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Method and system for regulation and restoration of independent stepping for patients with motor pathology

A patient, exercise technique with applications in neurophysiology and rehabilitation

Pending Publication Date: 2022-02-18
COSYMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the transmission of commands to initiate and control stepping from the brain to the motor pools of the hind limbs needs to bypass the spinal cord injury that separates these sites, which is not addressed by the stimulation described above

Method used

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  • Method and system for regulation and restoration of independent stepping for patients with motor pathology
  • Method and system for regulation and restoration of independent stepping for patients with motor pathology
  • Method and system for regulation and restoration of independent stepping for patients with motor pathology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0137] Example 1. Voluntary arm movement increases the response to involuntary leg movement induced by transcutaneous electrical stimulation of the spinal cord magnitude.

[0138] This study was performed to demonstrate that rhythmic arm movement facilitates the locomotor effects induced by TESSC.

[0139] method

[0140] The study was carried out in Velikie Luki State Academy of Physical Education and Sports (VLSAPEC). Healthy volunteers - young men, employees and students of VLSAPEC (N=11, 20-35 years old) participated in the study. Informed written consent to participate in the trial was obtained according to the principles of the Declaration of Helsinki.

[0141] refer to figure 1 , subjects in a biomechanical training machine for neurorehabilitation of motor and visceral function in a semi-recumbent position ( figure 1). The training machine provides random or forced movement of the legs and / or arms. Leg movements are performed in the hip, knee and ankle joi...

Embodiment 2

[0151] Example 2. Spatiotemporal transcutaneous electrical stimulation of the spinal cord modulates characteristics of human stepping movements.

[0152] This study was performed to demonstrate that it is possible to modulate the swing phase in the stepping cycle (flexion) by periodically stimulating the root of the spinal cord at the level of the T11 vertebra according to the stepping phase and by periodically stimulating the root of the L1 vertebra according to the stepping phase. At the root of the spinal cord at the level, it is possible to regulate the stance phase (extension).

[0153] method

[0154] The study was conducted at Velikie Luki State Academy of Physical Education and Sports (VLSAPEC). Healthy volunteers - young men, employees and students of VLSAPEC (N=9, 20-35 years old) participated in the study. Informed written consent to participate in the trial was obtained according to the principles of the Declaration of Helsinki.

[0155] refer to Figure 5 ...

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Abstract

The present invention relates to restoration of motor activity for dysfunctions of gait. A method is provided using electrical stimulation of the spinal cord, including simultaneous continuous stimulation of the spinal cord at least at the level of T11-T12 vertebrae and spatio-temporal and spatio-selective stimulation of the spinal cord roots at the level of T11 and L1 vertebrae. A neuroprosthesis system is provided, including a multi-channel stimulator for transcutaneous electrical stimulation of the spinal cord that includes at least one storage device and one or more programs that are loaded into at least one storage device, with one or more programs containing instructions, an electrode or electrode array connected to the stimulator, at least one recording device to detect the contact and / or detachment of a lower limb and / or a walking aid on which the upper limb leans during locomotion, and a device for triggering or cessation of stimulation.

Description

technical field [0001] The present disclosure relates to medicine and medical equipment, and more particularly to neurophysiology and rehabilitation. Background technique [0002] Invasive approach to spinal cord stimulation in monkeys with hindlimb paralysis (Marco Capogrosso et al., "A brain-spinal interface that alleviates gait deficits following spinal cord injury in primates", Nature, vol. 539, pp. 284- 288 (2016)) and an invasive approach to the stimulation of the spinal cord of mice with hindlimb paralysis (Parag Gad et al., “Forelimb EMG-based triggers for controlling electronic spinal bridges to enable hindlimb stepping in mice following complete spinal cord injury ", Journal of Neural Engineering and Rehabilitation (2012)) is known. Rhythmic electrical stimulation of the motor pool of the hindlimb flexors and hindlimb extensors is triggered by signals in the cerebral cortex that detect phases of the motor cycle in monkeys with unilateral spinal cord transection (h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/36
CPCA61N1/36014A61N1/36003A61F2/72A61N1/36034A61N1/0456
Inventor Y·P·格拉西门科T·R·莫斯科基纳A·A·格里辛
Owner COSYMA LTD
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