovis crushing is avoided, and the calculus bovis which is not completely crushed can be conveniently subjected to secondary crushing.

The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition containing ox gall, a pharmaceutical preparation and application, the present application provides a traditional Chinese medicine composition containing ox gall, which has the effects of clearing heat and resolving toxins, cooling liver and resolving lung, dispersing wind and relieving pain, and the preparation has a wide range of uses, the preparation method of the composition provided by the present application is easy to operate, and through years of production practice accumulation, the quality of the obtained product is stable and controllable, and the product is used for preparing drugs for treating liver and lung heat accumulation, wind and fire disturbance, dizziness, oral and nasal sores, wind and fire toothache, sudden eye inflammation, skin itching and other diseases in clinic, and has a wide application value.

The utility model relates to the technical field of medicine processing auxiliary equipment, in particular to a bezoar bed which comprises a shell and a cloth bag, a convex thorn group is arranged outside the shell, one end of the shell is provided with a circular opening, the other end of the shell is provided with a connecting port, and the bottom end of the cloth bag extends into the shell and is fixedly connected with the connecting port; when the bezoar bed needs to be implanted into the cow gall bladder, a deposition medium is added into the shell, the cloth bag is folded to wrap the outer side of the shell, the cloth bag is closed below the connecting port, and then the bezoar bed is implanted into the cow gall bladder; friction force between the calculus bovis and the gall bladder can be increased, a calculus bovis bed is prevented from flowing into the intestinal canal or blocking the bile duct through the bile duct, calculus bovis crystal precipitation is facilitated, the crystal attachment surface is improved, the calculus bovis crystal adsorption capacity is better, and the calculus bovis yield is improved.

The application discloses a preparation method of a general-purpose capsule with reduced harmful impurities and improved overall stability, and belongs to the technical field of traditional Chinese medicine preparations. S1, formula amount of picrorhiza scrophulariiflora, coptis, catechu and fragrant ink are mixed and crushed into fine powder to form a mixture one, sugar powder is added into the mixture one and stirred and mixed uniformly to form a mixture two; borneol and artificial musk are mixed and finely ground to form a mixture three; S2, bovine bile is boiled for 10-30 min, filtered, and a filtrate is obtained; S3, a stabilizing agent is added into the filtrate, and the amount of the stabilizing agent is adjusted to pH 7.2-7.8; S4, formula amount of bear bile powder and ox gall are added into the filtrate adjusted in S3 to form a mixture four; S5, the mixture two is added into the mixture four to form a mixture five, and an ethanol aqueous solution is further added, and the mixture is granulated, dried, and screened by a granulator to obtain intermediate granules; S6, the mixture three and the intermediate granules are uniformly mixed, packaged, and filled into capsules to obtain the general-purpose capsule. The general-purpose capsule has reduced harmful impurities and improved overall stability.

The application provides a qualitative detection method of blood components of Moschus Tongxin dripping pills, specifically, 43 blood components of radix et rhizoma Ranae, salvia miltiorrhiza, total ginsenosides of ginseng stem and leaf, artificial ox gall and bear gall powder in Moschus Tongxin dripping pills are synchronously detected by using ultra-high performance liquid chromatography-tandem mass spectrometry. In the liquid phase condition, a carbon eighteen filler chromatographic column is used, the mobile phase A is 0.05%-0.2% formic acid water, the mobile phase B is 0.05%-0.2% formic acid acetonitrile, and gradient elution is adopted; in the mass spectrometry condition, an electrospray ion source is used, positive and negative ion scanning is adopted, the ion source temperature is 550 DEG C-600 DEG C, the atomizing gas pressure is 50 psi, the auxiliary gas pressure is 45-55 psi, the curtain gas pressure is 30-40 psi, the declustering potential is 80-120 V, the collision energy is 10-60 V, and the mass range is m / z 50-1500 Da. The detection method provided by the application can study the compound traditional Chinese medicine as a whole, has many detection indexes, short detection time and simple pretreatment, and is suitable for promotion.

The invention discloses a method for increasing the yield of bezoar through specific forage combination feeding. According to the method, through scientific treatment and directional feeding of the ox gall powder residues, appropriate physiological conditions are created for bezoar formation. Active ingredients in the treated residues are more easily absorbed by cattle, the gallbladder contraction rhythm is mildly adjusted, cholestasis is induced, and cholesterol is crystallized and separated out, which is the core mechanism of calculus bovis generation; meanwhile, due to the interval feeding rhythm, continuous stimulation is guaranteed, excessive burden cannot be caused to the hepatobiliary system of the cattle, the calculus bovis can be gradually formed in a stable physiological environment, the yield of the calculus bovis is increased from the source, and the double advantages of resource recycling and breeding health guarantee are achieved. Originally possibly discarded ox gall powder residues are converted into effective raw materials after being treated, the breeding cost is reduced, meanwhile, waste discharge is reduced, and the method is suitable for practical application of farmers.

