32 results about "Continuous stimulation" patented technology

The invention establishes a method for in-vitro amplification of a CD8+T cell and a cell subset of the CD8+T cell. By adding a TLR1 / 2 agonist, a TLR2 / 6 agonist and a TLR5 agonist into an in-vitro culture system for conventionally culturing and amplifying the CD8+T cell or conjunctively utilizing the agonists, the amplification efficiency of the CD8+T cell can be remarkably improved; besides, by utilizing a TLC agonist, the functional CD8+T cell subsets which are difficult to amplify under a conventional culture condition are amplified, such as PD-1+CD8+T cells and TEM CD8+T cells; and the CD8+T cells and the functional cell subsets can be rapidly and largely propagated under the common and continuous stimulation of a TLRs agonist, recombinant cell factors IL-2, IL-7 and IL-15, an anti-human CD3 antibody and anti-human CD28 antibody coated magnetic beads.

A device for sexual stimulation, intended for enhancing arousal, facilitating orgasm and improving blood circulation in the genitals to correct sexual inadequacy, comprises two elongated members mutually connected with their first ends. At least one of the members is made of a resilient material such as silicon rubber so that its second end is bent off the second member and adapted to be resiliently brought toward the second member second end to form a dildo. The second end of the first member can be fixedly attached to the second member when brought toward it. At least one vibrating device can be placed in one of the members. The device provides for vaginal extension without extension of a vaginal opening, increases a zone of stimulation, is suitable for frictions in the vagina and makes it possible to achieve intense and continuous stimulation of internal genitals when performing frictional stimulation.

The invention provides a continuous-stimulation tissue occlusion gun which can be used in cooperation with a nail bin containing a plurality of closing nails. The continuous-stimulation tissue occlusion gun is characterized by comprising an inner rod, a sleeve and a stimulation unit, wherein the inner rod is sleeved with the sleeve, the sleeve and the inner rod can relatively slide, and the stimulation unit is arranged between the inner rod and the sleeve and can slide along with the sleeve. The upper section of the inner rod is segmented into a left forceps foot and a right forceps foot. The two forceps feet can extend out of the sleeve to be opened. The sleeve slides forwards so that the two forceps feet can be closed again. The inner side faces of the front ends of the two forceps feet are provided with nail grooves with opposite openings. The nail grooves can be detachably clamped to the nail bin. The stimulation unit is provided with two stimulation blocks and stimulation handles, wherein the stimulation blocks are located on the inner side face of the front end of the sleeve and arranged oppositely, and the stimulation handles are connected to the bottoms of the stimulation blocks respectively and exposed out of the outer wall of the lower end of the sleeve. The stimulation blocks correspond to the nail grooves and can stimulate a single closing nail in sequence. The stimulation handles are used for controlling the stimulation blocks. The continuous-stimulation tissue occlusion gun can reduce wounds, is easy to operate and can be continuously used.

The invention discloses a lucidity maintaining device. The lucidity maintaining device is a head-mounted device and consists of a sensing controller and a head-mounted carrier which is sleeved at the head, wherein the sensing controller and the head-mounted carrier are mechanically fixed and electrically connected into a whole; the sensing controller comprises a micro-electromechanical system (MEMS) gyroscope, a control module and a power supply module; the head-mounted carrier comprises a vibration module and a wearable carrier for bearing the vibration module; the MEMS gyroscope performs real-time data acquisition and data processing on triaxial angular velocity signals; the control module is used for calculating and identifying the class of the head action of a person and executing instruction operation corresponding to the head action; the vibration module is used for providing consciousness vibration stimulation to the person. The lucidity maintaining device can realize consciousness vibration stimulation conveniently and timely, can select vibration modes and adjust vibration strength and frequency, achieves an obvious and continuous stimulation effect, is favorable for maintaining excellent lucidity of the person, and has wide application occasions.

The invention discloses a method for improving the spawning efficiency of holothuria leucospilota through continuous stimulation. By means of the operation of the steps of parent holothurian treatment, drying in the shade and parturition hastening, male and female parent holothurian separation, continuous stimulation and the like, the spawning efficiency of tropical female holothuria leucospilotais improved, sufficient holothuria leucospilota fertilized ova are obtained, and large-scale cultivation of tropical holothuria leucospilota fry is possible. The method is easy to operate, low in requirement on equipment and suitable for popularization, and provides technical support for holothuria leucospilota transplanting and proliferating and commercial application.

The invention discloses fusion protein capable of targeting activation of a RANK signal pathway, a recombinant plasmid and an application thereof. The fusion protein has an amino acid sequence as shown in SEQ ID NO. 1, and is obtained by substituting a segment of a gyrase B sequence for a C terminal of a mouse RANK; the nucleotide sequence coding the fusion protein is shown in SEQ ID NO. 2. After the fusion protein is introduced into a cell, continuous stimulation of a micromolecular medicament of coumermycin is accepted, and a RANK-dependent signal pathway is targetedly activated; and thus side effect caused by disease treatment though ligand-activated RANK signal pathway using acceptors is prevented. A recombinant vector contains the nucleotide sequence shown in SEQ ID NO. 2. The recombinant vector has very important value for RANK function research and RANK-caused disease treatment research.

The invention discloses a method adopting 2,4-dinitrochlorobenzene composite acetic acid method to establish an abnormal bile carrier UC syndrome animal model on the basis of a Uygur medicine body fluid theory. Male wistar line rats are used to establish the animal models, and then subjected to four treatments: dry-hot water feeding, dry-hot feed gavage, dry-hot environment, and mild and continuous stimulation; then a 2,4-dinitrochlorobenzene acetone solution is dropwise added on the backs of the rats, then the rates are forbidden from eating, a pipe is inserted into the colons of the rates from the anus, then a 2,4-dinitrchlorobenzene ethanol solution, an acetic acid solution and normal saline are poured in colon to wash the colon, and finally an abnormal bile carrier UC syndrome animal model is established. The shortage of no related animal model for the research on abnormal bile carrier UC syndrome mechanism and related drug development is overcome, moreover, the modeling method is simple, the modeling rate is high, modeling period is short, the cost is low, the repeatability is good, and the application value is wide.