43 results about "Continuous stimulation" patented technology

Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses of 30 seconds to 5 minutes of continuous stimulation. The treatment paradigm further comprises one or more daily treatment sessions that each include one or more doses for prophylactic or acute treatment of the patient's condition. Vagus nerve stimulation is used to modulate the release of inhibitory neurotransmitters in the brain, such as GABA, norepinephrine, and / or serotonin.

The invention relates to a transcranial magnetic field stimulator with a plurality of stimulating coils which comprises a high voltage charging power supply, a current-limiting resistance, an energy dumped capacitor, a reverse current reflowing diode, a thyristor switch, stimulating coils and a microcomputer controller. The stimulator is characterized in that: a stimulating unit comprises a thyristor switch, a stimulating coil and an energy dumped capacitor; N parallel connected stimulating units are connected to the current-limiting resistance and the high voltage charging power supply end; N stimulating units shared use an energy dumped capacitor; the microcomputer controller ends are respectively connected with the triggering ends of the thyristor switch in every stimulating unit; N is more than or equal to 2. A magnetic field stimulator of the invention can substitute a plurality of magnetic field stimulators in using, realizes the in-turn stimulation of a plurality of stimulating coils, and ensures a plurality of parts to get continuous stimulation from the program control. If the number of the energy dumped capacitor is increased, a plurality of coils not only can be stimulated in time sharing, but also achieving synchronous stimulation and couple stimulation.

The invention discloses a method for in-vitro amplification of NK cells and the NK cells obtained by the same. The method comprises the following steps: taking peripheral blood mononuclear cells (PBMC) separated out from peripheral blood as seed cells, adding the cells into a culture bottle pre-coated with CD16Mab when induced culture begins and enlarged culture is carried out every time, performing continuous stimulation on the cells, and finally obtaining a large amount of high-purity NK cells. Under the situation that the stimulation is performed without using trophoblast cells, the large amount of high-purity NK cells is finally obtained through the method of performing continuous stimulation by coating the culture bottle with CD16Mab, and the use amount of cell factors is reduced.

In a STED fluorescence light microscope pulses of excitation light (3) are applied to a sample, which excite fluorescent entities contained in the sample for fluorescence, and which are focused on at least one focal area. Further, de-excitation light (12) is applied to the sample, which de-excites the excited fluorescent entities and which comprises an intensity zero point in the at least one focal area, as a continuous wave. Fluorescence light emitted by the excited fluorescent entities in the sample is registered after each pulse of the excitation light (3) and overlapping with applying the de-excitation light (13) with high temporal resolution between consecutive pulses of the excitation light (3).

The invention establishes a method for in-vitro amplification of a CD8+T cell and a cell subset of the CD8+T cell. By adding a TLR1 / 2 agonist, a TLR2 / 6 agonist and a TLR5 agonist into an in-vitro culture system for conventionally culturing and amplifying the CD8+T cell or conjunctively utilizing the agonists, the amplification efficiency of the CD8+T cell can be remarkably improved; besides, by utilizing a TLC agonist, the functional CD8+T cell subsets which are difficult to amplify under a conventional culture condition are amplified, such as PD-1+CD8+T cells and TEM CD8+T cells; and the CD8+T cells and the functional cell subsets can be rapidly and largely propagated under the common and continuous stimulation of a TLRs agonist, recombinant cell factors IL-2, IL-7 and IL-15, an anti-human CD3 antibody and anti-human CD28 antibody coated magnetic beads.

The invention discloses a lucidity maintaining device. The lucidity maintaining device is a head-mounted device and consists of a sensing controller and a head-mounted carrier which is sleeved at the head, wherein the sensing controller and the head-mounted carrier are mechanically fixed and electrically connected into a whole; the sensing controller comprises a micro-electromechanical system (MEMS) gyroscope, a control module and a power supply module; the head-mounted carrier comprises a vibration module and a wearable carrier for bearing the vibration module; the MEMS gyroscope performs real-time data acquisition and data processing on triaxial angular velocity signals; the control module is used for calculating and identifying the class of the head action of a person and executing instruction operation corresponding to the head action; the vibration module is used for providing consciousness vibration stimulation to the person. The lucidity maintaining device can realize consciousness vibration stimulation conveniently and timely, can select vibration modes and adjust vibration strength and frequency, achieves an obvious and continuous stimulation effect, is favorable for maintaining excellent lucidity of the person, and has wide application occasions.