The present application relates to the technical field of Mongolian medicine, and discloses a Mongolian medicine composition for treating irregular menstruation and hemostasis, which is based on the theory of treating liver blood together in Mongolian medicine, and solves the technical pain points of existing hemostatic Mongolian medicine by accurately limiting the proportion of core medicinal materials: the amount of mountain bitterleaf is 1.5 to 2.5 times that of safflower, the amount of bear gall powder is basically the same as or slightly higher than that of safflower, and the amount of ox gall powder is equal to or approximately equal to that of bear gall powder. This optimized proportion solves the problems of non-optimized compatibility ratio of classic Mongolian medicine prescriptions, weak synergistic effect of key medicinal materials, and single action dimension of modern purification scheme, which is difficult to harmonize blood heat and complex pathogenesis. The effects of various medicinal materials form a deep synergy, mountain bitterleaf clears liver heat, safflower and bear gall powder clear blood heat in the vein, and ox gall powder strengthens detoxification and anti-inflammatory effect. In animal models, the hemostatic effect is improved by more than 20% on average, the anti-inflammatory effect is outstanding, and a breakthrough is achieved from single-point hemostasis to multi-dimensional systemic regulation.

The invention discloses double-layer temperature-sensitive microcapsule essential oil for improving swelling and a preparation method of the double-layer temperature-sensitive microcapsule essential oil, and belongs to the technical field of medicines. The microcapsule essential oil is prepared from a mixed core material, an inner-layer wall material, an outer-layer wall material and an oil phase system, and the mixed core material is prepared from frankincense, paeonol, dragon's blood, myrrh, agilawood, calculus bovis, tea oil and a lauric acid-myristic acid binary mixture; the raw materials of the inner-layer wall material comprise gelatin and Arabic gum; the outer-layer wall material is prepared from the following raw materials: hydroxypropyl methyl cellulose and modified montmorillonite. According to the preparation method, the loss of volatile active ingredients in the processing process is effectively reduced, and the embedding rate and the storage stability are improved. During use, the temperature of hot compress skin enables the phase change material in the core material to generate phase change, pressure is generated from the inside, and meanwhile, the outer layer wall material is actively broken to synergistically realize release of active components; and the microcapsule essential oil structure can improve the transdermal effect of the active ingredients and further promote the transdermal absorption, so that the swelling effect is improved.

The application discloses a traditional Chinese medicine composition for clearing heat and resolving toxins, benefiting the throat and eliminating swelling, and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: Houttuynia cordata 10-20 parts, Astragalus root 8-15 parts, Andrographis 8-15 parts, Figwort 8-15 parts, Platycodon 8-15 parts, Monotropa 8-15 parts, Honeysuckle 2-6 parts, Bupleurum 2-6 parts, Belamcanda 2-6 parts, Peucedanum 2-6 parts, Marsh Marigold 1-4 parts and artificial ox gall 0.1-0.6 parts. The traditional Chinese medicine composition has the effects of clearing heat and resolving toxins, benefiting the throat and eliminating swelling, relieving cough and reducing sputum, and is used for treating fever caused by wind-heat invading the lung and lung heat being in excess, nasal discharge of sticky or yellow phlegm, sore throat, cough and expectoration, yellow and thick sputum, headache and body pain, red tongue and yellow tongue fur and the like, and is also used for treating influenza, acute upper respiratory tract infection, acute pharyngitis, tonsillitis and the like. The effect is better than that of each proportion.

The invention relates to the technical field of medicine preparation, and discloses a heart-nourishing dropping pill supercritical CO2 extraction and freeze-drying process which comprises the following steps: S1, selecting heart-nourishing dropping pill raw materials, cleaning, removing impurities and crushing; s2, extracting fructus choerospondiatis, fructus gardeniae, flos carthami, radix angelicae sinensis and poria cocos through an alcohol extraction process, extracting semen myristicae, ferula asafetida, agilawood, fructus tsaoko, cumin, radix aucklandiae, calculus bovis factitius and saffron crocus through a CO2 supercritical extraction process, and directly crushing to be used S3, uniformly stirring the extract and a dripping pill matrix to prepare liquid medicine; s4, preparing dropping pills from the liquid medicine by adopting an electrospinning-3D printing composite molding technology, and dropping the dropping pills into cooling liquid for cooling molding; and S5, atomizing the coating material into nano-scale particles through a nano spray dryer, uniformly coating the surfaces of the dropping pills with the nano-scale particles, and bottling after the dropping pills are inspected to be qualified.