32 results about "Continuous stimulation" patented technology

In a STED fluorescence light microscope pulses of excitation light (3) are applied to a sample, which excite fluorescent entities contained in the sample for fluorescence, and which are focused on at least one focal area. Further, de-excitation light (12) is applied to the sample, which de-excites the excited fluorescent entities and which comprises an intensity zero point in the at least one focal area, as a continuous wave. Fluorescence light emitted by the excited fluorescent entities in the sample is registered after each pulse of the excitation light (3) and overlapping with applying the de-excitation light (13) with high temporal resolution between consecutive pulses of the excitation light (3).

The invention establishes a method for in-vitro amplification of a CD8+T cell and a cell subset of the CD8+T cell. By adding a TLR1 / 2 agonist, a TLR2 / 6 agonist and a TLR5 agonist into an in-vitro culture system for conventionally culturing and amplifying the CD8+T cell or conjunctively utilizing the agonists, the amplification efficiency of the CD8+T cell can be remarkably improved; besides, by utilizing a TLC agonist, the functional CD8+T cell subsets which are difficult to amplify under a conventional culture condition are amplified, such as PD-1+CD8+T cells and TEM CD8+T cells; and the CD8+T cells and the functional cell subsets can be rapidly and largely propagated under the common and continuous stimulation of a TLRs agonist, recombinant cell factors IL-2, IL-7 and IL-15, an anti-human CD3 antibody and anti-human CD28 antibody coated magnetic beads.

A device for sexual stimulation, intended for enhancing arousal, facilitating orgasm and improving blood circulation in the genitals to correct sexual inadequacy, comprises two elongated members mutually connected with their first ends. At least one of the members is made of a resilient material such as silicon rubber so that its second end is bent off the second member and adapted to be resiliently brought toward the second member second end to form a dildo. The second end of the first member can be fixedly attached to the second member when brought toward it. At least one vibrating device can be placed in one of the members. The device provides for vaginal extension without extension of a vaginal opening, increases a zone of stimulation, is suitable for frictions in the vagina and makes it possible to achieve intense and continuous stimulation of internal genitals when performing frictional stimulation.

In a STED fluorescence light microscope pulses of excitation light (3) are applied to a sample, which excite fluorescent entities contained in the sample for fluorescence, and which are focused on at least one focal area. Further, de-excitation light (12) is applied to the sample, which de-excites the excited fluorescent entities and which comprises an intensity zero point in the at least one focal area, as a continuous wave. Fluorescence light emitted by the excited fluorescent entities in the sample is registered after each pulse of the excitation light (3) and overlapping with applying the de-excitation light (13) with high temporal resolution between consecutive pulses of the excitation light (3).

Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses of 30 seconds to 5 minutes of continuous stimulation. The treatment paradigm further comprises one or more daily treatment sessions that each include one or more doses for prophylactic or acute treatment of the patient's condition. Vagus nerve stimulation is used to modulate the release of inhibitory neurotransmitters in the brain, such as GABA, norepinephrine, and / or serotonin.

The invention relates to the technical field of mouse traps and discloses a continuous mouse trapping device. The continuous mouse trapping device comprises a mouse trapping barrel; a vibration plate is arranged in the mouse trapping barrel, an output shaft connected with a motor of a cam is arranged at the bottom end of the vibration plate, a bait is arranged at the top end of the vibration plate, an infrared inductor is arranged at the bait, a hole is formed in the side wall of the mouse trapping barrel, a mouse storage box is connected to the hole via a pipeline, and a one-way door capable of being opened towards the inside of the mouse storage box only is arranged at one end of the mouse storage box on the pipeline. The continuous mouse trapping device disclosed by the invention is simple in structure and easy to implement, and makes full use of the characteristic that a mouse goes into the hole in a frightened state when seeing the hole, so that the mouse is subjected to strong continuous stimulation from vibration, sound alarm and flash light irradiation after triggering the inductor, and goes into the mouse storage box via the pipeline to be caught; after the stop of an alarm and the vibration motor, the continuous mouse catching device disclosed by the invention is in a standby state and waits for a next mouse to enter the mouse trapping barrel and triggering the inductor, thereby realizing effective continuous trapping.