The invention relates to the technical field of mouse traps and discloses a continuous mouse trapping device. The continuous mouse trapping device comprises a mouse trapping barrel; a vibration plate is arranged in the mouse trapping barrel, an output shaft connected with a motor of a cam is arranged at the bottom end of the vibration plate, a bait is arranged at the top end of the vibration plate, an infrared inductor is arranged at the bait, a hole is formed in the side wall of the mouse trapping barrel, a mouse storage box is connected to the hole via a pipeline, and a one-way door capable of being opened towards the inside of the mouse storage box only is arranged at one end of the mouse storage box on the pipeline. The continuous mouse trapping device disclosed by the invention is simple in structure and easy to implement, and makes full use of the characteristic that a mouse goes into the hole in a frightened state when seeing the hole, so that the mouse is subjected to strong continuous stimulation from vibration, sound alarm and flash light irradiation after triggering the inductor, and goes into the mouse storage box via the pipeline to be caught; after the stop of an alarm and the vibration motor, the continuous mouse catching device disclosed by the invention is in a standby state and waits for a next mouse to enter the mouse trapping barrel and triggering the inductor, thereby realizing effective continuous trapping.

A device for sexual stimulation, intended for enhancing arousal, facilitating orgasm and improving blood circulation in the genitals to correct sexual inadequacy, comprises two elongated members mutually connected with their first ends. At least one of the members is made of a resilient material such as silicon rubber so that its second end is bent off the second member and adapted to be resiliently brought toward the second member second end to form a dildo. The second end of the first member can be fixedly attached to the second member when brought toward it. At least one vibrating device can be placed in one of the members. The device provides for vaginal extension without extension of a vaginal opening, increases a zone of stimulation, is suitable for frictions in the vagina and makes it possible to achieve intense and continuous stimulation of internal genitals when performing frictional stimulation.

The invention relates to devices for private use which enhance arousal and facilitate orgasm, and can be used for massaging the genital organs and correcting sexual inadequacy. The object of the invention is to enhance sexual sensations, maintain and sustain arousal, facilitate orgasm, and improve blood circulation in the genital organs. The essence of the invention is a device with flexible and elastic elements, which increase a zone of stimulation due to their elasticity and allow the device to be shaped and sized to be suitable for frictions in the vagina due to its flexibility. The claimed invention makes it possible to achieve intense and continuous stimulation of external or internal genital organs when performing frictional vaginal stimulation.

In a STED fluorescence light microscope pulses of excitation light (3) are applied to a sample, which excite fluorescent entities contained in the sample for fluorescence, and which are focused on at least one focal area. Further, de-excitation light (12) is applied to the sample, which de-excites the excited fluorescent entities and which comprises an intensity zero point in the at least one focal area, as a continuous wave. Fluorescence light emitted by the excited fluorescent entities in the sample is registered after each pulse of the excitation light (3) and overlapping with applying the de-excitation light (13) with high temporal resolution between consecutive pulses of the excitation light (3).

The invention discloses a method for improving the spawning efficiency of holothuria leucospilota through continuous stimulation. By means of the operation of the steps of parent holothurian treatment, drying in the shade and parturition hastening, male and female parent holothurian separation, continuous stimulation and the like, the spawning efficiency of tropical female holothuria leucospilotais improved, sufficient holothuria leucospilota fertilized ova are obtained, and large-scale cultivation of tropical holothuria leucospilota fry is possible. The method is easy to operate, low in requirement on equipment and suitable for popularization, and provides technical support for holothuria leucospilota transplanting and proliferating and commercial application.

