The invention discloses anti-aging anti-wrinkle essence containing tremella fuciformis, hesperidin and soluble protein. The essence is prepared from, by weight, 78.6% to 88.3% of deionized water, 8% to 15% of 1,3-propylene glycol, 1.2% to 2.5% of polyethylene glycol-8, 0.5% to 0.7% of burdock extract, 0.3% to 0.4% of wolfberry extract, 0.2% to 0.3% of ulmus pumila bark extract, 0.05% to 0.1% of fragrant citrus extract, 0.18% to 0.25% of 1,2-hexanediol, 0.15% to 0.25% of p-hydroxyacetophenone, 0.08% to 0.15% of alpha glucosyl hesperidin, 0.7% to 1.2% of soluble protein polysaccharide, 0.05% of3-o-ethyl ascorbic acid, 0.08% to 0.15% of tremella polysaccharide, 0.1% of sodium hyaluronate, 0.04% of polyacrylate cross-linked polymer-6, 0.03% of menthol, 0.04% of PEG-40 castor oil and 0.002% ofrosa damascena flower oil. The anti-aging anti-wrinkle essence contains multiple kinds of natural plant extract, skin aging is delayed, skin is relieved and recovered, various kinds of scytitis caused by hormone are treated, and the plant extract can deeply nourish and recover the skin.