The invention provides a continuous-stimulation tissue occlusion gun which can be used in cooperation with a nail bin containing a plurality of closing nails. The continuous-stimulation tissue occlusion gun is characterized by comprising an inner rod, a sleeve and a stimulation unit, wherein the inner rod is sleeved with the sleeve, the sleeve and the inner rod can relatively slide, and the stimulation unit is arranged between the inner rod and the sleeve and can slide along with the sleeve. The upper section of the inner rod is segmented into a left forceps foot and a right forceps foot. The two forceps feet can extend out of the sleeve to be opened. The sleeve slides forwards so that the two forceps feet can be closed again. The inner side faces of the front ends of the two forceps feet are provided with nail grooves with opposite openings. The nail grooves can be detachably clamped to the nail bin. The stimulation unit is provided with two stimulation blocks and stimulation handles, wherein the stimulation blocks are located on the inner side face of the front end of the sleeve and arranged oppositely, and the stimulation handles are connected to the bottoms of the stimulation blocks respectively and exposed out of the outer wall of the lower end of the sleeve. The stimulation blocks correspond to the nail grooves and can stimulate a single closing nail in sequence. The stimulation handles are used for controlling the stimulation blocks. The continuous-stimulation tissue occlusion gun can reduce wounds, is easy to operate and can be continuously used.

The invention discloses a lucidity maintaining device. The lucidity maintaining device is a head-mounted device and consists of a sensing controller and a head-mounted carrier which is sleeved at the head, wherein the sensing controller and the head-mounted carrier are mechanically fixed and electrically connected into a whole; the sensing controller comprises a micro-electromechanical system (MEMS) gyroscope, a control module and a power supply module; the head-mounted carrier comprises a vibration module and a wearable carrier for bearing the vibration module; the MEMS gyroscope performs real-time data acquisition and data processing on triaxial angular velocity signals; the control module is used for calculating and identifying the class of the head action of a person and executing instruction operation corresponding to the head action; the vibration module is used for providing consciousness vibration stimulation to the person. The lucidity maintaining device can realize consciousness vibration stimulation conveniently and timely, can select vibration modes and adjust vibration strength and frequency, achieves an obvious and continuous stimulation effect, is favorable for maintaining excellent lucidity of the person, and has wide application occasions.

The present invention discloses a rapid neural response telemetry (NRT) circuit and system of a cochlear implant. The circuit comprises a stimulus generator, a signal amplifier, an analog-to-digital (A / D) converter and a calculated data memory. The stimulus generator zero charges in a nerve tissue before stimulus onset and offset, and the onset asynchrony of two continuous stimuli on the same electrode may be adjusted at will. The signal amplifier filters and amplifies nervous impulse signals that are evoked by electric stimuli and received by a collector electrode. The A / D converter can adjust the sampling frequency and start-up time, and is connected to the signal amplifier to perform A / D conversion on amplified analog signals. The calculated data memory is connected to the A / D converter to calculate and store the data undergoing A / D conversion. According to the present invention, a stimulus circuit is improved to reduce artifacts of NRT so that key parameters for NRT can be flexibly controlled, the success rate in eliciting NRT is improved, and the NRT speed is greatly improved by calculating and storing the data.

The invention discloses a palm electrical stimulation control system based on elbow motion driving. An inertia measurement module is used for acquiring an attitude quaternion of an elbow, a bending sensor module is used for acquiring a finger bending angle, a data processing module is used for summarizing the attitude quaternion and the finger bending angle and sending the summarized data to an upper computer, the upper computer sets electric simulation control parameters by periodically utilizing the received attitude quaternion and the received finger bending angle according to a preset control period, and then sends a control instruction to electrical stimulation equipment, and the electrical stimulation equipment outputs corresponding pulses to stimulate muscles corresponding to fingers to contract according to the control instruction sent by the upper computer. The palm electrical stimulation control system disclosed by the invention can automatically adjust the pulse control parameters of the electrical stimulation equipment and realize the automatic continuous stimulation of the muscles corresponding to the fingers.