The invention proposes a system and a method for controlling the process of prescription and administration of direct current stimulation treatments in humans. In the proposed system, the stimulation parameters are all set by a specialist whose credentials are verified through a specific control device different from the device that delivers electrical stimulation. The stimulating device can deliver the stimulation only if the credentials of the specialized subject making the prescription are verified and if the prescription is made according to safety criteria. The system is composed by at least one device for the administration of electrical current connected to two electrodes applied over the skin and by a control device. The control device is connected to one or more devices for the administration of the direct current through a communication channel. The specialist gives his own credentials and is authorized at making the prescription and, accordingly, programming the stimulating device. The prescription defines the stimulus intensity, waveform, polarity, duration, the minimum interval between two consecutive stimulations and the maximum number of stimulations allowed. The stimulating device delivers the stimulation only if the credentials of the specialist are verified and only according to the prescription.

The invention relates to the technical field of medical instruments, in particular to a bladder pressure probe. The bladder pressure probe of the invention consists of a balloon and a pressure sensor, wherein the balloon consists of a body and an inflatable head, the inflatable head is internally provided with an inflatable pipeline and a valve; the pressure sensor can constantly measure the pressure of the bladder and send a pressure signal out of body in real time; a pressure sensing surface of the pressure sensor is positioned outside the balloon and the other part of the pressure sensor is positioned inside the balloon; the bladder pressure probe before inflation can be implanted into the bladder through urethra, the inflated bladder pressure probe cannot be discharged out of body along with urine owing to the swelling of the balloon and floats at the upper layer of the urine in the bladder, thereby avoiding that the probe applies continuous stimulation to trigone of the bladder and blocks off the inner opening of urethra during urination. The bladder pressure probe is simple in structure and convenient for use, can constantly and accurately monitor the pressure of the bladder in real time for a long time, and is suitable for urodynamic examination and patients with a loss of urination desire.

The invention relates to the technical field of medical instruments, in particular to acupuncture point pressing therapeutic equipment. The acupuncture point pressing therapeutic equipment comprises two moment arms, a pressure clamp and a plurality of sets of acupuncture point pressing mechanisms, wherein the acupuncture point pressing mechanisms are arranged on the two moment arms respectively, and a clamp body with a small upper opening and a large lower opening is formed by the two moment arms; the pressure clamp is fixedly arranged between the tops of the two moment arms; each acupuncture point pressing mechanism is composed of a long guide rail of an annular structure and a pressing rod installed on the guide rail, each pressing rod penetrates through the corresponding guide rail and is locked through two fastening nuts, and an acupuncture point pressing head is arranged at the inner end of each pressing rod. According to the acupuncture point pressing therapeutic equipment, continuous pressure transmitted by elastic force of the pressure clamp serves as acupuncture point stimulation, deep acupuncture points on portions such as the head can be stimulated, the stimulation of the deep acupuncture points is achieved, and continuous stimulation can be achieved; meanwhile, multiple ashi acupuncture points can be found fast, and the good curative effect is achieved.

Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses of 30 seconds to 5 minutes of continuous stimulation. The treatment paradigm further comprises one or more daily treatment sessions that each include one or more doses for prophylactic or acute treatment of the patient's condition. Vagus nerve stimulation is used to modulate the release of inhibitory neurotransmitters in the brain, such as GABA, norepinephrine, and / or serotonin.

The invention relates to the technical field of mouse traps and discloses a continuous mouse trapping device. The continuous mouse trapping device comprises a mouse trapping barrel; a vibration plate is arranged in the mouse trapping barrel, an output shaft connected with a motor of a cam is arranged at the bottom end of the vibration plate, a bait is arranged at the top end of the vibration plate, an infrared inductor is arranged at the bait, a hole is formed in the side wall of the mouse trapping barrel, a mouse storage box is connected to the hole via a pipeline, and a one-way door capable of being opened towards the inside of the mouse storage box only is arranged at one end of the mouse storage box on the pipeline. The continuous mouse trapping device disclosed by the invention is simple in structure and easy to implement, and makes full use of the characteristic that a mouse goes into the hole in a frightened state when seeing the hole, so that the mouse is subjected to strong continuous stimulation from vibration, sound alarm and flash light irradiation after triggering the inductor, and goes into the mouse storage box via the pipeline to be caught; after the stop of an alarm and the vibration motor, the continuous mouse catching device disclosed by the invention is in a standby state and waits for a next mouse to enter the mouse trapping barrel and triggering the inductor, thereby realizing effective continuous trapping.

The invention provides a collateral dredging instrument parameter optimization method based on subjective and objective data fusion, and relates to the technical field of collateral dredging instruments, and the method comprises the following steps: generating an initial electrical stimulation parameter according to an initial electrophysiological signal of the collateral dredging instrument for detecting a target acupoint, and starting the output; in an initial stage of starting output, receiving a subjective trigger signal which is fed back by a user and represents a tolerable critical point, and recording a stimulation intensity value corresponding to the subjective trigger signal as a current personal comfort threshold value of the user; performing continuous stimulation by taking the current personal comfort threshold as basic intensity, and simultaneously executing the following parallel steps: acquiring a continuous or discrete real-time subjective comfort feedback signal input by a user through an interactive interface in real time; monitoring a dynamic electrophysiological signal of the target acupuncture point in real time, and analyzing the change trend of the dynamic electrophysiological signal to generate an objective adjustment suggestion signal; and performing fusion analysis on the real-time subjective comfort feedback signal and the objective adjustment suggestion signal, and performing real-time dynamic adjustment on the current electrical stimulation parameter according to the fusion analysis.

The invention provides a brain electrical stimulation control method and device, a medium and computer equipment, and the method comprises the steps: setting an electrical stimulation period time signal through a local control module, and dividing the electrical stimulation period time signal into a stimulation stage, a window stage and a recovery stage with continuous time periods; in the stimulation stage, an electrical stimulation signal with preset parameters is output through the time-multiplexed electrode slice; in the empty window stage, disconnection or hardware protection is carried out on the electrode slices to shield crosstalk of stimulation signals to an electroencephalogram acquisition channel; in the recovery stage, electroencephalogram signals are collected and subjected to suppression algorithm processing to eliminate residual artifacts, and in the recovery stage, the collected electroencephalogram signals are subjected to suppression algorithm processing to eliminate residual low-frequency artifacts of electrode capacitance. The problems of hardware redundancy and artifact interference of an existing electrical stimulation system are effectively solved, and accuracy and safety are improved.

The invention discloses an acupuncture apparatus for acupuncture. The acupuncture apparatus comprises a puncture needle and a hollow thin tube soft needle, wherein the puncture needle is metal needle tubing; the head end of the puncture needle is a needle tip with a cutting edge; the tail end of the puncture needle is a needle handle fixed to and communicated with a needle body; the head end of the hollow thin tube soft needle is conical; the tail end of the hollow thin tube soft needle adopts a horn-mouth-shaped expansion structure; the diameter of the horn mouth of the hollow thin tube soft needle is larger than that of the needle tubing of the hollow thin tube soft needle; when the needle body of the puncture needle is wholly inserted into the hollow thin tube soft needle, the head end of the hollow thin tube soft needle does not exceed the inclined plane of the needle tip of the puncture needle. According to the acupuncture apparatus for acupuncture, longer-time needle retaining is realized, continuous stimulation of acupuncture points and main and collateral channels, and adjustment of Ying-Wei, and qi and blood of bodies can be realized, and thus a better acupuncture treatment effect is achieved.

The invention relates to medicine, and more particularly to a novel method for the control of stepping movements in patients with traumatic injuries or diseases of the spinal cord and / or the brain using transcutaneous electrical stimulation, which includes continuously stimulating the spinal cord at the level of the C5-C6, T11-T12 and L1-L2 vertebrae and simultaneously creating a synergistic effect to control foot movement by means of spatial-temporal stimulation of the flexor and extensor muscles of the lower leg in the corresponding phases of the gait cycle. This combined spinal and muscular stimulation enables a coordinated, complete gait, in which the patient is able to control the stepping movements, including controlling foot movements.