The present invention relates to restoration of motor activity for dysfunctions of gait. A method is provided using electrical stimulation of the spinal cord, including simultaneous continuous stimulation of the spinal cord at least at the level of T11-T12 vertebrae and spatio-temporal and spatio-selective stimulation of the spinal cord roots at the level of T11 and L1 vertebrae. A neuroprosthesis system is provided, including a multi-channel stimulator for transcutaneous electrical stimulation of the spinal cord that includes at least one storage device and one or more programs that are loaded into at least one storage device, with one or more programs containing instructions, an electrode or electrode array connected to the stimulator, at least one recording device to detect the contact and / or detachment of a lower limb and / or a walking aid on which the upper limb leans during locomotion, and a device for triggering or cessation of stimulation.

The invention discloses a method for improving the spawning efficiency of holothuria leucospilota through continuous stimulation. By means of the operation of the steps of parent holothurian treatment, drying in the shade and parturition hastening, male and female parent holothurian separation, continuous stimulation and the like, the spawning efficiency of tropical female holothuria leucospilotais improved, sufficient holothuria leucospilota fertilized ova are obtained, and large-scale cultivation of tropical holothuria leucospilota fry is possible. The method is easy to operate, low in requirement on equipment and suitable for popularization, and provides technical support for holothuria leucospilota transplanting and proliferating and commercial application.

The invention discloses fusion protein capable of targeting activation of a RANK signal pathway, a recombinant plasmid and an application thereof. The fusion protein has an amino acid sequence as shown in SEQ ID NO. 1, and is obtained by substituting a segment of a gyrase B sequence for a C terminal of a mouse RANK; the nucleotide sequence coding the fusion protein is shown in SEQ ID NO. 2. After the fusion protein is introduced into a cell, continuous stimulation of a micromolecular medicament of coumermycin is accepted, and a RANK-dependent signal pathway is targetedly activated; and thus side effect caused by disease treatment though ligand-activated RANK signal pathway using acceptors is prevented. A recombinant vector contains the nucleotide sequence shown in SEQ ID NO. 2. The recombinant vector has very important value for RANK function research and RANK-caused disease treatment research.

The invention discloses a method adopting 2,4-dinitrochlorobenzene composite acetic acid method to establish an abnormal bile carrier UC syndrome animal model on the basis of a Uygur medicine body fluid theory. Male wistar line rats are used to establish the animal models, and then subjected to four treatments: dry-hot water feeding, dry-hot feed gavage, dry-hot environment, and mild and continuous stimulation; then a 2,4-dinitrochlorobenzene acetone solution is dropwise added on the backs of the rats, then the rates are forbidden from eating, a pipe is inserted into the colons of the rates from the anus, then a 2,4-dinitrchlorobenzene ethanol solution, an acetic acid solution and normal saline are poured in colon to wash the colon, and finally an abnormal bile carrier UC syndrome animal model is established. The shortage of no related animal model for the research on abnormal bile carrier UC syndrome mechanism and related drug development is overcome, moreover, the modeling method is simple, the modeling rate is high, modeling period is short, the cost is low, the repeatability is good, and the application value is wide.

The invention provides a breast augmentation massage device and relates to the technical field of breast augmentation equipment. The defect that an existing breast augmentation product easily causes sequela is overcome. The massage device comprises a battery charging host, a left host, a right host and a remote controller, wherein the battery charging host is electrically connected with the left host and the right host which generate vibration and low-frequency signals, wireless connection control is achieved through the remote controller, and the battery charging host is internally provided with a ZigBee wireless communication part. The massage device stimulates a breast part through vibration and EMS (enhanced message service) signals, the metabolism of the breast is promoted through the continuous stimulation on the breast, and the breast is effectively augmented and maintained.