Wearable devices, including topical patches or sleeves applied to the skin, are used to stimulate and recognize changes in blood flow and clotting. A noninvasive transcutaneous electrical muscle stimulator (EMS) is embedded in the patch or sleeve and delivers continuous stimulation to perivascular tissue to promote blood flow. The stimulation system includes a series of electrodes positioned on the skin via the patch or sleeve and an external programmable generator with wireless connectivity during stimulation. Biosensors in the patch or sleeve and other biosensors applied to the body periodically check for abnormal biomarker patterns. These patterns may be used by artificial intelligence (AI) / machine learning (ML) systems as early indicators or by predictive methods to predict changes in blood flow and clotting, such as those caused by venous thrombosis. When abnormal biomarker patterns are detected, an alert may be sent and a therapeutic response may be initiated.

The invention provides a continuous-stimulation tissue occlusion gun which can be used in cooperation with a nail bin containing a plurality of closing nails. The continuous-stimulation tissue occlusion gun is characterized by comprising an inner rod, a sleeve and a stimulation unit, wherein the inner rod is sleeved with the sleeve, the sleeve and the inner rod can relatively slide, and the stimulation unit is arranged between the inner rod and the sleeve and can slide along with the sleeve. The upper section of the inner rod is segmented into a left forceps foot and a right forceps foot. The two forceps feet can extend out of the sleeve to be opened. The sleeve slides forwards so that the two forceps feet can be closed again. The inner side faces of the front ends of the two forceps feet are provided with nail grooves with opposite openings. The nail grooves can be detachably clamped to the nail bin. The stimulation unit is provided with two stimulation blocks and stimulation handles, wherein the stimulation blocks are located on the inner side face of the front end of the sleeve and arranged oppositely, and the stimulation handles are connected to the bottoms of the stimulation blocks respectively and exposed out of the outer wall of the lower end of the sleeve. The stimulation blocks correspond to the nail grooves and can stimulate a single closing nail in sequence. The stimulation handles are used for controlling the stimulation blocks. The continuous-stimulation tissue occlusion gun can reduce wounds, is easy to operate and can be continuously used.

The invention belongs to the field of computer digital video image processing, and discloses a method and system for subjective evaluation of video image quality. The evaluation method includes: determining evaluators, scoring standards and viewing conditions, selecting test sequences that meet the requirements; for the selected test sequence group, using the evaluation system to test; saving test results, and performing data statistics and analysis. The evaluation system realizes the recording of evaluator information, data statistics and analysis of evaluation results, and controls the entire evaluation process, including: a user management module, a material management module, a sequence playback module, and a data management module. The invention effectively combines three evaluation modes of multi-stimulus evaluation mode, double-stimulus-like continuous quality evaluation mode and dual-screen display to subjectively evaluate video image quality, and expands the scope of application of the subjective evaluation method. When evaluating qualitatively indistinguishable sequences, the present invention improves the stability and reliability of the evaluation results.

The invention discloses a lucidity maintaining device. The lucidity maintaining device is a head-mounted device and consists of a sensing controller and a head-mounted carrier which is sleeved at the head, wherein the sensing controller and the head-mounted carrier are mechanically fixed and electrically connected into a whole; the sensing controller comprises a micro-electromechanical system (MEMS) gyroscope, a control module and a power supply module; the head-mounted carrier comprises a vibration module and a wearable carrier for bearing the vibration module; the MEMS gyroscope performs real-time data acquisition and data processing on triaxial angular velocity signals; the control module is used for calculating and identifying the class of the head action of a person and executing instruction operation corresponding to the head action; the vibration module is used for providing consciousness vibration stimulation to the person. The lucidity maintaining device can realize consciousness vibration stimulation conveniently and timely, can select vibration modes and adjust vibration strength and frequency, achieves an obvious and continuous stimulation effect, is favorable for maintaining excellent lucidity of the person, and has wide application occasions.

The present invention discloses a rapid neural response telemetry (NRT) circuit and system of a cochlear implant. The circuit comprises a stimulus generator, a signal amplifier, an analog-to-digital (A / D) converter and a calculated data memory. The stimulus generator zero charges in a nerve tissue before stimulus onset and offset, and the onset asynchrony of two continuous stimuli on the same electrode may be adjusted at will. The signal amplifier filters and amplifies nervous impulse signals that are evoked by electric stimuli and received by a collector electrode. The A / D converter can adjust the sampling frequency and start-up time, and is connected to the signal amplifier to perform A / D conversion on amplified analog signals. The calculated data memory is connected to the A / D converter to calculate and store the data undergoing A / D conversion. According to the present invention, a stimulus circuit is improved to reduce artifacts of NRT so that key parameters for NRT can be flexibly controlled, the success rate in eliciting NRT is improved, and the NRT speed is greatly improved by calculating and storing the data.

The invention discloses a palm electrical stimulation control system based on elbow motion driving. An inertia measurement module is used for acquiring an attitude quaternion of an elbow, a bending sensor module is used for acquiring a finger bending angle, a data processing module is used for summarizing the attitude quaternion and the finger bending angle and sending the summarized data to an upper computer, the upper computer sets electric simulation control parameters by periodically utilizing the received attitude quaternion and the received finger bending angle according to a preset control period, and then sends a control instruction to electrical stimulation equipment, and the electrical stimulation equipment outputs corresponding pulses to stimulate muscles corresponding to fingers to contract according to the control instruction sent by the upper computer. The palm electrical stimulation control system disclosed by the invention can automatically adjust the pulse control parameters of the electrical stimulation equipment and realize the automatic continuous stimulation of the muscles corresponding to the fingers.

The present invention relates to restoration of motor activity for dysfunctions of gait. A method is provided using electrical stimulation of the spinal cord, including simultaneous continuous stimulation of the spinal cord at least at the level of T11-T12 vertebrae and spatio-temporal and spatio-selective stimulation of the spinal cord roots at the level of T11 and L1 vertebrae. A neuroprosthesis system is provided, including a multi-channel stimulator for transcutaneous electrical stimulation of the spinal cord that includes at least one storage device and one or more programs that are loaded into at least one storage device, with one or more programs containing instructions, an electrode or electrode array connected to the stimulator, at least one recording device to detect the contact and / or detachment of a lower limb and / or a walking aid on which the upper limb leans during locomotion, and a device for triggering or cessation of stimulation.

The invention relates to an intraoperative nerve continuous stimulation device, comprising: a clamp main body, the clamp main body comprising a clamping arm capable of being opened and closed, the clamping arm being used for clamping a tested nerve; the clamping part of the clamping arm is provided with an electrode slice which can be attached to a tested nerve, an electrical connection assembly is arranged in the clamping arm, the clamping arm is connected with a cable, the electrical connection assembly is electrically connected between the electrode slice and the cable, and the cable is externally connected with a stimulation current generating device; and the clamping device further comprises penetrating through holes which are formed in the clamping arms and are used for the suture lines to pass through. According to the device, a doctor can be assisted in taking and placing the nerve electrical stimulation electrode in an operation, the nerve electrical stimulation electrode can be sutured and fixed on other tissues near a nerve, and nerve continuous stimulation monitoring can be stably and continuously performed in the operation.

The invention discloses fusion protein capable of targeting activation of a RANK signal pathway, a recombinant plasmid and an application thereof. The fusion protein has an amino acid sequence as shown in SEQ ID NO. 1, and is obtained by substituting a segment of a gyrase B sequence for a C terminal of a mouse RANK; the nucleotide sequence coding the fusion protein is shown in SEQ ID NO. 2. After the fusion protein is introduced into a cell, continuous stimulation of a micromolecular medicament of coumermycin is accepted, and a RANK-dependent signal pathway is targetedly activated; and thus side effect caused by disease treatment though ligand-activated RANK signal pathway using acceptors is prevented. A recombinant vector contains the nucleotide sequence shown in SEQ ID NO. 2. The recombinant vector has very important value for RANK function research and RANK-caused disease treatment research.

An apparatus for treatment of a patient using multichannel desynchronizing stimulation includes: (1) n stimulation contacts, with n being 2 or greater; (2) a signal generator connected to the n stimulation contacts; and (3) a controller connected to the signal generator to direct operation of the signal generator, wherein the controller is configured to direct the signal generator to apply a sequence of stimuli through the n stimulation contacts, such that inter-stimulation times in the sequence are time-varying, and successive stimuli in the sequence are non-overlapping in time.